Genetics Call 2015-1-26

Post date: Mar 30, 2015 3:34:08 PM

1. Updates for moderate-to-severe COPD analysis

- ' Phase 1' analysis - existing cohorts - results received from ARIC.  Framingham and Rotterdam are amenable to redoing the analysis - conference call with Framingham to discuss has been scheduled.

- Marike will investigate COPACETIC results - ?have not been received?

- Kathleen Barnes agreed to share LungHealth data, comparing with controls from dbGap (?CHS)

- Deadline for analyses -- tentatively March 31, need to discuss with Fham and Rotterdam.  Once analyses received, estimate several more months to reconcile / QC meta-analysis results.  Will work in conjunction with Marike.

- Grant will be reviewed 2/19 by IRAP.

2. Other analyses

a. Emphysema: Fham, MESA, COPACETIC, performed over the summer, existing signals found, more significant.  Marike / Michael and others to discuss an upcoming meta-analysis. 

b. GxE, nonsmoker COPD - Marike is interested - will submit a ICGC proposal

c. Yohan is ready with eQTL results when we have identified our top signals.

Next call: Feb 23rd.