Genetics Call 2014-10-27

Post date: Oct 27, 2014 5:01:29 PM

1. Case-control analyses

- Many cohorts agreeing to participate in R01 submission (thanks, all)

- Discussed that current analysis behind schedule - instead of waiting for additional cohorts, agreement to proceed with what is currently available

- Reaching out to CHARGE cohorts for results from existing analyses

- Identifying controls for LungHealth / ECLIPSE - challenging.  ?need to discuss with others who have experience?

- Case-control by spirometry may misclassify - controls with emphysema

2. Next analyses

- Enthusiasm for other phenotypes

- FEV1 in cases - Deb Meyers - determinants of disease and disease severity different for asthma

- Imaging - discordances between PFT severity and emphysema (subsetting approach - Eric Hoffman) or as quantitative trait

- Inflammatory biomarkers (John Newell).  ?presence of vascular endothelial biomarkers (e.g. EMPs in MESA).  Cohort details have some info on biomarkers available (and can ask specific contacts to drill down).

- GxE - challenging, might be useful.  Cigarette smoking in all cohorts, other environment exposures e.g. MESA Air

- Other phenotypes - e.g. mentioned hpv (hypoxic pulm vasocontrction) - likely small number of subjects

- Project proposal form for additional studies are here .

Next call Nov 24th 11AM EST