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The development of breakdown in the mucosa of the stomach leading to ulceration. PUD is characterized by pain that is often relieved temporarily by eating or antacids, but recurs between meals and at night.
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Tools + Resources
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Student Guide
Student Guide
PUD (4).pdfTest Your Knowledge
Test Your Knowledge
Which of the following statements regarding PUD is FALSE?
a) A peptic ulcer forms in the mucosal lining of the stomach or duodenum when there is an imbalance in gastric acid and pepsin
b) H. pylori can cause inflammation which leads to cell damage and ulceration
c) NSAIDs inhibit COX-1 which increase prostaglandin secretion to promote mucosal buildup
d) Endoscopy with biopsy is the gold standard for PUD diagnosis
All of the following may be signs/symptoms of PUD except?
a) Heartburn
b) No symptoms
c) Nausea/vomiting
d) Hematochezia
Which of the following has the best evidence for eradicating H. pylori infection?
a) dexlansoprazole BID + amoxicillin BID + metronidazole BID + clarithromycin BID x 14 days
b) ranitidine BID + amoxicillin BID + metronidazole BID + clarithromycin BID x 14 days
c) pantoprazole BID + bismuth subsalicylate QID + metronidazole TID + tetracycline QID x 14 days
d) omeprazole BID + clarithromycin BID + amoxicillin BID x 14 days
Which of the following statements regarding PUD treatment is TRUE?
a) PPIs have a 95% efficacy rating for healing ulcers
b) sucralfate forms a barrier over the ulcer to promote healing
c) misoprostol is less effective than PPIs for healing ulcers
d) All of the above
When would prophylactic therapy for NSAID-induced ulcers be indicated?
a) History of PUD or upper GI bleed
b) Concomitant corticosteroid use
c) Age > 65
d) All of the above
Answer Key
Answer Key
c
d
a
b
d
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