Elephantopus mollis

Generalidades

Sinónimos:

Nombre común:

Aguatosa, hierba del coyote, rabo de mula (fuera de la zona).

Características generales:

Hierbas perennes, robustas, que alcanzan los 0.3–1.5 m de alto, erectas; ramas pilosas, hirsutas o vellosas. Hojas alternas y/o basales, oblanceoladas, oblongas a obovadas o espatuladas, 7–22 cm de largo y 2–7 cm de ancho, ápice obtuso, agudo o cortamente acuminado, base atenuada y abrazadora.

Usos medicinales reportados.

  • Se utiliza en el tratamiento de diferentes afecciones gastrointestinales.

  • Para el dolor de estómago (dolores pasajeros y poco intensos) Además, se le emplea en casos de estreñimiento.

  • Se usa contra el pie de atleta.

  • Como auxiliar en el tratamiento de diferentes tipos de cáncer.

Usos farmacológicos reportados.

  • Actividad anti proliferativa y apoptótica en cáncer de pulmón, células de leucemia mieloide

  • Actividad citotóxica sobre células cancerosas

  • Actividad antiinflamatoria

  • Inhibidor de la metalogénesis

  • Actividad Leishmanicida

  • Tratamiento de diarrea

  • Actividad hepatoprotectora

Bibliografías

PUBMED

  1. Tabopda TK, Liu J, Ngadjui BT, Luu B. Cytotoxic triterpene and sesquiterpene lactones from Elephantopus mollis and induction of apoptosis in neuroblastoma cells. Planta Med. 2007 Apr;73(4):376-80. doi: 10.1055/s-2007-967132. Epub 2007 Mar 15. PMID: 17366372.

  2. Lee KH, Ibuka T, Huang HC. Letter: Antitumor agents XIV: molephantinin, a new potent antitumor sesquiterpene lactone from Elephantopus mollis. J Pharm Sci. 1975 Jun;64(6):1077-8. doi: 10.1002/jps.2600640656. PMID: 1169316.

  3. Lee KH, Ibuka T, Furukawa H, Kozuka M, Wu RY, Hall IH, Huang HC. Antitumor agents XXXVIII: Isolation and structural elucidation of novel germacranolides and triterpenes from Elephantopus mollis. J Pharm Sci. 1980 Sep;69(9):1050-6. doi: 10.1002/jps.2600690917. PMID: 7411406.

  4. Ooi KL, Tengku Muhammad TS, Lam LY, Sulaiman SF. Cytotoxic and Apoptotic Effects of Ethyl Acetate Extract of Elephantopus mollis Kunth. in Human Liver Carcinoma HepG2 Cells Through Caspase-3 Activation. Integr Cancer Ther. 2014 May;13(3):NP1-9. doi: 10.1177/1534735411433203. Epub 2012 Feb 15. PMID: 22336595.

  5. Liang N, Yang XX, Wang GC, Wu X, Yang YT, Luo HJ, Li YL. [Study on the chemical constituents of Elephantopus mollis]. Zhong Yao Cai. 2012 Nov;35(11):1775-8. Chinese. PMID: 23627086.

  6. Fuchino H, Koide T, Takahashi M, Sekita S, Satake M. New sesquiterpene lactones from Elephantopus mollis and their leishmanicidal activities. Planta Med. 2001 Oct;67(7):647-53. doi: 10.1055/s-2001-17349. PMID: 11582544.

  7. Li H, Li M, Wang G, Shao F, Chen W, Xia C, Wang S, Li Y, Zhou G, Liu Z. EM23, A Natural Sesquiterpene Lactone from Elephantopus mollis, Induces Apoptosis in Human Myeloid Leukemia Cells through Thioredoxin- and Reactive Oxygen Species-Mediated Signaling Pathways. Front Pharmacol. 2016 Mar 29;7:77. doi: 10.3389/fphar.2016.00077. PMID: 27064563; PMCID: PMC4809879.

  8. Ooi KL, Muhammad TS, Tan ML, Sulaiman SF. Cytotoxic, apoptotic and anti-α-glucosidase activities of 3,4-di-O-caffeoyl quinic acid, an antioxidant isolated from the polyphenolic-rich extract of Elephantopus mollis Kunth. J Ethnopharmacol. 2011 Jun 1;135(3):685-95. doi: 10.1016/j.jep.2011.04.001. Epub 2011 Apr 8. PMID: 21497647.

