Phyllanthus niruri

Generalidades

Sinónimos: No aplican.

Nombre común: Iñoncillo, Quebra-pedra, Erva pombinha, Bahupatra, Bhuiamla, Bhuy amalaki, Niruri y Stone Breaker.

Características generales:

  • Es un pequeño arbusto que crece a una altura de 3 a 6 dm, silvestre, anual y de tallo erguido. Sus hojas son de 7 a 12 cm de largo, alternas, sésiles oblongas;

  • Flores pequeñas de color blanquecino-verdoso, solitarias, axilares, apétalas monoicas;

  • Sus frutos de 2 a 3 mm de diámetro, pequeños en una cápsula comprimida y globosa; raíz larga y poco ramificada;

  • Las semillas triangulares y verrucosas.

Usos medicinales reportados

Ampliamente usada en la medicina tradicional para favorecer la expulsión de cálculos renales o biliares, molestias de la vejiga, retención urinaria, diabetes, afecciones del hígado, como diurético.

Usos farmacológicos reportados

  • Contribuye a la eliminación de cálculos renales

  • Ayuda preservar función renal

  • Actividad hepatoprotector

  • Actividad antibacteriana

  • Actividad antidiabética

  • Actividad antitumoral

  • Actividad antiulcerosa

  • Actividad antioxidante

  • Actividad citotóxica

  • Actividad anticancerígena

  • Inducción de apoptosis

  • Inmunomodulación

  • Actividad antiviral

Bibliografías

PubMed

  1. Lee NY, Khoo WK, Adnan MA, Mahalingam TP, Fernandez AR, Jeevaratnam K. The pharmacological potential of Phyllanthus niruri. J Pharm Pharmacol. 2016 Aug;68(8):953-69. doi: 10.1111/jphp.12565. Epub 2016 Jun 10. PMID: 27283048.

  2. Pucci ND, Marchini GS, Mazzucchi E, Reis ST, Srougi M, Evazian D, Nahas WC. Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention. Int Braz J Urol. 2018 Jul-Aug;44(4):758-764. doi: 10.1590/S1677-5538.IBJU.2017.0521. PMID: 29617079; PMCID: PMC6092661.

Google Scholar

  1. Yuniati, Y., Yuliati, L., Monica, E., & Rollando, R. (2019). Discovering anticancer compound of ethyl acetate extract from RL1 code endophytic fungi culture derived by Phyllanthus niruri Linn leaves through cell cycle modulation in T47d cells. IOP Conference Series: Materials Science and Engineering, 509, 012157. doi:10.1088/1757-899x/509/1/012157 

  2. Cao, X., Xing, X., Wei, H., Lu, W., & Wei, W. (2018). Extraction method and anti-cancer evaluation of two lignans from Phyllanthus Niruri L. Medicinal Chemistry Research, 27(8), 2034–2041. doi:10.1007/s00044-018-2212-y 

  3. Putri, D. U., Rintiswati, N., Soesatyo, M. H., & Haryana, S. M. (2017). Immune modulation properties of herbal plant leaves: Phyllanthus niruri aqueous extract on immune cells of tuberculosis patient - in vitro study. Natural Product Research, 32(4), 463–467. doi:10.1080/14786419.2017.1311888 

  4. Navarro, M., Moreira, I., Arnaez, E., Quesada, S., Azofeifa, G., Alvarado, D., & Monagas, M. (2017). Proanthocyanidin Characterization, Antioxidant and Cytotoxic Activities of Three Plants Commonly Used in Traditional Medicine in Costa Rica: Petiveria alliaceae L., Phyllanthus niruri L. and Senna reticulata Willd. Plants, 6(4), 50. doi:10.3390/plants6040050 

