03. Pharmacodynamics
Sheila A Doggrell
School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Gardens Point, GPO Box 2434, QLD 4001, Australia
Phone +61 7 38705741 Fax +61 7 31381534 Email sheila.doggrell@qut.edu.au
Reviewer required
Key words: drug binding sites, enzymes, acetylcholinesterase, cyclooxygenase, ion channels, sodium channels, transporter, serotonin transporter, fluoxetine, pumps, proton pump, receptors, G-protein coupled receptors, intracellular receptors, agonism, cell signaling, antagonism, cytotoxic anti-cancer drugs, targeted anti-cancer drugs
Contents
3.1 Pharmacodynamics – enzymes, ion channels, transporters and pumps
3.1.1 Introduction to pharmacodynamics
3.1.2 Drug binding sites
3.1.3 Enzymes
3.1.3.1 Inhibition of acetylcholinesterase
3.1.3.2 Inhibition of cyclooxygenase
3.1.4 Ion channels
3.1.4.1 Introduction
3.1.4.2 Inhibition of sodium channels
3.1.5 Transporters
3.1.5.1 Introduction
3.1.5.2 Inhibition of the serotonin transporter
3.1.6 Pumps
3.1.6.1 Inhibition of the proton pump
3.2. Pharmacodynamics – receptors and cell signalling, and ant-cancer drugs
3.2.1 Receptors
3.2.1.1 G-protein coupled receptors
3.2.1.2 Intracellular receptors
3.2.2 Agonism
3.2.2.1 Introduction to agonism and antagonism
3.2.2.2 Full, partial and inverse agonism
3.2.2.3 Potency and selectivity of agonist
3.2.3 Cell signaling
3.2.4 Antagonism
3.2.4.1 Competitive reversible
3.2.4.2 Functional
3.2.5 Anti-cancer drugs
3.2.5.1 Cytotoxic anti-cancer drugs
3.2.5.2 Targeted anticancer drugs
Drugs are used to have an effect on the body and, hopefully, this effect is beneficial. The process of drugs altering things in the body is known as pharmacodynamics. Pharmacodynamics includes the mechanism of action of the drug, and the resulting actions in the body. By knowing the mechanism of action of a drug, we can often predict the actions in the body, and the resulting clinical uses of a drug. Also, by knowing the mechanism of a drug, we can often predict the adverse effects it will have.