Selenium

μg/L, resp.). It has therefore been suggested that reduced selenium concentration results in reduced glutathione peroxidase activity culminating in reduced antioxidant protection of biological membranes and DNA during the early stages of embryonic development. Although speculative, and requiring larger placebo-controlled randomised trials, women with recurrent early miscarriage may benefit from optimisation of selenium status.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171895/?tool=pubmed

Selenium levels in women with recurrent miscarriage were similar to controls

The mean selenium concentration for women with a history of unexplained recurrent miscarriage was 67.7 microg/L (SD 16.4). The selenium level for the women with no history of recurrent miscarriage was 70.3 microg/L (SD 12.7). There was no difference in selenium concentrations between the two groups.

http://www.ncbi.nlm.nih.gov/pubmed/10549965

Selenium levels in women who miscarried did not differ from women with continuing pregnancy

The selenium concentrations in whole blood and plasma of women following miscarriage were the same as in viable pregnancy, but were significantly lower compared with controls.

http://www.ncbi.nlm.nih.gov/pubmed/11281462

Selenium and Hormones

Selenium supplementation increases progesterone

Selenium supplementation did not affect the length of the estrous cycle, but it did increase the concentration of plasma progesterone in the estrous cycle . These results suggest the possibility that selenium contributes to the progesterone production of corpus luteum.

http://www.ncbi.nlm.nih.gov/pubmed/9492375

Selenium and Thyroid

Selenium added to thyroxidine therapy led to reduced antibody levels

Selenium supplementation (50-100 microg/day) and thyroxidine therapy resulted in an increase in plasma glutathione peroxidase (GPX3) by 21%. Anti-thyroid peroxidase antibody levels decreased by 76%.

http://cat.inist.fr/?aModele=afficheN&cpsidt=20987744

Thyroid and Miscarriage

200 mcg selenium reduced thyroid antibodies by 21%

Selenium supplementation (200 microg/day) resulted in significant reduction of serum anti-TPO levels during the first 6 months (by 5.6% and 9.9% at 3 and 6 months, respectively). An overall reduction of 21% was seen after 1 year.

http://www.ncbi.nlm.nih.gov/pubmed/17696828

200 mcg selenium during pregnancy prevented hypothyroidism

Postpartum thyroid dysfunction and permanent hypothyroidism were significantly lower in the group that received 200 microg/d throughout pregnancy and the postpartum period compared with placebo (28.6 vs. 48.6%; and 11.7 vs. 20.3%).

http://www.ncbi.nlm.nih.gov/pubmed/17284630

Selenium reduces inflammatory cytokines in autoimmune thyroid patients

Our objective was to compare the effect of selenomethionine (organic form of selenium available over the counter) on monocyte and lymphocyte cytokine release and systemic inflammation in patients with Hashimoto's thyroiditis. Selenomethionine inhibited lymphocyte release of IL-2, interferon-γ, and TNF-α, which was accompanied by a reduction in plasma C Reactive Protein levels. CONCLUSIONS: Selenomethionine exhibits a systemic antiinflammatory effect in euthyroid females with Hashimoto's thyroiditis. This action, which correlates with a reduction in thyroid peroxidase antibody titers, may be associated with clinical benefits in the prevention and management of Hashimoto's thyroiditis, particularly in subjects receiving both agents.

http://www.ncbi.nlm.nih.gov/pubmed/21508145

Selenium Daily Upper Limit

300 mcg/day selenium is toxic

It has been shown that dietary intake of about 300 micro g of selenium daily may have a toxic effect on growth hormone and insulin like growth factor-1 metabolism, as well as in the synthesis of thyroid hormones.

http://www.ncbi.nlm.nih.gov/pubmed/17160166

Other topics covered under Vitamins:

Biotin, Calcium, Choline, Chromium, Folic Acid, Magnesium, Multivitamins, Phosphorus, Selenium, Vitamin A, Vitamin B12, Vitamin B6, Vitamin C, Vitamin D, Vitamin E, Vitamin K, Zinc