Adiponectin and Fertility

Higher adiponectin levels is associated with better fertility

Adiponectin, a beneficial adipokine, represents a major link between obesity and reproduction. Higher levels of adiponectin are associated with improved menstrual function and better outcomes in assisted reproductive cycles.

High adiponectin negatively associated with fetal growth

Women with singleton pregnancy, between 12th and 14th weeks, were included to the study. The percentiles of fetal crown-rump length were negatively associated with the adiponectin and insulin plasma concentrations. Also there were correlation between fetus crown-rump length percentile and the insulin sensitivity and the ratio of adiponectin to leptin concentration. Conclusions: The results of this study imply that adiponectin and insulin maternal plasma concentration may have a role in early determination of fetal growth.

The percentiles of fetal crown-rump length (CRL) were negatively correlated with adiponectin plasma concentration, with no relation to leptin and insulin plasma concentration. Correlations between fetus crown-rump length percentile and the ratio of adiponectin to leptin concentration and adiponectin to insulin resistance index were also observed. No association between adiponectin, leptin, fasting insulin, HOMA-IR and neonatal birth weight or birth weight percentile was found. The percentile of fetal CRL in the 1st trimester was positively correlated with neonatal birth weight percentile. The results of this study imply that maternal adiponectin concentration may play a role in early determination of fetal growth.

How to Increase Adiponectin

Higher adiponectin levels improve insulin sensitivity; levels go up as body weight goes down

Adiponectin is a protein hormone that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism. Adiponectin is exclusively secreted from adipose tissue into the bloodstream and is very abundant in plasma relative to many hormones. Levels of the hormone are inversely correlated with body fat percentage in adults, while the association in infants and young children is less clear. The hormone plays a role in the suppression of the metabolic derangements that may result in type 2 diabetes, obesity, atherosclerosis, non-alchoholic fatty liver disease (NAFLD) and an independent risk factor for metabolic syndrome.

Soy increases adiponectin

Diet, physical exercise and daily oral intake of a soy isoflavones extract (Fisiogen((R))) contained 200mg of Glycine max, which corresponded to 80mg of isoflavone (60.8mg of genistein, 16mg of daidzein and 3.2mg of glicitein) have a beneficial effect on serum leptin, adiponectin and TNF-alpha in healthy obese postmenopausal women after 6 months of treatment. Mean serum leptin and TNF-alpha levels declined after 6 months in both groups of the study, but only women in the soy isoflavones group showed a significant increase of mean serum levels of adiponectin.

Negative mood associated with low adiponectin

In premenopausal women, negative mood and nocturnal urinary epinephrine were significantly related to adiponectin, independent of BMI.

Adiponectin decreases with higher waist to hip ratio and insulin resistance

Adiponectin was significantly higher in normal weight (14.7 microg/mL) compared with overweight (9.9 microg/mL) women. Leptin was independently and negatively related to plasma adiponectin in the overall study group. Plasma adiponectin was only related to trunk fat-leg fat ratio (inversely related) among normal weight subjects, whereas plasma adiponectin was positively related to fat-free mass and negatively related to insulin resistance among overweight women.

Consuming omega 3's increases adiponectin

A lipidomic analysis with liquid chromatography/mass spectrometry/mass spectrometry revealed that omega-3-PUFAs induced adiponectin expression (apidonectin boosts insulin sensitivity and weight loss) to a similar extent that of rosiglitazone, a member of the thiazolidinedione family of antidiabetic drugs.

Exercise boosts adiponectin by 160%

Twenty-six overweight males participated in an exercise program. Exercise consisted of aerobic exercise (brisk walking mixed with light jogging) 4–5 days per week for 40 min per session (∼55–70% V2max) over 10 weeks. Adiponectin levels rose by 260% after two to three bouts of exercise (∼1 week) (7.0 ± 0.7 vs. 18.2 ± 1.9 μg/ml) despite unchanged body weight and remained elevated (16.4 ± 1.9 μg/ml) after 10 weeks.

Other topics covered under Hormones:

Estrogen, FSH, GnRH, LH, PCOS, Progesterone, Prolactin, SHBG, Testosterone