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Post date: Oct 27, 2014 5:01:29 PM
1. Case-control analyses
- Many cohorts agreeing to participate in R01 submission (thanks, all)
- Discussed that current analysis behind schedule - instead of waiting for additional cohorts, agreement to proceed with what is currently available
- Reaching out to CHARGE cohorts for results from existing analyses
- Identifying controls for LungHealth / ECLIPSE - challenging. ?need to discuss with others who have experience?
- Case-control by spirometry may misclassify - controls with emphysema
2. Next analyses
- Enthusiasm for other phenotypes
- FEV1 in cases - Deb Meyers - determinants of disease and disease severity different for asthma
- Imaging - discordances between PFT severity and emphysema (subsetting approach - Eric Hoffman) or as quantitative trait
- Inflammatory biomarkers (John Newell). ?presence of vascular endothelial biomarkers (e.g. EMPs in MESA). Cohort details have some info on biomarkers available (and can ask specific contacts to drill down).
- GxE - challenging, might be useful. Cigarette smoking in all cohorts, other environment exposures e.g. MESA Air
- Other phenotypes - e.g. mentioned hpv (hypoxic pulm vasocontrction) - likely small number of subjects
- Project proposal form for additional studies are here .
Next call Nov 24th 11AM EST
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