Tabernaemontana alba

Generalidades

Sinónimos: No aplican.

Nombre común: Huevo de gato (en la zona). Cojón de gato, lecherillo, palo de San Diego, t'abat (huasteco) (fuera de la zona).

Características generales:


  • Tabernaemontana es un género con 100-110 especies de plantas de flores pertenecientes a la familia Apocynaceae, con una distribución tropical.

  • Son arbustos y pequeños árboles que alcanza 1-15 metros de altura.

  • Las hojas son perennes opuestas de 3-25 cm de longitud.

  • Las flores son olorosas, blancas de 1-5 cm de diámetro, sépalos pequeños más o menos iguales; corola hipocrateriforme; anteras no aglutinadas a la cabeza del estilo; ovario apocárpico.

  • Son arbustos o árboles con látex blanco y ramas bifurcadas.

  • Hojas opuestas, eglandulares. Inflorescencia cimoso-paniculada,

  • Fruto de 2 folículos cortos, carnosos, dehiscentes y exhibiendo las numerosas semillas con conspicuo arilo anaranjado.

Usos medicinales reportados


  • La decocción de la raíz se usa oralmente para tratar malaria, mordeduras de culebra, dolor de estómago, bajar la presión arterial, como depurador y febrífugo.

  • A la hoja, tallo, corteza y raíz se les atribuye propiedad febrífuga, antimalárica, antihipertensiva y sedante.

Usos farmacológicos reportados

  • Actividad antimicrobiana

  • Actividad antioxidante

  • Actividad antitumoral

  • Actividad citotóxica

  • Actividad antitumoral

  • Actividad antimicrobiana

  • Actividad anticancerígena

  • Actividad analgésica

  • Actividad antihelmíntica

  • Potencial anti-neuraminidasa

Bibliografías

PubMed

  1. Guzmán-Gutiérrez SL, Silva-Miranda M, Krengel F, Huerta-Salazar E, León-Santiago M, Díaz-Cantón JK, Espitia Pinzón C, Reyes-Chilpa R. Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea. Planta Med. 2020 May 11. doi: 10.1055/a-1157-1732. Epub ahead of print. Erratum in: Planta Med. 2020 May 18;: PMID: 32392600.

  2. Guzmán-Gutiérrez SL, Silva-Miranda M, Krengel F, Huerta-Salazar E, León-Santiago M, Díaz-Cantón JK, Espitia Pinzón C, Reyes-Chilpa R. Erratum: Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea. Planta Med. 2020 May 18. doi: 10.1055/a-1177-3691. Epub ahead of print. Erratum for: Planta Med. 2020 May 11;: PMID: 32422666.

  3. Krengel F, Mijangos MV, Reyes-Lezama M, Reyes-Chilpa R. Extraction and Conversion Studies of the Antiaddictive Alkaloids Coronaridine, Ibogamine, Voacangine, and Ibogaine from Two Mexican Tabernaemontana Species (Apocynaceae). Chem Biodivers. 2019 Jul;16(7):e1900175. doi: 10.1002/cbdv.201900175. Epub 2019 Jun 13. PMID: 31095891.

  4. Krengel F, Herrera Santoyo J, Olivera Flores TJ, Chávez Ávila VM, Pérez Flores FJ, Reyes Chilpa R. Quantification of Anti-Addictive Alkaloids Ibogaine and Voacangine in In Vivo- and In Vitro-Grown Plants of Two Mexican Tabernaemontana Species. Chem Biodivers. 2016 Dec;13(12):1730-1737. doi: 10.1002/cbdv.201600146. Epub 2016 Nov 17. PMID: 27448833.

Google Scholar

  1. Guzmán-Gutiérrez, S. L., Silva-Miranda, M., Krengel, F., Huerta-Salazar, E., León-Santiago, M., Díaz-Cantón, J. K., … Reyes-Chilpa, R. (2020). Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea. Planta Medica. doi:10.1055/a-1157-1732

  2. Krengel, F., Chevalier, Q., Dickinson, J., Santoyo, J. H., & Reyes-Chilpa, R. (2019). Metabolite Profiling of Antiaddictive Alkaloids from Four Mexican Tabernaemontana Species and the Entheogenic African Shrub Tabernanthe iboga (Apocynaceae). Chemistry & Biodiversity. doi:10.1002/cbdv.201800506 

  3. Shi, B.-B., Chen, J., Bao, M.-F., Zeng, Y., & Cai, X.-H. (2019). Alkaloids isolated from Tabernaemontana bufalina display xanthine oxidase inhibitory activity. Phytochemistry, 166, 112060. doi:10.1016/j.phytochem.2019.112060 

  4. Canaveze, Y., & Machado, S. R. (2016). The Occurrence of Intrusive Growth Associated with Articulated Laticifers in Tabernaemontana catharinensis A.DC., a New Record for Apocynaceae. International Journal of Plant Sciences, 177(5), 458–467. doi:10.1086/685446 

