Phyllanthus niruri
Generalidades
Sinónimos: No aplican.
Nombre común: Iñoncillo, Quebra-pedra, Erva pombinha, Bahupatra, Bhuiamla, Bhuy amalaki, Niruri y Stone Breaker.
Características generales:
Es un pequeño arbusto que crece a una altura de 3 a 6 dm, silvestre, anual y de tallo erguido. Sus hojas son de 7 a 12 cm de largo, alternas, sésiles oblongas;
Flores pequeñas de color blanquecino-verdoso, solitarias, axilares, apétalas monoicas;
Sus frutos de 2 a 3 mm de diámetro, pequeños en una cápsula comprimida y globosa; raíz larga y poco ramificada;
Las semillas triangulares y verrucosas.
Usos medicinales reportados
Ampliamente usada en la medicina tradicional para favorecer la expulsión de cálculos renales o biliares, molestias de la vejiga, retención urinaria, diabetes, afecciones del hígado, como diurético.
Usos farmacológicos reportados
Contribuye a la eliminación de cálculos renales
Ayuda preservar función renal
Actividad hepatoprotector
Actividad antibacteriana
Actividad antidiabética
Actividad antitumoral
Actividad antiulcerosa
Actividad antioxidante
Actividad citotóxica
Actividad anticancerígena
Inducción de apoptosis
Inmunomodulación
Actividad antiviral
Bibliografías
PubMed
Lee NY, Khoo WK, Adnan MA, Mahalingam TP, Fernandez AR, Jeevaratnam K. The pharmacological potential of Phyllanthus niruri. J Pharm Pharmacol. 2016 Aug;68(8):953-69. doi: 10.1111/jphp.12565. Epub 2016 Jun 10. PMID: 27283048.
Pucci ND, Marchini GS, Mazzucchi E, Reis ST, Srougi M, Evazian D, Nahas WC. Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention. Int Braz J Urol. 2018 Jul-Aug;44(4):758-764. doi: 10.1590/S1677-5538.IBJU.2017.0521. PMID: 29617079; PMCID: PMC6092661.
Google Scholar
Yuniati, Y., Yuliati, L., Monica, E., & Rollando, R. (2019). Discovering anticancer compound of ethyl acetate extract from RL1 code endophytic fungi culture derived by Phyllanthus niruri Linn leaves through cell cycle modulation in T47d cells. IOP Conference Series: Materials Science and Engineering, 509, 012157. doi:10.1088/1757-899x/509/1/012157
Cao, X., Xing, X., Wei, H., Lu, W., & Wei, W. (2018). Extraction method and anti-cancer evaluation of two lignans from Phyllanthus Niruri L. Medicinal Chemistry Research, 27(8), 2034–2041. doi:10.1007/s00044-018-2212-y
Putri, D. U., Rintiswati, N., Soesatyo, M. H., & Haryana, S. M. (2017). Immune modulation properties of herbal plant leaves: Phyllanthus niruri aqueous extract on immune cells of tuberculosis patient - in vitro study. Natural Product Research, 32(4), 463–467. doi:10.1080/14786419.2017.1311888
Navarro, M., Moreira, I., Arnaez, E., Quesada, S., Azofeifa, G., Alvarado, D., & Monagas, M. (2017). Proanthocyanidin Characterization, Antioxidant and Cytotoxic Activities of Three Plants Commonly Used in Traditional Medicine in Costa Rica: Petiveria alliaceae L., Phyllanthus niruri L. and Senna reticulata Willd. Plants, 6(4), 50. doi:10.3390/plants6040050
Ooi, K. L., Loh, S. I., Sattar, M. A., Muhammad, T. S. T., & Sulaiman, S. F. (2015). Cytotoxic, caspase-3 induction and in vivo hepatoprotective effects of phyllanthin, a major constituent of Phyllanthus niruri. Journal of Functional Foods, 14, 236–243. https://doi.org/10.1016/j.jff.2015.01.032
Ali, H., Dixit, S., Alqahtani, S., Ali, D., Alkahtani, S., & Alarifi, S. (2015). Isolation and evaluation of anticancer efficacy of stigmasterol in a mouse model of DMBA-induced skin carcinoma. Drug Design, Development and Therapy, 2793. https://doi.org/10.2147/dddt.s83514
ScienceDirect
Ooi, K. L., Loh, S. I., Sattar, M. A., Muhammad, T. S. T., & Sulaiman, S. F. (2015). Cytotoxic, caspase-3 induction and in vivo hepatoprotective effects of phyllanthin, a major constituent of Phyllanthus niruri. Journal of Functional Foods, 14, 236–243. doi:10.1016/j.jff.2015.01.032
Chinwude, E. I., Roshan, K., Swati, J., Adeola, S. O., & Martins, E. (2014). Identification of sitosteryl glucoside palmitate in a chloroform-derived fraction of Phyllanthus niruri with antiplasmodial and peripheral antinociceptive properties. Asian Pacific Journal of Tropical Biomedicine, 4(9), 707–713. doi:10.12980/apjtb.4.2014apjtb-2013-0025
BioMed Research International
Zheng, Z.-Z., Chen, L.-H., Liu, S.-S., Deng, Y., Zheng, G.-H., Gu, Y., & Ming, Y.-L. (2016). Bioguided Fraction and Isolation of the Antitumor Components fromPhyllanthus niruriL. BioMed Research International, 2016, 1–7. doi:10.1155/2016/9729275
Dey, D., Chaskar, S., Bhatt, N., & Chitre, D. (2020). Hepatoprotective Activity of BV-7310, a Proprietary Herbal Formulation of Phyllanthus niruri, Tephrosia purpurea, Boerhavia diffusa, and Andrographis paniculata, in Alcohol-Induced HepG2 Cells and Alcohol plus a Haloalkane, CCl4, Induced Liver Damage in Rats. Evidence-Based Complementary and Alternative Medicine, 2020, 1–9. doi:10.1155/2020/6428906
Shah, P., Singh, S. P., Gupta, A. K., & Kumar, A. (2016). Combined Hepatoprotective Activity of Murraya koenigii and Phyllanthus niruri Extracts Against Paracetamol Induced Hepatotoxicity in Alcoholic Rats. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences, 88(2), 655–665. doi:10.1007/s40011-016-0800-5
Springer Link
Ooi, K. L., Loh, S. I., Sattar, M. A., Muhammad, T. S. T., & Sulaiman, S. F. (2015). Cytotoxic, caspase-3 induction and in vivo hepatoprotective effects of phyllanthin, a major constituent of Phyllanthus niruri. Journal of Functional Foods, 14, 236–243. doi:10.1016/j.jff.2015.01.032
Chinwude, E. I., Roshan, K., Swati, J., Adeola, S. O., & Martins, E. (2014). Identification of sitosteryl glucoside palmitate in a chloroform-derived fraction of Phyllanthus niruri with antiplasmodial and peripheral antinociceptive properties. Asian Pacific Journal of Tropical Biomedicine, 4(9), 707–713. doi:10.12980/apjtb.4.2014apjtb-2013-0025
Scirus- Elsevier
Morán, E., Budía, A., Broseta, E., & Boronat, F. (2013). Phytotherapy in urology. Current scientific evidence of its application in urolithiasis, chronic pelvic pain, erectile dysfunction and urinary tract infections. Actas Urológicas Españolas (English Edition), 37(3), 174–180. https://doi.org/10.1016/j.acuroe.2012.07.016