Plumeria rubra

Generalidades

Sinónimos: No aplican.

Nombre común: Cacalosúchil, decó, deká, dexé(otomí) (zona de estudio). Cundá, franquipani, parandechicua (purépecha), uculhuitz (huasteco) (fuera de la zona).

Características generales:

  • Forma de árbol o arbusto caducifolio, de 5 a 8 m (hasta 25 m) de altur con un diámetro a la altura del pecho de hasta 70 cm, con abundante líquido lechoso en la corteza.

  • Copa irregular, abierta. Hojas simples dispuestas en espiral, aglomeradas en las puntas de las ramas; láminas de 15 a 30 cm de largo por 4 a 8 cm de ancho, oblanceoladas o elípticas, margen entero; verde brillantes en el haz y verde pálidas en el envés.

  • Tronco derecho, con pocas ramas gruesas y torcidas. Ramificación di o tricótoma. Las ramas poseen una terminación roma lo que le da un aspecto característico.

  • Corteza externa lisa, brillante a escamosa en piezas papiráceas, con abundantes lenticelas suberificadas y protuberantes, gris plomiza y verde en los sitios recién descamados. Interna de color crema amarillento, granulosa, sabor picante, abundante exudado blanco.

  • Flor(es) en panículas densas en las axilas de hojas nuevas, de 15 a 35 cm, glabras; flores muy fragantes, actinomórficas; sépalos pardo verdosos; corola blanca pura y ligeramente amarilla en el cuello. Las plantas cultivadas producen flores de color amarillo o gamas que van de rosado a púrpura con interesantes combinaciones.

  • Fruto(s) como folículos (vainas) de 25 a 30 cm de largo y 3 cm de diámetro, geminados, péndulos, verde amarillentos o verde anaranjados, glabros, con numerosas semillas.

  • Semillas aladas hasta de 6.5 cm, incluyendo el ala, de color pardo oscuras.

Usos medicinales reportados

  • Tratamiento de la malaria.

  • Toda la planta contiene alcaloides que actúan como estimulantes cardíacos pero no han sido bien estudiados.

  • La infusión de la corteza se emplea para curar contusiones internas.

  • El jugo se usa para curar heridas.

  • Planta: Favorece la producción de leche (galactógeno), y es remedio contra la erisipela.

  • El jugo cáustico lechoso que emana del tronco es venenoso.

Usos farmacológicos reportados

  • Efectos ansiolíticos

  • Actividad larvicida

  • Actividad abortiva

  • Actividad antimicrobiana

  • Actividad antidiarreica

  • Actividad antiinflamatoria


Bibliografías

PubMed

  1. Bihani T. Plumeria rubra L.- A review on its ethnopharmacological, morphological, phytochemical, pharmacological and toxicological studies. J Ethnopharmacol. 2021 Jan 10;264:113291. doi: 10.1016/j.jep.2020.113291. Epub 2020 Aug 22. PMID: 32841700.

  2. Zhang SN, Song HZ, Ma RJ, Liang CQ, Wang HS, Tan QG. Potential anti-diabetic isoprenoids and a long-chain δ-lactone from frangipani (Plumeria rubra). Fitoterapia. 2020 Oct;146:104684. doi: 10.1016/j.fitote.2020.104684. Epub 2020 Jul 4. PMID: 32634455.

  3. Freitas CDT, Nishi BC, do Nascimento CTM, Silva MZR, Bezerra EHS, Rocha BAM, Grangeiro TB, Oliveira JPB, Souza PFN, Ramos MV. Characterization of Three Osmotin-Like Proteins from Plumeria rubra and Prospection for Adiponectin Peptidomimetics. Protein Pept Lett. 2020;27(7):593-603. doi: 10.2174/0929866527666200129154357. PMID: 31994998.

