Tabernaemontana alba
Generalidades
Sinónimos: No aplican.
Nombre común: Huevo de gato (en la zona). Cojón de gato, lecherillo, palo de San Diego, t'abat (huasteco) (fuera de la zona).
Características generales:
Tabernaemontana es un género con 100-110 especies de plantas de flores pertenecientes a la familia Apocynaceae, con una distribución tropical.
Son arbustos y pequeños árboles que alcanza 1-15 metros de altura.
Las hojas son perennes opuestas de 3-25 cm de longitud.
Las flores son olorosas, blancas de 1-5 cm de diámetro, sépalos pequeños más o menos iguales; corola hipocrateriforme; anteras no aglutinadas a la cabeza del estilo; ovario apocárpico.
Son arbustos o árboles con látex blanco y ramas bifurcadas.
Hojas opuestas, eglandulares. Inflorescencia cimoso-paniculada,
Fruto de 2 folículos cortos, carnosos, dehiscentes y exhibiendo las numerosas semillas con conspicuo arilo anaranjado.
Usos medicinales reportados
La decocción de la raíz se usa oralmente para tratar malaria, mordeduras de culebra, dolor de estómago, bajar la presión arterial, como depurador y febrífugo.
A la hoja, tallo, corteza y raíz se les atribuye propiedad febrífuga, antimalárica, antihipertensiva y sedante.
Usos farmacológicos reportados
Actividad antimicrobiana
Actividad antioxidante
Actividad antitumoral
Actividad citotóxica
Actividad antitumoral
Actividad antimicrobiana
Actividad anticancerígena
Actividad analgésica
Actividad antihelmíntica
Potencial anti-neuraminidasa
Bibliografías
PubMed
Guzmán-Gutiérrez SL, Silva-Miranda M, Krengel F, Huerta-Salazar E, León-Santiago M, Díaz-Cantón JK, Espitia Pinzón C, Reyes-Chilpa R. Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea. Planta Med. 2020 May 11. doi: 10.1055/a-1157-1732. Epub ahead of print. Erratum in: Planta Med. 2020 May 18;: PMID: 32392600.
Guzmán-Gutiérrez SL, Silva-Miranda M, Krengel F, Huerta-Salazar E, León-Santiago M, Díaz-Cantón JK, Espitia Pinzón C, Reyes-Chilpa R. Erratum: Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea. Planta Med. 2020 May 18. doi: 10.1055/a-1177-3691. Epub ahead of print. Erratum for: Planta Med. 2020 May 11;: PMID: 32422666.
Krengel F, Mijangos MV, Reyes-Lezama M, Reyes-Chilpa R. Extraction and Conversion Studies of the Antiaddictive Alkaloids Coronaridine, Ibogamine, Voacangine, and Ibogaine from Two Mexican Tabernaemontana Species (Apocynaceae). Chem Biodivers. 2019 Jul;16(7):e1900175. doi: 10.1002/cbdv.201900175. Epub 2019 Jun 13. PMID: 31095891.
Krengel F, Herrera Santoyo J, Olivera Flores TJ, Chávez Ávila VM, Pérez Flores FJ, Reyes Chilpa R. Quantification of Anti-Addictive Alkaloids Ibogaine and Voacangine in In Vivo- and In Vitro-Grown Plants of Two Mexican Tabernaemontana Species. Chem Biodivers. 2016 Dec;13(12):1730-1737. doi: 10.1002/cbdv.201600146. Epub 2016 Nov 17. PMID: 27448833.
