Usos medicinales reportados

• Tratamiento de insuficiencia renal.

• Tratamiento de alzhéimer.

• Regulación de hipertiroidismo.

• Tratamiento de cicatrización en personas diabéticas.

• Se ha demostrado que las hojas de Annona muricata tienen efectos antiinflamatorios, antidiabéticos, antiulcerosos y anticancerígenos sobre diferentes tipos de tumores.

Usos farmacológicos reportados

• Actividades biológicas

• Actividad anticancerosa

• Actividad antitumoral

• Actividad hepatoproptectora

• Actividad antioxidante

• Actividad antiulcerosa

• Actividad cicatrizante

• Actividad antixolitis

• Actividad antidiabética

• Potencial antipsoriatico

• Efecto antihepatoma

• Potencial antiurulititico

Bibliografías

PubMed

1. Ma C, Chen Y, Chen J, Li X, Chen Y. A Review on Annona squamosa L.: Phytochemicals and Biological Activities. Am J Chin Med. 2017;45(5):933-964. doi: 10.1142/S0192415X17500501. Epub 2017 Jun 28. PMID: 28659034.

2. Vikas B, Anil S, Remani P. Cytotoxicity Profiling of Annona Squamosa in Cancer Cell Lines. Asian Pac J Cancer Prev. 2019 Sep 1;20(9):2831-2840. doi: 10.31557/APJCP.2019.20.9.2831. PMID: 31554384; PMCID: PMC6976856.

3. Ko GA, Kang HR, Moon JY, Ediriweera MK, Eum S, Bach TT, Cho SK. Annona squamosa L. leaves inhibit alpha-melanocyte-stimulating hormone (α-MSH) stimulated melanogenesis via p38 signaling pathway in B16F10 melanoma cells. J Cosmet Dermatol. 2020 Jul;19(7):1785-1792. doi: 10.1111/jocd.13223. Epub 2019 Nov 25. PMID: 31763737.

4. Fadholly A, Proboningrat A, Dewi Iskandar RP, Rantam FA, Sudjarwo SA. In vitro anticancer activity Annona squamosa extract nanoparticle on WiDr cells. J Adv Pharm Technol Res. 2019 Oct-Dec;10(4):149-154. doi: 10.4103/japtr.JAPTR_10_19. PMID: 31742114; PMCID: PMC6844006.

5. Leite DOD, de F A Nonato C, Camilo CJ, de Carvalho NKG, da Nobrega MGLA, Pereira RC, da Costa JGM. Annona Genus: Traditional Uses, Phytochemistry and Biological Activities. Curr Pharm Des. 2020;26(33):4056-4091. doi: 10.2174/1381612826666200325094422. PMID: 32209036.

6. Ma CY, Lu JH, Li X, Liu X, Chen JW. Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa. Chin J Nat Med. 2019 Apr;17(4):291-297. doi: 10.1016/S1875-5364(19)30032-9. PMID: 31076132.

7. Bhoir SS, Vishwapathi V, Singh KK. Antipsoriatic potential of Annona squamosa seed oil: An in vitro and in vivo evaluation. Phytomedicine. 2019 Feb 15;54:265-277. doi: 10.1016/j.phymed.2018.07.003. Epub 2018 Jul 17. PMID: 30668377.

8. Al-Ghazzawi AM. Anti-cancer activity of new benzyl isoquinoline alkaloid from Saudi plant Annona squamosa. BMC Chem. 2019 Feb 4;13(1):13. doi: 10.1186/s13065-019-0536-4. PMID: 31384762; PMCID: PMC6661725.

9. Chen YY, Li FQ, Zhu XL, Chen JW, Li X. Chemical composition and anti-hepatoma effect of Annona squamosa L. pericarp oil. Nat Prod Res. 2020 May 22:1-4. doi: 10.1080/14786419.2020.1765346. Epub ahead of print. PMID: 32441127.

10. Bonneau N, Baloul L, Bajin Ba Ndob I, Sénéjoux F, Champy P. The fruit of Annona squamosa L. as a source of environmental neurotoxins: From quantification of squamocin to annotation of Annonaceous acetogenins by LC-MS/MS analysis. Food Chem. 2017 Jul 1;226:32-40. doi: 10.1016/j.foodchem.2017.01.042. Epub 2017 Jan 11. PMID: 28254016.

