[Member] 강창수 Rheumatology 논문에 대한 Editorial이 6월호에 게재 (4월 26일 웹게재)

Post date: Mar 8, 2016 6:32:57 AM

강창수 박사가 Rheumatology 4월호에 게재 (2월 3일 웹게재) 하였던 논문 "The influence of a Polymorphism at Position -857 of the Tumor Necrosis Factor a Gene on Clinical Response to Etanercept Therapy in Rheumatoid Arthritis"에 대해서 집중적으로 다룬 Editorial 이 Rheumatology 6월호에 게재 (4월 26일 웹게재) 되었습니다.

http://rheumatology.oxfordjournals.org/cgi/content/full/44/6/705

네댈란드 암스텔담대학교의 N. de Vries와 P. P. Tak이 공동으로 저술한 Editorial은 강창수 논문의 의의와 중요성에 대해서 3 페이지에 걾쳐 상세히 소개하였습니다. 이 논문에 대해 "...an intelligent approach" 사용하였으며 "...this study may well be one of the early birds in the next wave of genetics..." 라고도 하였습니다. 또한 이 논문이 두 가지면에서 흥미롭다고 하였다.

첫째 "... these data are interesting since they support the notion that individuals predisposed to high TNF production show worse responses to anti-TNF- therapy."

둘째 "... concerning itself with interpretation of gene regulation rather than with polymorphisms of coding sequences or with gene expression itself."

결론으로, "... taken together the data produced do support the idea that genetic variations in the promoter site of the TNF- gene that are associated with low inducibility of TNF- production are also associated with a good response to anti-TNF- treatment. Furthermore, the observed effects are well explained by the previously described intriguing interactions between the transcription factors OCT1 and the different NFB variants upon binding to the regulatory DNA sequences upstream of the TNF- gene. These data indicate that modulation of these interactions might be an interesting goal for future therapies. For doctors currently working at the bedside, the data presented raise the question of whether treatment with higher than standard doses of anti-TNF- therapy might be needed for patients with high-TNF- producing genotypes."라고 맺었다.