Genetics Call 2016-8-29

Post date: Aug 29, 2016 3:58:44 PM

Present: Cho, Hobbs, Busch, Boezen, van Beek, Boss, Terzikhan, Sparrow, Silverman, Sakoda, Crapo, Beaty, Rennard

1) Case control update: opportunity to respond to Nature Genetics.  Main comment is about replication - 'necessary' per editor; discussion (Rennard) about how interpretation of P-values and arguments why adding replication (particularly in a smaller sample size) unhelpful - currently plan to discuss with groups that could replicate and discuss with the editor.  Other comments discussed, including fine mapping, additional LD score regression, asthma status of nonsmokers.

2) Emphysema: reviewing baseline phenotypes from groups: clarifying / updating analysis plan including transformation, CT scanner issues, and smoking (duration / intensity vs pack years).  Busch presented data on latter showing not much change; seems to be a reasonable argument also that py standard (Rennard).

3) Integrative genomics: Bossé- updates, reviewing with Vancouver group, also plan to do TWAS.

4) 'Overlap' proposal (Cho) - network scientist Sharma working on manuscript on fibrosis overlap

5) Nonsmoking COPD (Boezen): discussion about additional cohorts.

6) Administrative issues: ?consider changing time, or alternating times, given Monday frequently a holiday.  New website URL in process (copdconsortium.org).