11. Chen Y, Chen Y, Shi Y, Ma C, Wang X, Li Y, Miao Y, Chen J, Li X. Antitumor activity of Annona squamosa seed oil. J Ethnopharmacol. 2016 Dec 4;193:362-367. doi: 10.1016/j.jep.2016.08.036. Epub 2016 Aug 23. PMID: 27566205.

12. Zahid M, Arif M, Rahman MA, Mujahid M. Hepatoprotective and antioxidant activities of Annona squamosa seed extract against alcohol-induced liver injury in Sprague Dawley rats. Drug Chem Toxicol. 2020 Nov;43(6):588-594. doi: 10.1080/01480545.2018.1517772. Epub 2018 Sep 21. PMID: 30239227.

13. Gu S, Sun H, Zhang X, Huang F, Pan L, Zhu Z. Structural characterization and inhibitions on α-glucosidase and α-amylase of alkali-extracted water-soluble polysaccharide from Annona squamosa residue. Int J Biol Macromol. 2021 Jan 1;166:730-740. doi: 10.1016/j.ijbiomac.2020.10.230. Epub 2020 Oct 31. PMID: 33130264.

14. Korah MC, Rahman J, Rajeswari R, Sherief H, Lalitha V, Sengottavelu S, Sivakumar T. Evaluation of diuretic efficacy and antiurolithiatic potential of ethanolic leaf extract of Annona squamosa Linn. in experimental animal models. Indian J Pharmacol. 2020 May-Jun;52(3):196-202. doi: 10.4103/ijp.IJP_92_18. Epub 2020 Aug 4. PMID: 32874002; PMCID: PMC7446677.

15. Pinto NCC, Silva JB, Menegati LM, Guedes MCMR, Marques LB, Silva TPD, Melo RCN, Souza-Fagundes EM, Salvador MJ, Scio E, Fabri RL. Cytotoxicity and bacterial membrane destabilization induced by Annona squamosa L. extracts. An Acad Bras Cienc. 2017;89(3 Suppl):2053-2073. doi: 10.1590/0001-3765201720150702. Epub 2017 Aug 14. PMID: 28813096.

16. Yadav DK, Singh N, Dev K, Sharma R, Sahai M, Palit G, Maurya R. Anti-ulcer constituents of Annona squamosa twigs. Fitoterapia. 2011 Jun;82(4):666-75. doi: 10.1016/j.fitote.2011.02.005. Epub 2011 Feb 20. PMID: 21342663.

17. Ma C, Wang Q, Shi Y, Li Y, Wang X, Li X, Chen Y, Chen J. Three new antitumor annonaceous acetogenins from the seeds of Annona squamosa. Nat Prod Res. 2017 Sep;31(18):2085-2090. doi: 10.1080/14786419.2016.1274897. Epub 2017 Jan 9. PMID: 28064519.

18. Deshmukh AB, Patel JK. Aqueous extract of Annona squamosa (L.) ameliorates renal failure induced by 5/6 nephrectomy in rat. Indian J Pharmacol. 2011 Nov;43(6):718-21. doi: 10.4103/0253-7613.89834. PMID: 22144782; PMCID: PMC3229793.

19. Lim HS, Kim YJ, Sohn E, Yoon J, Kim BY, Jeong SJ. Annona atemoya leaf extract ameliorates cognitive impairment in amyloid-β injected Alzheimer's disease-like mouse model. Exp Biol Med (Maywood). 2019 Dec;244(18):1665-1679. doi: 10.1177/1535370219886269. Epub 2019 Nov 3. PMID: 31679404; PMCID: PMC6963381.

20. Ponrasu T, Suguna L. Efficacy of Annona squamosa L in the synthesis of glycosaminoglycans and collagen during wound repair in streptozotocin induced diabetic rats. Biomed Res Int. 2014;2014:124352. doi: 10.1155/2014/124352. Epub 2014 Jun 9. PMID: 25003104; PMCID: PMC4070582.

21. Panda S, Kar A. Annona squamosa seed extract in the regulation of hyperthyroidism and lipid-peroxidation in mice: possible involvement of quercetin. Phytomedicine. 2007 Dec;14(12):799-805. doi: 10.1016/j.phymed.2006.12.001. Epub 2007 Feb 8. PMID: 17291737.