  9. Hasegawa K, Furuya R, Mizuno H, Umishio K, Suetsugu M, Sato K. Inhibitory effect of Elephantopus mollis H.B. and K. extract on melanogenesis in B16 murine melanoma cells by downregulating microphthalmia-associated transcription factor expression. Biosci Biotechnol Biochem. 2010;74(9):1908-12. doi: 10.1271/bbb.100318. Epub 2010 Sep 7. PMID: 20834163.

  10. Kuete V, Fokou FW, Karaosmanoğlu O, Beng VP, Sivas H. Cytotoxicity of the methanol extracts of Elephantopus mollis, Kalanchoe crenata and 4 other Cameroonian medicinal plants towards human carcinoma cells. BMC Complement Altern Med. 2017 May 25;17(1):280. doi: 10.1186/s12906-017-1793-1. PMID: 28545532; PMCID: PMC5445369.

  11. Wu ZN, Zhang YB, Chen NH, Li MJ, Li MM, Tang W, Zhuang L, Li YL, Wang GC. Sesquiterpene lactones from Elephantopus mollis and their anti-inflammatory activities. Phytochemistry. 2017 May;137:81-86. doi: 10.1016/j.phytochem.2017.01.020. Epub 2017 Feb 5. PMID: 28179060.

  12. Bich Ngoc TT, Hoai Nga NT, My Trinh NT, Thuoc TL, Phuong Thao DT. Elephantopus mollis Kunth extracts induce antiproliferation and apoptosis in human lung cancer and myeloid leukemia cells. J Ethnopharmacol. 2020 Dec 5;263:113222. doi: 10.1016/j.jep.2020.113222. Epub 2020 Aug 5. PMID: 32763415.

GOOGLE SCHOOLAR

  1. M. Rifqi, E. (2017, January 11). Isolasi Senyawa AKTIF inhibitor TIROSINASE Dari BEBERAPA Tumbuhan Sumatera (Elephantopus Mollis Kunth., Mangifera indica L., Dan Mussaenda frondosa L.). eSkripsi Universitas Andalas. Retrieved October 13, 2021, from http://scholar.unand.ac.id/22288/.

  2. Additional informationFundingThis work was supported by CONICET [Grant PIP-533] and SCAIT. (n.d.). Trypanocidal activity of South American Vernonieae (asteraceae) extracts and its sesquiterpene lactones. Taylor & Francis. Retrieved October 13, 2021, from https://www.tandfonline.com/doi/full/10.1080/14786419.2020.1739682.

  3. Nguyen, T. H. P., Do, T. K., Nhien, N. T. T., Phan, T. D., & Phung, T. H. (n.d.). Acute toxicity, antibacterial and antioxidant abilities of elephantopus mollis H.B.K. and Elephantopus Scaber L. Can Tho University Journal of Science. Retrieved October 13, 2021, from https://ctujs.ctu.edu.vn/index.php/ctujs/article/view/8.

  4. Francisco, F., Pereira, G. P., Carvalho, R. I. N. de, & Negrelle, R. R. B. (2019, March 28). Maturation, processing and seed storage of elephantopus mollis kunth. Acta Scientiarum. Agronomy. Retrieved October 13, 2021, from https://www.scielo.br/j/asagr/a/xBzKvKsL4r3GgzDXQhGSktn/?lang=en.

  5. Li, H., Li, M., Wang, G., Shao, F., Chen, W., Xia, C., Wang, S., Li, Y., Zhou, G., & Liu, Z. (1AD, January 1). EM23, a natural sesquiterpene lactone from elephantopus mollis, induces apoptosis in human myeloid leukemia cells through thioredoxin- and reactive oxygen species-mediated signaling pathways. Frontiers. Retrieved October 13, 2021, from https://www.frontiersin.org/articles/10.3389/fphar.2016.00077/full.

SCIENCE DIRECT

  1. Chin-Chuan Tsai, Chun-Ching Lin, Anti-inflammatory effects of Taiwan folk medicine ‘Teng-Khia-U’ on carrageenan- and adjuvant-induced paw edema in rats, Journal of Ethnopharmacology, Volume 64, Issue 1, 1998, Pages 85-89, ISSN 0378-8741, https://doi.org/10.1016/S0378-8741(98)00108-1.