Google Scholar
Guzmán-Gutiérrez, S. L., Silva-Miranda, M., Krengel, F., Huerta-Salazar, E., León-Santiago, M., Díaz-Cantón, J. K., … Reyes-Chilpa, R. (2020). Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea. Planta Medica. doi:10.1055/a-1157-1732
Krengel, F., Chevalier, Q., Dickinson, J., Santoyo, J. H., & Reyes-Chilpa, R. (2019). Metabolite Profiling of Antiaddictive Alkaloids from Four Mexican Tabernaemontana Species and the Entheogenic African Shrub Tabernanthe iboga (Apocynaceae). Chemistry & Biodiversity. doi:10.1002/cbdv.201800506
Shi, B.-B., Chen, J., Bao, M.-F., Zeng, Y., & Cai, X.-H. (2019). Alkaloids isolated from Tabernaemontana bufalina display xanthine oxidase inhibitory activity. Phytochemistry, 166, 112060. doi:10.1016/j.phytochem.2019.112060
Canaveze, Y., & Machado, S. R. (2016). The Occurrence of Intrusive Growth Associated with Articulated Laticifers in Tabernaemontana catharinensis A.DC., a New Record for Apocynaceae. International Journal of Plant Sciences, 177(5), 458–467. doi:10.1086/685446
ScienceDirect
Silveira, D., de Melo, A. M. M. F., Magalhães, P. O., & Fonseca-Bazzo, Y. M. (2017). Tabernaemontana Species: Promising Sources of New Useful Drugs. Studies in Natural Products Chemistry, 227–289. doi:10.1016/b978-0-444-63929-5.00007-3
Hernández-Castro, C., Diaz-Castillo, F., & Martínez-Gutierrez, M. (2015). Ethanol extracts of Cassia grandis and Tabernaemontana cymosa inhibit the in vitro replication of dengue virus serotype 2. Asian Pacific Journal of Tropical Disease, 5(2), 98–106. doi:10.1016/s2222-1808(14)60635-6
BioMed Research International
Khan, W., Subhan, S., Shams, D. F., Afridi, S. G., Ullah, R., Shahat, A. A., & Alqahtani, A. S. (2019). Antioxidant Potential, Phytochemicals Composition, and Metal Contents of Datura alba. BioMed Research International, 2019, 1–8. doi:10.1155/2019/2403718
De Oliveira, A. M., Mesquita, M. da S., da Silva, G. C., de Oliveira Lima, E., de Medeiros, P. L., Paiva, P. M. G., … Napoleão, T. H. (2015). Evaluation of Toxicity and Antimicrobial Activity of an Ethanolic Extract from Leaves of Morus alba L. (Moraceae). Evidence-Based Complementary and Alternative Medicine, 2015, 1–7. doi:10.1155/2015/513978
Kim, H., & Chung, M. S. (2018). Antiviral Activities of Mulberry (Morus alba) Juice and Seed against Influenza Viruses. Evidence-Based Complementary and Alternative Medicine, 2018, 1–10. doi:10.1155/2018/2606583
Baskaran, G., Salvamani, S., Azlan, A., Ahmad, S. A., Yeap, S. K., & Shukor, M. Y. (2015). Hypocholesterolemic and Antiatherosclerotic Potential ofBasella albaLeaf Extract in Hypercholesterolemia-Induced Rabbits. Evidence-Based Complementary and Alternative Medicine, 2015, 1–7. doi:10.1155/2015/751714
Su-Hong, C., Qi, C., Bo, L., Jian-Li, G., Jie, S., & Gui-Yuan, L. (2015). Antihypertensive Effect of Radix Paeoniae Alba in Spontaneously Hypertensive Rats and Excessive Alcohol Intake and High Fat Diet Induced Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine, 2015, 1–8. doi:10.1155/2015/731237
Soonthornsit, N., Pitaksutheepong, C., Hemstapat, W., Utaisincharoen, P., & Pitaksuteepong, T. (2017). In Vitro Anti-Inflammatory Activity of Morus alba L. Stem Extract in LPS-Stimulated RAW 264.7 Cells. Evidence-Based Complementary and Alternative Medicine, 2017, 1–8. doi:10.1155/2017/3928956
Islam, M. S., Rahi, M. S., Jahangir, C. A., Rahman, M. H., Jerin, I., Amin, R., … Reza, M. A. (2018). In Vivo Anticancer Activity of Basella alba Leaf and Seed Extracts against Ehrlich’s Ascites Carcinoma (EAC) Cell Line. Evidence-Based Complementary and Alternative Medicine, 2018, 1–11. doi:10.1155/2018/1537896
Kalman, D. S., & Hewlings, S. J. (2017). The Effects of Morus alba and Acacia catechu on Quality of Life and Overall Function in Adults with Osteoarthritis of the Knee. Journal of Nutrition and Metabolism, 2017, 1–9. doi:10.1155/2017/4893104
Ahmed, A. H., Ejo, M., Feyera, T., Regassa, D., Mummed, B., & Huluka, S. A. (2020). In Vitro Anthelmintic Activity of Crude Extracts of Artemisia herba-alba and Punica granatum against Haemonchus contortus. Journal of Parasitology Research, 2020, 1–7. doi:10.1155/2020/4950196
Hwang, S. H., Li, H. M., Lim, S. S., Wang, Z., Hong, J.-S., & Huang, B. (2016). Evaluation of a Standardized Extract fromMorus albaagainstα-Glucosidase Inhibitory Effect and Postprandial Antihyperglycemic in Patients with Impaired Glucose Tolerance: A Randomized Double-Blind Clinical Trial. Evidence-Based Complementary and Alternative Medicine, 2016, 1–10. doi:10.1155/2016/8983232
Springer Link
Sridhar S.N.C., George G., Verma A., Paul A.T. (2019) Natural Products-Based Pancreatic Lipase Inhibitors for Obesity Treatment. In: Akhtar M., Swamy M., Sinniah U. (eds) Natural Bio-active Compounds. Springer, Singapore. https://doi.org/10.1007/978-981-13-7154-7_6
Lawal, B., Shittu, O.K., Oibiokpa, F.I. et al. African natural products with potential antioxidants and hepatoprotectives properties: a review. Clin Phytosci 2, 23 (2017). https://doi.org/10.1186/s40816-016-0037-0