[Member] 강창수 박사, Nature Genetics 논문 공동 저자

Post date: Mar 8, 2016 5:31:09 AM

일본 RIKEN/동경의대 Yamamoto 교수의 의뢰를 받아 우리가 한양대 배상철 교수 연구팀이 제공한 한국인 샘플들의 haplotype을 분석한 결과가 포함된 논문이 Nature Genetics에 Advance Online Publication으로 4월 17일 (한국시간 18일 2시)에 발표되었습니다. 논문은 http://dx.doi.org/10.1038/Ng1540에서 다운 받을 수 있습니다.

Nature의 언론 보도 자료: "Genetic basis of autoimmune diseases"

A gene associated with susceptibility to a group of autoimmune diseases, including rheumatoid arthritis, thyroid disease and lupus, is identified in the May issue of Nature Genetics. This discovery is the latest in a series of findings identifying common genetic variants as risk factors for more than one disorder in which the immune system attacks the body's own tissues.

Ryo Yamada and colleagues found that a particular variant of the gene FCRL3, encoding a receptor that may be involved in regulating the immune system, is significantly more common in Japanese individuals with one of these autoimmunities. The variant affects the binding of a factor, NF-kB, which promotes FCRL3 expression, resulting in greater production of both FCRL3 and certain autoantibodies.

These autoantibodies are well known markers for rheumatoid arthritis in particular. The findings were replicated in an independent Japanese group, lending confidence to the results, although it remains to be seen whether the association will also be observed in other ethnic groups.