  5. Ooi, K. L., Loh, S. I., Sattar, M. A., Muhammad, T. S. T., & Sulaiman, S. F. (2015). Cytotoxic, caspase-3 induction and in vivo hepatoprotective effects of phyllanthin, a major constituent of Phyllanthus niruri. Journal of Functional Foods, 14, 236–243. https://doi.org/10.1016/j.jff.2015.01.032

  6. Ali, H., Dixit, S., Alqahtani, S., Ali, D., Alkahtani, S., & Alarifi, S. (2015). Isolation and evaluation of anticancer efficacy of stigmasterol in a mouse model of DMBA-induced skin carcinoma. Drug Design, Development and Therapy, 2793. https://doi.org/10.2147/dddt.s83514

ScienceDirect

  1. Ooi, K. L., Loh, S. I., Sattar, M. A., Muhammad, T. S. T., & Sulaiman, S. F. (2015). Cytotoxic, caspase-3 induction and in vivo hepatoprotective effects of phyllanthin, a major constituent of Phyllanthus niruri. Journal of Functional Foods, 14, 236–243. doi:10.1016/j.jff.2015.01.032 

  2. Chinwude, E. I., Roshan, K., Swati, J., Adeola, S. O., & Martins, E. (2014). Identification of sitosteryl glucoside palmitate in a chloroform-derived fraction of Phyllanthus niruri with antiplasmodial and peripheral antinociceptive properties. Asian Pacific Journal of Tropical Biomedicine, 4(9), 707–713. doi:10.12980/apjtb.4.2014apjtb-2013-0025 

BioMed Research International

  1. Zheng, Z.-Z., Chen, L.-H., Liu, S.-S., Deng, Y., Zheng, G.-H., Gu, Y., & Ming, Y.-L. (2016). Bioguided Fraction and Isolation of the Antitumor Components fromPhyllanthus niruriL. BioMed Research International, 2016, 1–7. doi:10.1155/2016/9729275 

  2. Dey, D., Chaskar, S., Bhatt, N., & Chitre, D. (2020). Hepatoprotective Activity of BV-7310, a Proprietary Herbal Formulation of Phyllanthus niruri, Tephrosia purpurea, Boerhavia diffusa, and Andrographis paniculata, in Alcohol-Induced HepG2 Cells and Alcohol plus a Haloalkane, CCl4, Induced Liver Damage in Rats. Evidence-Based Complementary and Alternative Medicine, 2020, 1–9. doi:10.1155/2020/6428906 

  3. Shah, P., Singh, S. P., Gupta, A. K., & Kumar, A. (2016). Combined Hepatoprotective Activity of Murraya koenigii and Phyllanthus niruri Extracts Against Paracetamol Induced Hepatotoxicity in Alcoholic Rats. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences, 88(2), 655–665. doi:10.1007/s40011-016-0800-5 

Springer Link

  1. Ooi, K. L., Loh, S. I., Sattar, M. A., Muhammad, T. S. T., & Sulaiman, S. F. (2015). Cytotoxic, caspase-3 induction and in vivo hepatoprotective effects of phyllanthin, a major constituent of Phyllanthus niruri. Journal of Functional Foods, 14, 236–243. doi:10.1016/j.jff.2015.01.032 

  2. Chinwude, E. I., Roshan, K., Swati, J., Adeola, S. O., & Martins, E. (2014). Identification of sitosteryl glucoside palmitate in a chloroform-derived fraction of Phyllanthus niruri with antiplasmodial and peripheral antinociceptive properties. Asian Pacific Journal of Tropical Biomedicine, 4(9), 707–713. doi:10.12980/apjtb.4.2014apjtb-2013-0025 

Scirus- Elsevier

  1. Morán, E., Budía, A., Broseta, E., & Boronat, F. (2013). Phytotherapy in urology. Current scientific evidence of its application in urolithiasis, chronic pelvic pain, erectile dysfunction and urinary tract infections. Actas Urológicas Españolas (English Edition), 37(3), 174–180. https://doi.org/10.1016/j.acuroe.2012.07.016