Genetics Call 2015-7-27

Post date: Jul 27, 2015 3:21:27 PM

1. Case control analysis updates:

Continuing QC of GWASs: 

Have resolved QC / allele frequency issues with eQTL, KARE, MESA. 

Working on getting SPIROMICS allele frequencies.

Lovelace data is not imputed.

2. Severe

New cohorts will be CHS, EQTL, Lovelace, Rotterdam, and ARIC (pending: SPIROMICS).  All QC here looks OK.

3. FEV in cases:

Current cohorts  B58C, COPDGene, CHS, ECLIPSE, eQTL, FHS, Lovelace, GenKOLS, Rotterdam.

QC ongoing.

4. Emphysema analysis

Analysis plan still in discussion.   Major issues with trait transformation and ascertainment; will work on resolving these over the next few weeks.

Next call August 31st.