16.01.5 Sucralfate

After acid has damaged the lining of the intestine, pepsin can digest the mucosal proteins, and this contributes to mucosal erosion and ulceration. In an acidic environment, sucralfate produces a viscous, sticky gel. This gel sticks to ulcers to inhibit digestion of mucosal proteins. Antacids will prevent sucralfate from working, and should not be taken at the same time. By lining the intestine, sucralfate can prevent the absorption of some drugs (e.g. phenytoin, digoxin). To avoid this, sucralfate should be taken after other drugs. Sucralfate is occasionally used to treat ulcers.