Genetics Call 2016-6-27

Post date: Jul 6, 2016 5:32:55 PM

Confirmed present: Hobbs, Busch, Bosse, Sparrow, Gharib, Cho, Beaty, Lahousse

Case Control Manuscript Updates:

-Plan to submit the manuscript this week to Nature Genetics, as a letter or communication. Has required significant re-formatting. Next target journal unclear. Sina suggests that Nat Communications could be a good option; impact factor is similar to AJRCCM but it is new so likely rising

-Co-localization work with eQTL group seems to be helpful

- Emphysema Analysis Plan:

    -Confirmed involved datasets with people on the call.  Called for anyone else who believes they should be involved to contact Mike.  Overall log950 seems to be best bet, better scaling, more interpretable.

    -Called to generate histograms for each cohort to examine them within the cohorts, as well as baseline characteristics (i.e. table 1 information).  Marike confirms that this is likely feasible

    -Timeline for Histograms - still shooting for July 18th as the deadline

    -Timeline for Analyses - as per documentation sent out previously

Other Projects:

- Peter, Yohan, and others will apply a lung eQTL analysis to the ICGC meta-analysis to identify new genes in     COPD.  Will try to get data to them after submission

- ‘Overlap’ proposal tentatively with collaboration with IPF investigators

- Reviewed mechanisms for submitting new proposals, submission form is on the website