Genetics Call 2015-10-26

Post date: Oct 26, 2015 3:34:51 PM

• Case-control, moderate to severe, severe; lung function - updates

  • Many people not able to make the call; email sent to at least one member of each cohort.

  • Would like to confirm additional authors -- guidelines up to 4 per cohort

  • QC: will plan to send around to review unless objections.  Outstanding issues are Lovelace imputation; LHS also plans to contribute a FEV1 analysis.

  • Meta-analysis: assuming QC is reasonable, should have independent analysis confirmation of at least the top associations

  • Additional analyses e.g. set/pathway, eQTL lookups, cross-ethnicity.

  • Replication vs additional power for discovery: additional cohorts genotyped by Ed Silverman / Channing including Early-Onset COPD, ICGN, TCGS.

  • Discussed with Martin Tobin: plan to take top associations and lookup for COPD in BiLeve

• Emphysema analysis

  • Still in process of deciding on analytic issues, which are myriad

  • Edwin Van Beek mentioned importance of looking at protocols: e.g. protocols that were close to COPDGene, SPIROMICS, ?MESA vs other low dose.  Would be instructive to compare distribution of %emphysema within a specific GOLD classification, and take a look at sample of individual histograms.