10.02.3.5 Leukotriene Receptor Antagonists
Montelukast is a leukotriene receptor antagonist that is used in the prevention of asthma. It antagonises the LTC4, LTD4, and LTE4 receptors to reduce bronchoconstriction and inflammation.
10.3 5-Hydroxtryptamine (serotonin), nitric oxide, and endothelin
The final 3 local chemical mediators to be discussed briefly, with respect to therapeutics, are 5-hydroxytryptamine (5-HT, also known as serotonin), nitric oxide (NO), and endothelin. 5-HT is a neurotransmitter and a local chemical. 5-HT1 receptor subtypes and 5-HT2 receptors are involved in migraine, whereas 5-HT3 and 5-HT4 receptors are involved in gastrointestinal motility.