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Post date: Aug 31, 2015 3:45:02 PM
Case control / severe / FEV analysis updates:
1. SPIROMICS allele frequencies fixed. Problem identified with MESA, they are rerunning. Prelim results without mesa show some of the usual suspects for COPD and for lung function (reassuring), some potentially new borderline associations. Similar for the severe analysis. FEV1 analysis in cases is somewhat disappointing.
2. Plan for analysis of GWAS results likely will include eQTL, other analyses (eg gene set , pathway) - please send over ideas if interested
3. Please fill out / confirm your baseline characteristics - google sheet is here (under ICGC - Genetics - Project Documents):
Emphysema analysis: many issues with trait transformation and group heterogeneity - discussion in progress. Steve brings up that is an important general problem to solve -- practical approach for pooling studies, e.g. optimal methods, quantitative estimates of increases in variance.
Next call September 28th.
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