  4. Mohamed Isa SSP, Ablat A, Mohamad J. The Antioxidant and Xanthine Oxidase Inhibitory Activity of Plumeria rubra Flowers. Molecules. 2018 Feb 13;23(2):400. doi: 10.3390/molecules23020400. PMID: 29438299; PMCID: PMC6017381.

  5. Chatterjee M, Verma R, Lakshmi V, Sengupta S, Verma AK, Mahdi AA, Palit G. Anxiolytic effects of Plumeria rubra var. acutifolia (Poiret) L. flower extracts in the elevated plus-maze model of anxiety in mice. Asian J Psychiatr. 2013 Apr;6(2):113-8. doi: 10.1016/j.ajp.2012.09.005. Epub 2012 Nov 3. PMID: 23466106.

  6. Shi YH, Sun W, Fang GH, Zheng RB, Xu WL, Huang XD, Weng SQ, Li CY, Chen SL. [Identification of herbal tea ingredient Plumeria rubra and its adulterants using DNA barcoding]. Zhongguo Zhong Yao Za Zhi. 2014 Jun;39(12):2199-203. Chinese. PMID: 25244744.

  7. Holcomb GE, Aime MC. First Report of Plumeria spp. Rust Caused by Coleosporium plumeriae in Louisiana and Malaysia and Catheranthus roseus, a New Host of this Rust. Plant Dis. 2010 Feb;94(2):272. doi: 10.1094/PDIS-94-2-0272C. PMID: 30754293.

  8. Kardono LB, Tsauri S, Padmawinata K, Pezzuto JM, Kinghorn AD. Cytotoxic constituents of the bark of Plumeria rubra collected in Indonesia. J Nat Prod. 1990 Nov-Dec;53(6):1447-55. doi: 10.1021/np50072a008. PMID: 1965200.

  9. Viana CA, Oliveira JS, Freitas CD, Alencar NM, Carvalho CP, Nishi BC, Ramos MV. Thrombin and plasmin-like activities in the latices of Cryptostegia grandiflora and Plumeria rubra. Blood Coagul Fibrinolysis. 2013 Jun;24(4):386-92. doi: 10.1097/MBC.0b013e32835d540b. PMID: 23314383.

  10. de Alencar NM, Pinheiro RS, de Figueiredo IS, Luz PB, Freitas LB, de Souza Tde F, do Carmo LD, Marques LM, Ramos MV. The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal Plant Plumeria rubra: Involvement of the Latex Proteins in the NO/cGMP/K ATP Signaling Pathway. Evid Based Complement Alternat Med. 2015;2015:706782. doi: 10.1155/2015/706782. Epub 2015 Dec 14. PMID: 26788111; PMCID: PMC4691623.

  11. Patil CD, Patil SV, Borase HP, Salunke BK, Salunkhe RB. Larvicidal activity of silver nanoparticles synthesized using Plumeria rubra plant latex against Aedes aegypti and Anopheles stephensi. Parasitol Res. 2012 May;110(5):1815-22. doi: 10.1007/s00436-011-2704-x. Epub 2011 Nov 18. PMID: 22089086.

  12. Dabhadkar D, Zade V. Abortifacient activity of Plumeria rubra (Linn) pod extract in female albino rats. Indian J Exp Biol. 2012 Oct;50(10):702-7. PMID: 23214263.

  13. Kuigoua GM, Kouam SF, Ngadjui BT, Schulz B, Green IR, Choudhary MI, Krohn K. Minor secondary metabolic products from the stem bark of Plumeria rubra Linn. displaying antimicrobial activities. Planta Med. 2010 Apr;76(6):620-5. doi: 10.1055/s-0029-1240611. Epub 2009 Nov 20. PMID: 19937550.

  14. Ahmed AS, Ahmed Q, Saxena AK, Jamal P. Evaluation of in vitro antidiabetic and antioxidant characterizations of Elettaria cardamomum (L.) Maton (Zingiberaceae), Piper cubeba L. f. (Piperaceae), and Plumeria rubra L. (Apocynaceae). Pak J Pharm Sci. 2017 Jan;30(1):113-126. PMID: 28603121.

