GnRH

Reducing GnRH improves egg quality and improves fertilization rate by 23%

Early and short follicular GnRH antagonist supplementation using flexible GnRH antagonist treatment improves the meiotic status and competence of retrieved oocytes. Women in the study group were additionally supplemented with three injections of GnRH antagonist (0.25 mg/d on days 1, 2, and 3 of the menstrual cycle). Both groups had comparable baseline characteristics. The fertilization rate was significantly higher in the study as compared with the control group (85% and 69%, respectively). Moreover, the cumulative rate of mature first polar body oocytes was significantly higher in the study group as compared with the control group (93% and 85%, respectively). Concomitantly, day-3 FSH and LH levels after initiation of treatment were significantly lower in the study as compared with the control group (6.1 mIU/mL vs. 7.2 mIU/mL and 2.4 mIU/mL vs. 5.6 mIU/mL, respectively).

http://www.fertstert.org/article/S0015-0282(09)03508-0/abstract


Dairy products may lower GnRH

Morphine suppresses the proestrous surge of GnrH in pituitary portal plasma of rats (casomorphins from digested dairy products act similarly to morphine in the body).

http://www.ncbi.nlm.nih.gov/pubmed/6406211

Dairy and Miscarriage


Vitex lowers GnRh, LH and FSH

Another mechanism through which vitex agnus castus may work is the opiate system, which consists of u, s, and k opiate receptors andendogenous opiate peptides such as beta-endorphin. This peptide assists in regulating the menstrual cycle through inhibition of the hypothalamus–pituitary–adrenal axis (HPA), therefore decreasing the amount of gonadotropic releasing hormone (GnRH) acting on the pituitary, which decreases the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH).

http://linkinghub.elsevier.com/retrieve/pii/S0378874105008457


Insulin increases GnRH

Hyperinsulinemia increases GNRH pulse activity leading to disorderly LH and FSH activity, as seen in Polycystic ovary syndrome (PCOS).

http://en.wikipedia.org/wiki/Gonadotropin-releasing_hormone

Insulin Resistance and Miscarriage

As progesterone decreases, GnRH rises and causes stimulation of LH and FSH. FSH causes maturation of follicles past the antral stage. The dominant follicle establishes itself and is the main follicle that grows. The growing follicle produces estrogen in the granulosa cells. Estrogen actually peaks before heat (estrus) and it is the estrogen that causes the final LH release.


Other topics covered under Hormones:

Adiponectin, Estrogen, FSH, GnRH, LH, PCOS, Progesterone, Prolactin, SHBG, Testosterone