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THE RELATIONSHIP BETWEEN VITAMIN D3 LEVELS AND HYPOTHYROIDISM
THE RELATIONSHIP BETWEEN VITAMIN D3 LEVELS AND HYPOTHYROIDISM
Dilshad Hamad Mustafa a, Ribwar Arsalan Mohammed b, Aveen Muhsin Asaad c, and Dawan Jamal Hawezy d
a College of Medicine, Hawler Medical University, Kurdistan Region, Iraq.
b College of Nursing, University of Raparin, Kurdistan Region, Iraq.
c Koya Technical Institute, Erbil Polytechnic University, Kurdistan Region, Iraq.
d College of Medicine, Koya University, Kurdistan Region, Iraq.
Submitted: 12/9/2021; Accepted: 30/5/2022; Published: 21/6/2022
DOI Link: https://doi.org/10.17656/jsmc.10355
ABSTRACT
Background
It has been well observed that vitamin D deficiency may increase the prevalence of hypothyroidism. However, there is little information on the relationship between vitamin D levels and thyroid diseases amongst the Kurdish population.
Objectives
To find an association between thyroid function parameters and levels of Vit. D among two different groups.
Patients and Methods
A case-control study was employed; two groups participated in the study, the first group was healthy individuals, and the other group was those with hypothyroidism.
Results
The results of 90 persons were collected in the recent study. The mean age was 42.76 ± 9.47. The majority of the participants were women (52.2%). Vitamin D levels were deficient in most participants (50%), which means lower than 20.1 ng/ ml. Only about 37% of the participants had an average level of Vit. D.
Conclusion
Deficiency in Vitamin D3 is significantly associated with all thyroid function parameters.
KEYWORDS
Relationship, Vitamin D3, and Hypothyroidism.
References
1. Mazahery H, von Hurst PR. Factors affecting 25-hydroxyvitamin D concentration in response to vitamin D supplementation. Nutrients. 2015;7(7):5111–42.
2. Tiwari P, Sharma N. Role of Vitamin D in Various Illnesses: A Review. J Pharm Care Heal Syst. 2017;04(03).
3. Peterlik M, Cross HS. Vitamin D and calcium deficits predispose to multiple chronic diseases. Eur J Clin Invest [Internet]. 2005 May 1;35(5):290–304. Available from: https://doi.org/10.1111/j.1365-2362.2005.01487.x
4. Nam GE, Kim DH, Cho KH, Park YG, Do Han K, Kim SM, et al. 25-Hydroxyvitamin D insufficiency is associated with cardiometabolic risk in Korean adolescents: the 2008–2009 Korea National Health and Nutrition Examination Survey (KNHANES). Public Health Nutr. 2014;17(1):186–94.
5. Martins JS, Palhares MDO, Teixeira OCM, Gontijo Ramos M. Vitamin D Status and Its Association with Parathyroid Hormone Concentration in Brazilians. J Nutr Metab. 2017;2017.
6. Kelishadi R. Childhood overweight, obesity, and metabolic syndrome in developing countries. Epidemiol Rev. 2007;29(1):62–76.
7. Klecha AJ, Arcos MLB, Frick L, Genaro AM, Cremaschi G. Immune-endocrine interactions in autoimmune thyroid diseases. Neuroimmunomodulation. 2008;15(1):68–75.
8. Hantoosh HA, Mahdi MH, Imran BW, Yahya AA. Prevalence of Vitamin D deficiency in Iraqi females at reproductive age. Med J Babylon. 2019;16(2):119.
9. Al-Alyani H, Al-Turki HA, Al-Essa ON, Alani FM, Sadat-Ali M. Vitamin D deficiency in Saudi Arabians: a reality or simply hype: a meta-analysis (2008–2015). J Family Community Med. 2018;25(1):1.
10. Castellano C-A, Laurin D, Langlois M-F, Fortier M, Tessier D, Gaudreau P, et al. Thyroid function and cognition in the euthyroid elderly: A case-control study embedded in Quebec longitudinal study–NuAge. Psychoneuroendocrinology. 2013;38(9):1772–6.
11. Niafar M, Pourafkari L, Aminmozaffari S, Nader ND. Association of vitamin D deficiency and thyroid function in postmenopausal women. Adv Pharm Bull. 2016;6(4):639.
12. Mackawy AMH, Al-Ayed BM, Al-Rashidi BM. Vitamin D deficiency and its association with thyroid disease. Int J Health Sci (Qassim). 2013;7(3):267.
13. Jyotsna VP, Sahoo A, Singh AK, Sreenivas V, Gupta N. Bone mineral density in patients of Graves disease pre-& post-treatment in a predominantly vitamin D deficient population. Indian J Med Res. 2012;135(1):36.
14. Effraimidis G, Badenhoop K, Tijssen JGP, Wiersinga WM. Vitamin D deficiency is not associated with the early stages of thyroid autoimmunity. Eur J Endocrinol. 2012;167(1):43.
15. Simsek Y, Cakır I, Yetmis M, Dizdar OS, Baspinar O, Gokay F. Effects of Vitamin D treatment on thyroid autoimmunity. J Res Med Sci Off J Isfahan Univ Med Sci. 2016;21.
16. Smith MA, McHenry C, Oslapas R, Hofmann C, Hessel P, Paloyan E. Altered TSH levels associated with increased serum 1, 25-dihydroxy vitamin D3: a possible link between thyroid and parathyroid disease. Surgery. 1989;106(6):987–91.
17. GROSS HA, APPLEMAN JR MD, NICOLOFF JT. Effect of biologically active steroids on thyroid function in man. J Clin Endocrinol Metab. 1971;33(2):242–8.
18. Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D is essential in estrogen biosynthesis of both female and male gonads. Endocrinology. 2000;141(4):1317–24.
19. Barchetta I, Baroni MG, Leonetti F, De Bernardinis M, Bertoccini L, Fontana M, et al. TSH levels are associated with vitamin D status and seasonality in an adult population of euthyroid adults. Clin Exp Med. 2015;15(3):389–96.
20. Wang J, Lv S, Chen G, Gao C, He J, Zhong H, et al. Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Nutrients. 2015;7(4):2485–98.
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