  2. Xuan-Minh-Ai Nguyen, Sok-Siya Bun, Evelyne Ollivier, Thi-Phuong-Thao Dang, Ethnobotanical study of medicinal plants used by K’Ho-Cil people for treatment of diarrhea in Lam Dong Province, Vietnam, Journal of Herbal Medicine, Volume 19, 2020, 100320, ISSN 2210-8033, https://doi.org/10.1016/j.hermed.2019.100320.

  3. Kannakuzhiyil Oommen Sheeba, Pallara Janardhanan Wills, Bhaskara Kurup Latha, Rajagopal Rajalekshmy, Mukalel Sankunni Latha, Antioxidant and antihepatotoxic efficacy of methanolic extract of Elephantopus scaber Linn in Wistar rats, Asian Pacific Journal of Tropical Disease, Volume 2, Supplement 2, 2012, Pages S904-S908, ISSN 2222-1808, https://doi.org/10.1016/S2222-1808(12)60289-8.

  4. Anicleto Poli, Mauro Nicolau, Claudia Maria Oliveira Simões, Rosa Maria Ribeiro-do-Valle Nicolau, Marlene Zanin, Preliminary pharmacologic evaluation of crude whole plant extracts of Elephantopus scaber. Part I: in vivo studies, Journal of Ethnopharmacology, Volume 37, Issue 1, 1992, Pages 71-76, ISSN 0378-8741, https://doi.org/10.1016/0378-8741(92)90005-C.

  5. Taizong Wu, Hui Cui, Bao Cheng, Sai Fang, Jun Xu, Qiong Gu, Chemical constituents from the roots of Elephantopus scaber L., Biochemical Systematics and Ecology, Volume 54, 2014, Pages 65-67, ISSN 0305-1978, https://doi.org/10.1016/j.bse.2013.12.012.

  6. Kuo-Hsiung Lee, Toshiro Ibuka, Hiroshi Furukawa, Mutsuo Kozuka, Rong-Yang Wu, Iris H. Hall, Huan-Chang Huang, Antitumor Agents XXXVIII: Isolation and Structural Elucidation of Novel Germacranolides and Triterpenes from Elephantopus mollis, Journal of Pharmaceutical Sciences, Volume 69, Issue 9, 1980, Pages 1050-1056, ISSN 0022-3549, https://doi.org/10.1002/jps.2600690917

  7. Kheng Leong Ooi, Tengku Sifzizul Tengku Muhammad, Mei Lan Tan, Shaida Fariza Sulaiman, Cytotoxic, apoptotic and anti-α-glucosidase activities of 3,4-di-O-caffeoyl quinic acid, an antioxidant isolated from the polyphenolic-rich extract of Elephantopus mollis Kunth., Journal of Ethnopharmacology, Volume 135, Issue 3,

  8. 2011, Pages 685-695, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2011.04.001.

  9. Zhong-Nan Wu, Yu-Bo Zhang, Neng-Hua Chen, Mo-Jiao Li, Man-Mei Li, Wei Tang, Ling Zhuang, Yao-Lan Li, Guo-Cai Wang, Sesquiterpene lactones from Elephantopus mollis and their anti-inflammatory activities, Phytochemistry, Volume 137, 2017, Pages 81-86, ISSN 0031-9422, https://doi.org/10.1016/j.phytochem.2017.01.020.

SPRINGER LINK

  1. Silveira, FS, Azzolini, M. & Divan, AM Escaneo de respuestas fotosintéticas de cadmio de Elephantopus mollis para posibles prácticas de fitorremediación. Agua, aire, suelo, contaminación 226, 359 (2015). https://doi.org/10.1007/s11270-015-2625-x

  2. Kuete, V., Fokou, FW, Karaosmanoğlu, O. et al. Citotoxicidad de los extractos metanólicos de Elephantopus mollis , Kalanchoe crenata y otras 4 plantas medicinales de Camerún hacia células de carcinoma humano. BMC Complement Altern Med 17, 280 (2017). https://doi.org/10.1186/s12906-017-1793-1