22. Ren YY, Zhu ZY, Sun HQ, Chen LJ. Structural characterization and inhibition on α-glucosidase activity of acidic polysaccharide from Annona squamosa. Carbohydr Polym. 2017 Oct 15;174:1-12. doi: 10.1016/j.carbpol.2017.05.092. Epub 2017 Jun 15. PMID: 28821021.

23. Ponrasu T, Suguna L. Efficacy of Annona squamosa on wound healing in streptozotocin-induced diabetic rats. Int Wound J. 2012 Dec;9(6):613-23. doi: 10.1111/j.1742-481X.2011.00924.x. Epub 2012 Jan 11. PMID: 22233431; PMCID: PMC7950626.

24. Ansari P, Flatt PR, Harriott P, Abdel-Wahab YHA. Evaluation of the Antidiabetic and Insulin Releasing Effects of A. squamosa, Including Isolation and Characterization of Active Phytochemicals. Plants (Basel). 2020 Oct 12;9(10):1348. doi: 10.3390/plants9101348. PMID: 33053901; PMCID: PMC7601933.

25. Yimam M, Lee YC, Jiao P, Hong M, Brownell L, Jia Q. A Standardized Composition Comprised of Extracts from Rosmarinus officinalis, Annona squamosa and Zanthoxylum clava-herculis for Cellulite. Pharmacognosy Res. 2017 Oct-Dec;9(4):319-324. doi: 10.4103/pr.pr_70_17. PMID: 29263624; PMCID: PMC5717783.

26. Ibrahim RY, Hassan AI, Al-Adham EK. The anti-ulcerative colitis effects of Annona squamosa Linn. leaf aqueous extract in experimental animal model. Int J Clin Exp Med. 2015 Nov 15;8(11):21861-70. PMID: 26885156; PMCID: PMC4724002.

27. Kaleem M, Asif M, Ahmed QU, Bano B. Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Med J. 2006 Aug;47(8):670-5. PMID: 16865205.

28. Kalidindi N, Thimmaiah NV, Jagadeesh NV, Nandeep R, Swetha S, Kalidindi B. Antifungal and antioxidant activities of organic and aqueous extracts of Annona squamosa Linn. leaves. J Food Drug Anal. 2015 Dec;23(4):795-802. doi: 10.1016/j.jfda.2015.04.012. Epub 2015 Jul 26. PMID: 28911497.

Google Scholar

1. Ma, C., Chen, Y., Chen, J., Li, X., & Chen, Y. (2017). A Review on Annona squamosa L.: Phytochemicals and Biological Activities. The American Journal of Chinese Medicine, 45(05), 933–964. doi:10.1142/s0192415x17500501 

2. Kalidindi, N., Thimmaiah, N. V., Jagadeesh, N. V., Nandeep, R., Swetha, S., & Kalidindi, B. (2015). Antifungal and antioxidant activities of organic and aqueous extracts of Annona squamosa Linn. leaves. Journal of Food and Drug Analysis, 23(4), 795–802. doi:10.1016/j.jfda.2015.04.012 

3. Chen, Y., Chen, Y., Shi, Y., Ma, C., Wang, X., Li, Y., … Li, X. (2016). Antitumor activity of Annona squamosa seed oil. Journal of Ethnopharmacology, 193, 362–367. doi:10.1016/j.jep.2016.08.036 

4. Ren, Y., Zhu, Z.-Y., Sun, H., & Chen, L.-J. (2017). Structural characterization and inhibition on α-glucosidase activity of acidic polysaccharide from Annona squamosa. Carbohydrate Polymers, 174, 1–12. doi:10.1016/j.carbpol.2017.05.092 

5. Ruddaraju, L. K., Pallela, P. N. V. K., Pammi, S. V. N., Padavala, V. S., & Kolapalli, V. R. M. (2019). Synergetic antibacterial and anticarcinogenic effects of Annona squamosa leaf extract mediated silver nano particles. Materials Science in Semiconductor Processing, 100, 301–309. doi:10.1016/j.mssp.2019.05.007 

6. Nguyen, M. T., Nguyen, V. T., Le, V. M., Trieu, L. H., Lam, T. D., Bui, L. M., … Danh, V. T. (2020). Assessment of preliminary phytochemical screening, polyphenol content, flavonoid content, and antioxidant activity of custard apple leaves (Annona squamosa Linn.). IOP Conference Series: Materials Science and Engineering, 736, 062012. doi:10.1088/1757-899x/736/6/062012 

