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Post date: Nov 25, 2014 2:50:16 PM
1. Moderate-to-severe COPD analysis
- Planning for a ' Phase 1' analysis - not all groups in the ICGC are included (e.g. Deb does not have all her genotyping yet) - but all realize need to move forward
- Data to be received from ARIC soon
- Less enthusiasm for including prior results from Wilk et al given analysis issues (different phenotype)
- However, will reach out to other cohorts with reasonable number of mod-severe COPD cases from CHARGE (e.g., Framingham, CHS, Rotterdam)
- Planning call with Kathleen Barnes to discuss obtaining LungHealth data and appropriate controls (from similar generation illumina chip - ?CHS)
- For LungHealth and other longitudinal cohorts, discussed challenges of working with longitudinal data - which time point is taken?
- Marike working on COPACETIC GWAS
- Steve points out issue with using pre-bronchodilator spirometry -- hopefully a minor problem; evidence of consistent effect direction / replication in the Wilk et al analysis
2. Other analysis
- MB interested in GxE, nonsmoker COPD, and lung function
- Yohan can provide lookup of eQTL results - this will be very useful
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