  15. Cambon E, Gouzou F, Pina M, Barea B, Barouh N, Lago R, Ruales J, Tsai SW, Villeneuve P. Comparison of the lipase activity in hydrolysis and acyl transfer reactions of two latex plant extracts from babaco (Vasconcellea x Heilbornii Cv.) and Plumeria rubra: Effect of the Aqueous microenvironment. J Agric Food Chem. 2006 Apr 5;54(7):2726-31. doi: 10.1021/jf052505k. PMID: 16569067.

  16. Ye G, Yang YL, Xia GX, Fan MS, Huang CG. Complete NMR spectral assignments of two new iridoid diastereoisomers from the flowers of Plumeria rubra L. cv. acutifolia. Magn Reson Chem. 2008 Dec;46(12):1195-7. doi: 10.1002/mrc.2331. PMID: 18802971.

  17. Ramos MV, Pereira DA, Souza DP, Silva ML, Alencar LM, Sousa JS, Queiroz JF, Freitas CD. Peptidases and peptidase inhibitors in gut of caterpillars and in the latex of their host plants. Planta. 2015 Jan;241(1):167-78. doi: 10.1007/s00425-014-2174-3. Epub 2014 Sep 23. PMID: 25246317.

  18. Kuete V, Efferth T. Pharmacogenomics of Cameroonian traditional herbal medicine for cancer therapy. J Ethnopharmacol. 2011 Sep 1;137(1):752-66. doi: 10.1016/j.jep.2011.06.035. Epub 2011 Jul 6. PMID: 21763411.

  19. Souza DP, Freitas CD, Pereira DA, Nogueira FC, Silva FD, Salas CE, Ramos MV. Laticifer proteins play a defensive role against hemibiotrophic and necrotrophic phytopathogens. Planta. 2011 Jul;234(1):183-93. doi: 10.1007/s00425-011-1392-1. Epub 2011 Mar 11. PMID: 21394468.

  20. Gaitán I, Paz AM, Zacchino SA, Tamayo G, Giménez A, Pinzón R, Cáceres A, Gupta MP. Subcutaneous antifungal screening of Latin American plant extracts against Sporothrix schenckii and Fonsecaea pedrosoi. Pharm Biol. 2011 Sep;49(9):907-19. doi: 10.3109/13880209.2011.555916. Epub 2011 May 19. PMID: 21592008.

Google Scholar

  1. Bihani, T. (2020). L– A review on its ethnopharmacological, morphological, phytochemical, pharmacological and toxicological studies. Journal of Ethnopharmacology, 113291. doi:10.1016/j.jep.2020.113291 

  2. Mohamed Isa SSP, Ablat A, Mohamad J. The Antioxidant and Xanthine Oxidase Inhibitory Activity of Plumeria rubra Flowers. Molecules. 2018; 23(2):400. https://doi.org/10.3390/molecules23020400

  3. Zhang, S.-N., Song, H.-Z., Ma, R.-J., Liang, C.-Q., Wang, H.-S., & Tan, Q.-G. (2020). Potential anti-diabetic isoprenoids and a long-chain δ-lactone from frangipani (Plumeria rubra). Fitoterapia, 104684. doi:10.1016/j.fitote.2020.104684 

  4. Muruganantham, N., S. Solomon and M. M. Senthamilselvi. “Anti-oxidant and Anti-inflammatory activity of Plumeria rubra ( Flowers ) A Research.” (2015).

  5. Katsayal, U., Abubakar, M., Ahmed, A. and Abdurahman, E. (2015) “Perceptions of the Traditional Medical Practitioners of North-Western Nigeria on Malaria Treatment and the Potential Antiplasmodial Properties of Plumeria rubra Stem-Bark”, Journal of Pharmaceutical Research International, 6(3), pp. 191-202. doi: 10.9734/BJPR/2015/16072.