7. Pinto, N. C. C., Silva, J. B., Menegati, L. M., Guedes, M. C. M. R., Marques, L. B., Silva, T. P. D., … Fabri, R. L. (2017). Cytotoxicity and bacterial membrane destabilization induced by Annona squamosa L. extracts. Anais Da Academia Brasileira de Ciências, 89(3 suppl), 2053–2073. doi:10.1590/0001-3765201720150702 

8. Ruddaraju, L. K., Pallela, P. N. V. K., Pammi, S. V. N., Padavala, V. S., & Kolapalli, V. R. M. (2019). Synergetic antibacterial and anticarcinogenic effects of Annona squamosa leaf extract mediated silver nano particles. Materials Science in Semiconductor Processing, 100, 301–309. doi:10.1016/j.mssp.2019.05.007 

9. Nguyen, M. T., Nguyen, V. T., Le, V. M., Trieu, L. H., Lam, T. D., Bui, L. M., … Danh, V. T. (2020). Assessment of preliminary phytochemical screening, polyphenol content, flavonoid content, and antioxidant activity of custard apple leaves (Annona squamosa Linn.). IOP Conference Series: Materials Science and Engineering, 736, 062012. doi:10.1088/1757-899x/736/6/062012 

10. Al-ghazzawi, A.M. Anti-cancer activity of new benzyl isoquinoline alkaloid from Saudi plant Annona squamosa. BMC Chemistry 13, 13 (2019). https://doi.org/10.1186/s13065-019-0536-4

11. Miao, Y.-J., Shi, Y.-Y., Li, F.-Q., Shan, C.-X., Chen, Y., Chen, J.-W., & Li, X. (2016). Metabolomics study on the toxicity of Annona squamosa by ultraperformance liquid-chromatography high-definition mass spectrometry coupled with pattern recognition approach and metabolic pathways analysis. Journal of Ethnopharmacology, 184, 187–195. doi:10.1016/j.jep.2016.03.006 

12. Zahid, M., Arif, M., Rahman, M. A., & Mujahid, M. (2018). Hepatoprotective and antioxidant activities of Annona squamosa seed extract against alcohol-induced liver injury in Sprague Dawley rats. Drug and Chemical Toxicology, 1–7. doi:10.1080/01480545.2018.1517772 

13. Salman, Hamzah. (2015). Antibacterial activity of annona squamosa l. And annona reticulata l. against clinical isolates of mutans streptococci the causative agents of dental caries. Asian Journal of Pharmaceutical and Clinical Research. 8. 152-155.

14. Chen, Y., Cao, Y., Li, F., Zhu, X., Peng, C., Lu, J., … Chen, Y. (2017). Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. Bioorganic & Medicinal Chemistry Letters, 27(9), 1907–1910. doi:10.1016/j.bmcl.2017.03.036 

15. Senadeera, S. S., Prasanna, P. H. P., Jayawardana, N. W. I. A., Gunasekara, D. C. S., Senadeera, P., & Chandrasekara, A. (2018). Antioxidant, physicochemical, microbiological, and sensory properties of probiotic yoghurt incorporated with various Annona species pulp. Heliyon, 4(11), e00955. doi:10.1016/j.heliyon.2018.e00955 

ScienceDirect

1. Gu, S., Sun, H., Zhang, X., Huang, F., Pan, L., & Zhu, Z. (2021). Structural characterization and inhibitions on α-glucosidase and α-amylase of alkali-extracted water-soluble polysaccharide from Annona squamosa residue. International Journal of Biological Macromolecules, 166, 730–740. doi:10.1016/j.ijbiomac.2020.10.230 

2. MA, C.-Y., LU, J.-H., LI, X., LIU, X., & CHEN, J.-W. (2019). Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa. Chinese Journal of Natural Medicines, 17(4), 291–297. doi:10.1016/s1875-5364(19)30032-9 

3. Chen, Y., Cao, Y., Li, F., Zhu, X., Peng, C., Lu, J., … Chen, Y. (2017). Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. Bioorganic & Medicinal Chemistry Letters, 27(9), 1907–1910. doi:10.1016/j.bmcl.2017.03.036 

