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Post date: Sep 17, 2015 12:31:11 PM
Many people at ERS. Thanks if you joined the call..
1. Case control / Severe / FEV / primary analysis
- Have 'final' results from everyone, after some updates / corrections
- Missing baseline data from some cohorts, imputation from Lovelace, ?RS2.
- Will reach out to individuals for this data
- All groups contributed to the moderate COPD analysis, most with sufficient sample sizes contributed to the severe, many also contributed to the FEV1 analysis but many also missing
- Circulate QC info to participating investigators - will ask each group if they do NOT want these results circulated first
- Plan to 'confirm' at least the top findings with independent analysis, will discuss with Marike
2. Further analysis
- Have discussed eQTL with Yohan
- Several other steps for a GWAS -- will draft an analysis plan and circulate: individuals may want to contribute a particular analysis to this paper, or the topic may be 'big' enough for a separate paper
3. Replication
- Have available 'candidate gene' and some top results from prior (e.g. RIN3) GWAS in additional cohorts that were added on to an exome array (exome array analysis presented at ATS 2015). Seems reasonable to use this as a replication / meta-analysis cohort.
Next call, Oct 26th.
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