  6. Pasaribu, T., Tobing, R. D. D. M., Kostaman, T., & Dewantoro, B. (2020). Active substance compounds and antibacterial activity of extract flower and leaves of Plumeria rubra and Plumeria alba against Escherichia coli. INTERNATIONAL CONFERENCE ON SCIENCE AND APPLIED SCIENCE (ICSAS2020). doi:10.1063/5.0030472 

  7. Razak N.I.A., Hassan S.S.S., Nasir N.A.H.A. (2020) Ethnobotanical Study on Flowering Plants Along with Phytochemicals and Antioxidants Analysis on Selected Plumeria Species. In: Alias N., Yusof R. (eds) Charting the Sustainable Future of ASEAN in Science and Technology. Springer, Singapore. https://doi.org/10.1007/978-981-15-3434-8_20

  8. Santana, L. de A. B., Aragão, D. P., Araújo, T. de S. L., Sousa, N. A. de, Souza, L. K. M. de, Oliveira, L. E. S., … Oliveira, J. S. de. (2018). Antidiarrheal effects of water-soluble proteins from Plumeria pudica latex in mice. Biomedicine & Pharmacotherapy, 97, 1147–1154. doi:10.1016/j.biopha.2017.11.019 

ScienceDirect

  1. Zhang, S.-N., Song, H.-Z., Ma, R.-J., Liang, C.-Q., Wang, H.-S., & Tan, Q.-G. (2020). Potential anti-diabetic isoprenoids and a long-chain δ-lactone from frangipani (Plumeria rubra). Fitoterapia, 104684. doi:10.1016/j.fitote.2020.104684 

  2. Bihani, T. (2020). L– A review on its ethnopharmacological, morphological, phytochemical, pharmacological and toxicological studies. Journal of Ethnopharmacology, 113291. doi:10.1016/j.jep.2020.113291 

  3. Bihani, T., Bura, A., & Mhaske, N. (2019). Evaluation of In Vivo Wound Healing Activity of Plumeria obtusa L. (Champa) Spray in Rats. Wound Medicine, 100176. doi:10.1016/j.wndm.2019.100176 

BioMed Research International

  1. Xie, P., Cui, L., Shan, Y., & Kang, W. (2017). Antithrombotic Effect and Mechanism of Radix Paeoniae Rubra. BioMed Research International, 2017, 1–9. doi:10.1155/2017/9475074 

  2. Chang, C.-C., Yuan, W., Lin, Y.-L., Liu, R.-S., Juan, Y.-C., Sun, W.-H., … Liu, H.-K. (2016). Evaluation of theIn VivoTherapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays. Evidence-Based Complementary and Alternative Medicine, 2016, 1–11. doi:10.1155/2016/3262790 

Springer Link

  1. Fernandes, H.B., Machado, D.L., Dias, J.M. et al. Laticifer proteins from Plumeria pudica inhibit the inflammatory and nociceptive responses by decreasing the action of inflammatory mediators and pro-inflammatory cytokines. Rev. Bras. Farmacogn. 25, 269–277 (2015). https://doi.org/10.1016/j.bjp.2015.05.003

  2. Ramos, M.V., Pereira, D.A., Souza, D.P. et al. Peptidases and peptidase inhibitors in gut of caterpillars and in the latex of their host plants. Planta 241, 167–178 (2015). https://doi.org/10.1007/s00425-014-2174-3

  3. Jabborova D., Davranov K., Egamberdieva D. (2019) Antibacterial, Antifungal, and Antiviral Properties of Medical Plants. In: Egamberdieva D., Tiezzi A. (eds) Medically Important Plant Biomes: Source of Secondary Metabolites. Microorganisms for Sustainability, vol 15. Springer, Singapore. https://doi.org/10.1007/978-981-13-9566-6_3