4. Dikti Vildina, J., Ndjonka, D., Schmidt, T. J., & Liebau, E. (2021). Identification of anti-Caenorhabditis and anti-Onchocerca constituents from leaves of Annona senegalensis Pers. (Annonaceae). South African Journal of Botany, 138, 84–93. doi:10.1016/j.sajb.2020.12.019 

5. Quílez, A. M., Fernández-Arche, M. A., García-Giménez, M. D., & De la Puerta, R. (2018). Potential therapeutic applications of the genus Annona : Local and traditional uses and pharmacology. Journal of Ethnopharmacology, 225, 244–270. doi:10.1016/j.jep.2018.06.014 

6. Monteiro, Á. B., Kelly de Souza Rodrigues, C., Petícia do Nascimento, E., Sales, V. dos S., de Araújo Delmondes, G., Nogueira da Costa, M. H., … Kerntopf, M. R. (2019). Anxiolytic and antidepressant-like effects of Annona coriacea (Mart.) and caffeic acid in mice. Food and Chemical Toxicology, 111049. doi:10.1016/j.fct.2019.111049 

7. Mazumdar, S., Ghosh, A. K., Dinda, M., Das, A. K., Das, S., Jana, K., & Karmakar, P. (2019). Evaluation of wound healing activity of ethanol extract of Annona reticulata L. leaf both in vitro and in diabetic mice model. Journal of Traditional and Complementary Medicine. doi:10.1016/j.jtcme.2019.12.001 

8. Dikti Vildina, J., Ndjonka, D., Schmidt, T. J., & Liebau, E. (2021). Identification of anti-Caenorhabditis and anti-Onchocerca constituents from leaves of Annona senegalensis Pers. (Annonaceae). South African Journal of Botany, 138, 84–93. doi:10.1016/j.sajb.2020.12.019 

9. Bento, E. B., Júnior, F. E. de B., de Oliveira, D. R., Fernandes, C. N., de Araújo Delmondes, G., Cesário, F. R. A. S., … Kerntopf, M. R. (2018). Antiulcerogenic activity of the hydroalcoholic extract of leaves of Annona muricata Linnaeus in mice. Saudi Journal of Biological Sciences, 25(4), 609–621. doi:10.1016/j.sjbs.2016.01.024 

BioMed Research International

1. Rady, I., Bloch, M. B., Chamcheu, R.-C. N., Banang Mbeumi, S., Anwar, M. R., Mohamed, H., … Chamcheu, J. C. (2018). Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review. Oxidative Medicine and Cellular Longevity, 2018, 1–39. doi:10.1155/2018/1826170 

2. Rubio-Melgarejo, A., Balois-Morales, R., Palomino-Hermosillo, Y. A., López-Guzmán, G. G., Ramírez-Ramírez, J. C., Cervantes-García, E., … Bautista-Rosales, P. U. (2020). Phytochemical and Antioxidant Dynamics of the Soursop Fruit (Annona muricata L.) in response to Colletotrichum spp. Journal of Food Quality, 2020, 1–12. doi:10.1155/2020/3180634 

3. Elagbar, Z. A., Naik, R. R., Shakya, A. K., & Bardaweel, S. K. (2016). Fatty Acids Analysis, Antioxidant and Biological Activity of Fixed Oil ofAnnona muricataL. Seeds. Journal of Chemistry, 2016, 1–6. doi:10.1155/2016/6948098 

4. Iyanda-Joel, W. O., Ajetunmobi, O. B., Chinedu, S. N., Iweala, E. E. J., & Adegbite, O. S. (2019). Phytochemical, Antioxidant and Mitochondrial Permeability Transition Studies on Fruit-Skin Ethanol Extract of Annona muricata. Journal of Toxicology, 2019, 1–9. doi:10.1155/2019/7607031 

5. Rady, I., Bloch, M. B., Chamcheu, R.-C. N., Banang Mbeumi, S., Anwar, M. R., Mohamed, H., … Chamcheu, J. C. (2018). Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review. Oxidative Medicine and Cellular Longevity, 2018, 1–39. doi:10.1155/2018/1826170 

6. Brindis, F., González-Trujano, M. E., González-Andrade, M., Aguirre-Hernández, E., & Villalobos-Molina, R. (2013). Aqueous Extract ofAnnona macroprophyllata: A Potentialα-Glucosidase Inhibitor. BioMed Research International, 2013, 1–6. doi:10.1155/2013/591313 

