15.06.3 Other uses of oestrogens and progestogens

The oestrogens are also used in disorders of menstruation (e.g. endometrial hyperplasia), in prostate cancer, and in hirsutism (excessive androgen-dependent hair growth).

Oestrogens and progestogens are used together as hormone replacement therapy (HRT). HRT is a combination of a low dose of an oestrogen, such as oestradiol, and a progestogen, usually medoxyprogesterone acetate. HRT can be used relatively safely for up to 5 years to relieve moderate-severe menopausal symptoms. The progestogen is mainly used to prevent endometrial cancer with the oestrogen. In women that have had a hysterectomy (removal of the uterus), oestrogen is safe and effective alone in preventing menopausal symptoms.