ScienceDirect

  1. Silveira, D., de Melo, A. M. M. F., Magalhães, P. O., & Fonseca-Bazzo, Y. M. (2017). Tabernaemontana Species: Promising Sources of New Useful Drugs. Studies in Natural Products Chemistry, 227–289. doi:10.1016/b978-0-444-63929-5.00007-3 

  2. Hernández-Castro, C., Diaz-Castillo, F., & Martínez-Gutierrez, M. (2015). Ethanol extracts of Cassia grandis and Tabernaemontana cymosa inhibit the in vitro replication of dengue virus serotype 2. Asian Pacific Journal of Tropical Disease, 5(2), 98–106. doi:10.1016/s2222-1808(14)60635-6 

BioMed Research International

  1. Khan, W., Subhan, S., Shams, D. F., Afridi, S. G., Ullah, R., Shahat, A. A., & Alqahtani, A. S. (2019). Antioxidant Potential, Phytochemicals Composition, and Metal Contents of Datura alba. BioMed Research International, 2019, 1–8. doi:10.1155/2019/2403718

  2. De Oliveira, A. M., Mesquita, M. da S., da Silva, G. C., de Oliveira Lima, E., de Medeiros, P. L., Paiva, P. M. G., … Napoleão, T. H. (2015). Evaluation of Toxicity and Antimicrobial Activity of an Ethanolic Extract from Leaves of Morus alba L. (Moraceae). Evidence-Based Complementary and Alternative Medicine, 2015, 1–7. doi:10.1155/2015/513978 

  3. Kim, H., & Chung, M. S. (2018). Antiviral Activities of Mulberry (Morus alba) Juice and Seed against Influenza Viruses. Evidence-Based Complementary and Alternative Medicine, 2018, 1–10. doi:10.1155/2018/2606583 

  4. Baskaran, G., Salvamani, S., Azlan, A., Ahmad, S. A., Yeap, S. K., & Shukor, M. Y. (2015). Hypocholesterolemic and Antiatherosclerotic Potential ofBasella albaLeaf Extract in Hypercholesterolemia-Induced Rabbits. Evidence-Based Complementary and Alternative Medicine, 2015, 1–7. doi:10.1155/2015/751714 

  5. Su-Hong, C., Qi, C., Bo, L., Jian-Li, G., Jie, S., & Gui-Yuan, L. (2015). Antihypertensive Effect of Radix Paeoniae Alba in Spontaneously Hypertensive Rats and Excessive Alcohol Intake and High Fat Diet Induced Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine, 2015, 1–8. doi:10.1155/2015/731237 

  6. Soonthornsit, N., Pitaksutheepong, C., Hemstapat, W., Utaisincharoen, P., & Pitaksuteepong, T. (2017). In Vitro Anti-Inflammatory Activity of Morus alba L. Stem Extract in LPS-Stimulated RAW 264.7 Cells. Evidence-Based Complementary and Alternative Medicine, 2017, 1–8. doi:10.1155/2017/3928956 

  7. Islam, M. S., Rahi, M. S., Jahangir, C. A., Rahman, M. H., Jerin, I., Amin, R., … Reza, M. A. (2018). In Vivo Anticancer Activity of Basella alba Leaf and Seed Extracts against Ehrlich’s Ascites Carcinoma (EAC) Cell Line. Evidence-Based Complementary and Alternative Medicine, 2018, 1–11. doi:10.1155/2018/1537896 

  8. Kalman, D. S., & Hewlings, S. J. (2017). The Effects of Morus alba and Acacia catechu on Quality of Life and Overall Function in Adults with Osteoarthritis of the Knee. Journal of Nutrition and Metabolism, 2017, 1–9. doi:10.1155/2017/4893104 

  9. Ahmed, A. H., Ejo, M., Feyera, T., Regassa, D., Mummed, B., & Huluka, S. A. (2020). In Vitro Anthelmintic Activity of Crude Extracts of Artemisia herba-alba and Punica granatum against Haemonchus contortus. Journal of Parasitology Research, 2020, 1–7. doi:10.1155/2020/4950196 

  10. Hwang, S. H., Li, H. M., Lim, S. S., Wang, Z., Hong, J.-S., & Huang, B. (2016). Evaluation of a Standardized Extract fromMorus albaagainstα-Glucosidase Inhibitory Effect and Postprandial Antihyperglycemic in Patients with Impaired Glucose Tolerance: A Randomized Double-Blind Clinical Trial. Evidence-Based Complementary and Alternative Medicine, 2016, 1–10. doi:10.1155/2016/8983232 

Springer Link

  1. Sridhar S.N.C., George G., Verma A., Paul A.T. (2019) Natural Products-Based Pancreatic Lipase Inhibitors for Obesity Treatment. In: Akhtar M., Swamy M., Sinniah U. (eds) Natural Bio-active Compounds. Springer, Singapore. https://doi.org/10.1007/978-981-13-7154-7_6

  2. Lawal, B., Shittu, O.K., Oibiokpa, F.I. et al. African natural products with potential antioxidants and hepatoprotectives properties: a review. Clin Phytosci 2, 23 (2017). https://doi.org/10.1186/s40816-016-0037-0