7. Elagbar, Z. A., Naik, R. R., Shakya, A. K., & Bardaweel, S. K. (2016). Fatty Acids Analysis, Antioxidant and Biological Activity of Fixed Oil ofAnnona muricataL. Seeds. Journal of Chemistry, 2016, 1–6. doi:10.1155/2016/6948098 

8. Sokpe, A., Mensah, M. L. K., Koffuor, G. A., Thomford, K. P., Arthur, R., Jibira, Y., … Agbemenyah, H. Y. (2020). Hypotensive and Antihypertensive Properties and Safety for Use of Annona muricata and Persea americana and Their Combination Products. Evidence-Based Complementary and Alternative Medicine, 2020, 1–13. doi:10.1155/2020/8833828 

9. Somsak, V., Polwiang, N., & Chachiyo, S. (2016). In VivoAntimalarial Activity ofAnnona muricataLeaf Extract in Mice Infected withPlasmodium berghei. Journal of Pathogens, 2016, 1–5. doi:10.1155/2016/3264070 

10. Abdullah, M., Syam, A. F., Meilany, S., Laksono, B., Prabu, O. G., Bekti, H. S., … Makmun, D. (2017). The Value of Caspase-3 after the Application of Annona muricata Leaf Extract in COLO-205 Colorectal Cancer Cell Line. Gastroenterology Research and Practice, 2017, 1–5. doi:10.1155/2017/4357165 

11. Gyesi, J. N., Opoku, R., & Borquaye, L. S. (2019). Chemical Composition, Total Phenolic Content, and Antioxidant Activities of the Essential Oils of the Leaves and Fruit Pulp of Annona muricata L. (Soursop) from Ghana. Biochemistry Research International, 2019, 1–9. doi:10.1155/2019/4164576 

12. Kim, J. Y., Dao, T. T. P., Song, K., Park, S. B., Jang, H., Park, M. K., … Kim, Y. S. (2018). Annona muricata Leaf Extract Triggered Intrinsic Apoptotic Pathway to Attenuate Cancerous Features of Triple Negative Breast Cancer MDA-MB-231 Cells. Evidence-Based Complementary and Alternative Medicine, 2018, 1–10. doi:10.1155/2018/7972916 

Springer Link

1. Sreevidya, M., Gopalakrishnan, S., Kudapa, H., & Varshney, R. K. (2016). Exploring plant growth-promotion actinomycetes from vermicompost and rhizosphere soil for yield enhancement in chickpea. Brazilian Journal of Microbiology, 47(1), 85–95. doi:10.1016/j.bjm.2015.11.030 

Scirus- Elsevier

1. Shaniba, V.S., Aziz, A.A., Joseph, J. et al. Synthesis, Characterization and Evaluation of Antioxidant and Cytotoxic Potential of Annona muricata Root Extract-derived Biogenic Silver Nanoparticles. J Clust Sci (2021). https://doi.org/10.1007/s10876-021-01981-1

2. Neelima, S., Dwarakanadha Reddy, P. & Kothapalli Bannoth, C.S. Nephroprotective activity of Annona Squamosa leaves against paracetamol-induced nephrotoxicity in rats: in vitro and in vivo experiments. Futur J Pharm Sci 6, 131 (2020). https://doi.org/10.1186/s43094-020-00149-4

3. Younes, M., Ammoury, C., Haykal, T. et al. The selective anti-proliferative and pro-apoptotic effect of A. cherimola on MDA-MB-231 breast cancer cell line. BMC Complement Med Ther 20, 343 (2020). https://doi.org/10.1186/s12906-020-03120-1

4. Brígido, H.P.C., Correa-Barbosa, J., da Silva-Silva, J.V. et al. Antileishmanial activity of Annona species (Annonaceae). SN Appl. Sci. 2, 1524 (2020). https://doi.org/10.1007/s42452-020-03340-7

5. Kumari M.S., Ammani K. (2020) Ethnobotany of Medicinal Plants of Eastern Ghats of Andhra Pradesh for the Identification of Plants with Antitumour and Antimicrobial Potential. In: Khasim S.M., Long C., Thammasiri K., Lutken H. (eds) Medicinal Plants: Biodiversity, Sustainable Utilization and Conservation. Springer, Singapore. https://doi.org/10.1007/978-981-15-1636-8_15