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ROLE OF FECAL CALPROTECTIN IN DIFFERENTIATION OF INFLAMMATORY BOWEL DISEASES IN PATIENTS COMPLAINING OF ABDOMINAL SYMPTOMS AND REFERRED FOR COLONOSCOPY
ROLE OF FECAL CALPROTECTIN IN DIFFERENTIATION OF INFLAMMATORY BOWEL DISEASES IN PATIENTS COMPLAINING OF ABDOMINAL SYMPTOMS AND REFERRED FOR COLONOSCOPY
Trifa A. Mahmood a,b, Mohammed O. Mohammed a,b, Dana T. Gharib b, Taha A. Mohamad a,b, Muhsin A. Mohammed b, and Araz L. Rahim b
Trifa A. Mahmood a,b, Mohammed O. Mohammed a,b, Dana T. Gharib b, Taha A. Mohamad a,b, Muhsin A. Mohammed b, and Araz L. Rahim b
a College of Medicine, University of Sulaimani, Kurdistan Region, Iraq.
b Kurdistan Centre of Gastroenterology and Hepatology (KCGH), Sulaymaniyah, Kurdistan Region, Iraq.
Submitted: 15/2/2020; Accepted: 30/6/2020; Published: 21/3/2021
DOI Link: https://doi.org/10.17656/jsmc.10285
ABSTRACT
Background
The difficulty in differentiating functional gastrointestinal disorders and inflammatory bowel diseases in patients presenting with abdominal symptoms direct us to the use of fecal inflammatory biomarkers that are specific to intestinal inflammation.
Objectives
To assess the benefits of fecal calprotectin (FC) in patients presenting with lower abdominal symptoms. Also, correlating the FC and CRP titer with abdominal pain severity.
Patients and Methods
Prospective cross-sectional study in Kurdistan Center for Gastroenterology and Hepatology (KCGH), Sulaimaniyah city, Northern Iraq. A total of 174 patients with IBS according to Rome IV criteria, who visited KCGH, met the inclusion criteria. FC titer measured before colonoscopy appointment, abdominal pain severity scored according to visual scale, and colonoscopy performed by a specialized gastroenterologist.
Results
The FC level was below 50ug/g for 91.3% of patients with normal endoscopy; all of the IBD cases had FC level above 100ug/g. Seven of the eight patients with non-inflamed polyp or diverticuli had an FC level of less than 50ug/g. Moreover, in this study, the CRP level is also significantly higher among IBD cases than in patients with normal colonoscopy.
Conclusion
FC titer is a useful measure before the decision for colonoscopy especially in cases not having alarm symptoms and other comorbidities. FC and CRP level is associated with the severity of abdominal pain.
KEYWORDS
Inflammatory bowel disease; Fecal calprotectin; Colonoscopy, Sulaimaniyah.
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