Vitamin B6

Vitamin B6 and Miscarriage

High vitamin B6  lowers chance of miscarriage by 50% improves fertility by 120%

Homocysteine, folate, and vitamins B6 and B12 were measured in preconception plasma. Relative to women in the lowest quartile of vitamin B6, those in the third and fourth quartiles had higher odds of conception (odds ratio = 2.2; odds ratio = 1.6, respectively), and the adjusted odds ratio for early miscarriage in conceptive cycles was lower in the fourth quartile (odds ratio=0.5). Women with sufficient vitamin B6 had higher odds of conception (odds ratio = 1.4) and a lower adjusted odds ratio of early miscarriage in conceptive cycles (odds ratio=0.7) than did women with vitamin B6 deficiency. Poor vitamin B6 status appears to decrease the probability of conception and to contribute to the risk of early miscarriage in this population.

Vitamin B6, B2, B12 and folate lower in women who miscarry

The median levels of all B vitamins examined, i.e. folate, vitamins B2, B6, and B12, were lower in miscarriage cases compared to the controls, although the difference did not reach significance except for vitamin B6 intake, which resulted in the border of significance (2.1 vs. 1.8 mg). It is important to point out that multivitamin supplementation is low in the Mexican population, as was the case in this small study population. Thus, these findings need to be replicated in larger studies to fully evaluate the protective role of these vitamins on miscarriage risk.

Vitamin B6 can prevent stress from affecting fetal growth

High-dose vitamin B6 may counteract the adverse impact of glucocorticoids (which are increased by stress) on fetal growth.

Vitamin B6 and Hormones

Vitamin B6 lowers prolactin

Vitamin B6 appears to reduce the production of prolactin, a hormone that causes testosterone to be taken up by tissues.

Vitamin B6 acts similarly to progesterone

Vitamin B6 possesses progesterone-like effect but it does not intensify the action of progesterone. On the other hand, vitamin B12 and vitamin A exhibit no progesterone-like effect and do not affect the action progesterone when they were given together.

Vitamin B6 increases progesterone

Administration of vitamin B6 at doses of 200-800 mg/day reduces blood estrogen, increases progesterone and results in improved symptoms under double-blind conditions.

Vitamin B6 lowers aldosterone and reduces water retention

Vitamin B6 at high dosage suppresses aldosterone (a hormone that increases the reabsorption of sodium and water and the release of potassium in the kidneys, increasing blood volume and, therefore, blood pressure) and results in diuresis and clinical improvement.

Vitamin B6 and Insulin Resistance

150 mg vitamin B6 improves insulin resistance

HbA1c levels decreased after 6 wk of treatment with 150 mg/day vitamin B6.

Vitamin B6 lowers insulin resistance, oxidative DNA damage, and C-reactive protein

There was a strong dose-response relation of plasma vitamin B6 concentration with plasma C-reactive protein. Increasing quartiles of vitamin B6 were significantly associated with lower C-reactive protein concentrations (geometric means: 4.7, 3.6, 3.1, and 2.5 mg/L) and with lower oxidative DNA damage (geometric means: 124, 124, 117, and 108 ng/mg creatinine) after multivariate adjustment. These negative associations persisted after plasma homocysteine was controlled for. Plasma vitamin B6 concentrations were significantly negatively correlated with plasma fasting glucose, glycated hemoglobin, and homeostasis model assessment of beta cell function. Metabolic syndrome, obesity, and diabetes were also significantly associated with low plasma vitamin B6 concentrations. CONCLUSIONS: Low vitamin B-6 concentrations are associated with inflammation, higher oxidative stress, and metabolic conditions in older Puerto Rican adults.

Vitamin B6 and Blood Coagulation

Vitamin B6 reduces blood coagulation

The optimal level of vitamin B6, in the form of pyridoxal-5-phosphate, on the antithrombotic effect was investigated in the platelet function and blood coagulation of rabbits. Platelet aggregations induced with different agonists were assessed in platelet-rich plasma with vitamin B6 from 0 to 3.0 mM. Vitamin B6 significantly inhibited platelet aggregation to different agonists at the final concentration of greater-than over equal to 0.6 mM and reached the plateau of inhibition at greater-than over equal to 1.8mM. These results suggested that vitamin B6 displayed antiplatelet and anticoagulation action in rabbits at around 0.36 to 1.8 mM plasma level.