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Post date: Nov 28, 2016 4:47:04 PM
Present on call: Bossé, Cho, Hobbs, Lahousse, Beatty, Busch, Boezen, Sparrow
1. Project updates
a. Case control - now formally accepted. Thanks to everyone for their help.
Use of existing results - review of Stephanie's request.
b. ICGC emphysema - update from Rob. Still receiving analyses
c. Integrative genomics - update from Yohan.
Imputation done with HRC - 8e6, running TWAS, also colocalization. Using the GWAS 'gray zone' 10-4 (~200 loci) to find causal genes and new susceptibility loci.
d. Overlap - network methods, now looking at COPD with asthma.
2. New proposals -
Nonsmoking COPD (Marike): cohorts with ~20% of obstruction in non-smokers.
Job exposure: proposal circulated to those on call, interest in lung function / COPD interaction with exposures.
Marike will get approval from exec, and then circulate to get participants. David Sparrow points out that NAS has good data.
Emphysema distribution: proposal to be circulated / approved by Castaldi, Barr, and others.
'Next' case control proposal: will likely include Biobank; also other studies (?CANCOLD - Yohan is doing genotyping). Other studies not part of the initial ICGC proposal. Michael considering trying again to get funding to support some of these efforts.
What is the role for future studies in the context of larger lung function studies? Yohan also suggests PC analysis (http://www.nature.com/articles/ncomms13357)
3. Administrative issues -
Calls: no call next month (holidays); schedule to be sent for the upcoming year.
Organization: will try to discuss on next call, defining who is 'in' the ICGC, organizational structure.
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