Homocysteine, folate, and vitamins B6 and B12 were measured in preconception plasma. Relative to women in the lowest quartile of vitamin B6, those in the third and fourth quartiles had higher odds of conception (odds ratio = 2.2; odds ratio = 1.6, respectively), and the adjusted odds ratio for early miscarriage in conceptive cycles was lower in the fourth quartile (odds ratio=0.5). Women with sufficient vitamin B6 had higher odds of conception (odds ratio = 1.4) and a lower adjusted odds ratio of early miscarriage in conceptive cycles (odds ratio=0.7) than did women with vitamin B6 deficiency. Poor vitamin B6 status appears to decrease the probability of conception and to contribute to the risk of early miscarriage in this population.
folate, vitamins B2, B6, and B12, were lower in miscarriage cases compared to the controls, although the difference did not reach significance except for vitamin B6 intake, which resulted in the border of significance (2.1 vs. 1.8 mg). It is important to point out that multivitamin supplementation is low in the Mexican population, as was the case in this small study population. Thus, these findings need to be replicated in larger studies to fully evaluate the protective role of these vitamins on miscarriage risk.
stress) on fetal growth.
prolactin, a hormone that causes testosterone to be taken up by tissues.
progesterone-like effect but it does not intensify the action of progesterone. On the other hand, vitamin B12 and vitamin A exhibit no progesterone-like effect and do not affect the action progesterone when they were given together.
estrogen, increases progesterone and results in improved symptoms under double-blind conditions.
HbA1c levels decreased after 6 wk of treatment with 150 mg/day vitamin B6.
There was a strong dose-response relation of plasma vitamin B6 concentration with plasma C-reactive protein. Increasing quartiles of vitamin B6 were significantly associated with lower C-reactive protein concentrations (geometric means: 4.7, 3.6, 3.1, and 2.5 mg/L) and with lower oxidative DNA damage (geometric means: 124, 124, 117, and 108 ng/mg creatinine) after multivariate adjustment. These negative associations persisted after plasma homocysteine was controlled for. Plasma vitamin B6 concentrations were significantly negatively correlated with plasma fasting glucose, glycated hemoglobin, and homeostasis model assessment of beta cell function. Metabolic syndrome, obesity, and diabetes were also significantly associated with low plasma vitamin B6 concentrations. CONCLUSIONS: Low vitamin B-6 concentrations are associated with inflammation, higher oxidative stress, and metabolic conditions in older Puerto Rican adults.
blood coagulation of rabbits. Platelet aggregations induced with different agonists were assessed in platelet-rich plasma with vitamin B6 from 0 to 3.0 mM. Vitamin B6 significantly inhibited platelet aggregation to different agonists at the final concentration of 0.6 mM and reached the plateau of inhibition at 1.8mM. These results suggested that vitamin B6 displayed antiplatelet and anticoagulation action in rabbits at around 0.36 to 1.8 mM plasma level.