Jsmc-10294

ANTI-HYPERLIPIDEMIC AND WEIGHT REDUCTION EFFECT OF DIFFERENT DOSES OF FERULAGO ABBREVIATA C.C. (TOWNS (APIACEAE)) IN MALE ALBINO RATS

Mohammed Omer Muhammed a, Firduas Nuri Ahmed b, Hemn Hassan Othman c, and Saman Abdulrahman Ahmad d

a College of Medicine, University of Sulaimani, Kurdistan Region,Iraq

b University of Human Development, Ministry of Health, Kurdistan Region, Iraq

c College of Pharmacy, University of Sulaimani, Kurdistan Region, Iraq

d College of Agriculture, University of Sulaimani American University in Sulaimani, Kurdistan Region, Iraq

Submitted: 1/7/2020; Accepted: 22/11/2020; Published: 21/6/2021

DOI Link: https://doi.org/10.17656/jsmc.10294

ABSTRACT

Background

A large number of studies on the active compound of herbal medicine proved that plant extract is very effective and safe in patients especially in hyperlipidemia, regarding the International Lipid Expert Panel (ILEP), pharmaceutical compounds containing herbal monomers and derivatives are very effective and safe in the treatment of hyperlipidemia and reducing body weight, for example, onion, garlic, flaxseed oil, celery and Ferulago angulate (Schltdl.) Boiss Ferulago abbreviata C.C. Towns. (Apiaceae; Kurdish: Chnor) are another species of the family of Apiaceae used in this study to investigate their effect on the serum lipid profile and body weight.

Objectives

Evaluation and comparing effect of different doses of Ferulago Abbreviata as anti-hyperlipidemia, and weight reduction.

Materials and Methods

We divided fifteen male albino rats into 3 equal groups(n=5) as follows: (group HFD, FA500, and FA700), collected blood from them and weighted each of them as a baseline, then after six weeks fed a high-fat diet (HFD) to all the groups collected blood and weighted again, and started different regimens of treatment until week ten as follows: HFD group: received a fat-rich diet only; FA500 group: received a fat-rich diet, plus extracts of Ferulago abbreviata at a dose of 500mg/kg; FA700 group: received a fat-rich diet, plus extracts of Ferulago abbreviata at a dose of 700mg/kg. At the end of the study, we collected the blood for investigation of the level of lipid profile and weighted them.

Results

By added extract of Ferulago abbreviate to hyperlipidemic rats the level of cholesterol, TG, LDL, VLD, Atherogenic index and body weight were significantly reduced and HDL level elevated, this finding was significant, also the high dose of the plant considerably very effective in lowering the lipid profile but in reducing the weight of the rats has the same result of a lower dose.

Conclusion

Using hydro-alcoholic extracts of Ferulago abbreviata can decrease the lipid profile and weight very significantly.

KEYWORDS

Natural product, Ferulago abbreviata, Anti-hyperlipidemia, weight gain.

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