Mark S. Klempner- Grants

Mark S Klempner

Summary

Affiliation: Boston University

Country: USA

Research Grants

1. Lyme Disease: Spirochete Invasion and Host Immunity
2. Mark S Klempner; Fiscal Year: 2005
3. National Center/Emerging Infectous Diseases & Biodefense
4. Mark S Klempner; Fiscal Year: 2006
5. New Method for Detecting Bacillus Anthracis Spores
6. Mark S Klempner; Fiscal Year: 2003
7. National Center/Emerging Infectous Diseases & Biodefense
8. Mark S Klempner; Fiscal Year: 2003
9. National Emerging Infectious Diseases Laboratories Operations
10. Mark S Klempner; Fiscal Year: 2008
11. Environmental Health and Safety Core
12. Mark S Klempner; Fiscal Year: 2008
13. Administrative Core
14. Mark S Klempner; Fiscal Year: 2008

Publications

1. Controlled trials of antibiotic treatment in patients with post-treatment chronic Lyme disease
2. Mark S Klempner
3. Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
4. Vector Borne Zoonotic Dis 2:255-63
5. Selective up-regulation of matrix metalloproteinase-9 expression in human erythema migrans skin lesions of acute lyme disease
6. Zhihui Zhao
7. Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
8. J Infect Dis 188:1098-104
9. A case-control study to examine HLA haplotype associations in patients with posttreatment chronic Lyme disease
10. Mark S Klempner
11. Boston University School of Medicine and Boston Medical Center, Massachusetts 02118, USA
12. J Infect Dis 192:1010-3
13. CD14 mediates cross talk between mononuclear cells and fibroblasts for upregulation of matrix metalloproteinase 9 by Borrelia burgdorferi
14. Zhihui Zhao
15. Boston Medical Center, 650 Albany Street, Boston, MA 02118, USA
16. Infect Immun 75:3062-9
17. Borrelia burgdorferi-induced monocyte chemoattractant protein-1 production in vivo and in vitro
18. Zhihui Zhao
19. Section of Infectious Diseases, Boston University Medical Center, Boston, MA 02118, USA
20. Biochem Biophys Res Commun 358:528-33
21. Analysis of differences in the functional properties of the substrate binding proteins of the Borrelia burgdorferi oligopeptide permease (Opp) operon
22. Xing-Guo Wang
23. Tupper Research Institute, Division of Geographic Medicine and Infectious Diseases, New England Medical Center, Boston, Massachusetts 02111, USA
24. J Bacteriol 186:51-60
25. The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America
26. Gary P Wormser
27. Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
28. Clin Infect Dis 43:1089-134

Collaborators

• Zhihui Zhao
• J Tang
• Linden T Hu
• Raymond J Dattwyler
• Peter J Krause
• John J Halperin
• Eugene D Shapiro
• Allen C Steere
• G Stanek
• J Stephen Dumler
• R A Kaslow
• Robert B Nadelman
• Gary P Wormser
• Xing-Guo Wang
• J Michael Kidder
• Joanna P Scagliotti
• Richard Noring

Detail Information

Research Grants7

1. Lyme Disease: Spirochete Invasion and Host Immunity
2. Mark S Klempner; Fiscal Year: 2005
3. ..This abstract is not available...
4. National Center/Emerging Infectous Diseases & Biodefense
5. Mark S Klempner; Fiscal Year: 2006
6. ....
7. New Method for Detecting Bacillus Anthracis Spores
8. Mark S Klempner; Fiscal Year: 2003
9. ..anthracis spores and spores of other related and unrelated bacteria. The project will focus on developing the ligand library to include non-antibody reagents and differential recognition of bacterial spores from multiple species...
10. National Center/Emerging Infectous Diseases & Biodefense
11. Mark S Klempner; Fiscal Year: 2003
12. ..Public Health Relevance: This Public Health Relevance is not available...
13. National Emerging Infectious Diseases Laboratories Operations
14. Mark S Klempner; Fiscal Year: 2008
15. ..Program activities may also be based at the Charles River Campus of Boston University and at offsite locations as appropriate. Public Health Relevance: This Public Health Relevance is not available...
16. Environmental Health and Safety Core
17. Mark S Klempner; Fiscal Year: 2008
18. ..Public Health Relevance: This Public Health Relevance is not available...
19. Administrative Core
20. Mark S Klempner; Fiscal Year: 2008
21. ..This abstract is not available. Public Health Relevance: This Public Health Relevance is not available...

Publications7

1. Controlled trials of antibiotic treatment in patients with post-treatment chronic Lyme disease
2. Mark S Klempner
3. Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
4. Vector Borne Zoonotic Dis 2:255-63
5. ....
6. Selective up-regulation of matrix metalloproteinase-9 expression in human erythema migrans skin lesions of acute lyme disease
7. Zhihui Zhao
8. Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
9. J Infect Dis 188:1098-104
10. ..These results demonstrate specific up-regulation of MMP-9 in the EM skin lesions of patients with acute Lyme disease. Bacterial induction of host proteases may play a role in the dissemination of B. burgdorferi...
11. A case-control study to examine HLA haplotype associations in patients with posttreatment chronic Lyme disease
12. Mark S Klempner
13. Boston University School of Medicine and Boston Medical Center, Massachusetts 02118, USA
14. J Infect Dis 192:1010-3
15. ..No strong association between posttreatment chronic Lyme disease and any class II allele or genotype was found...
16. CD14 mediates cross talk between mononuclear cells and fibroblasts for upregulation of matrix metalloproteinase 9 by Borrelia burgdorferi
17. Zhihui Zhao
18. Boston Medical Center, 650 Albany Street, Boston, MA 02118, USA
19. Infect Immun 75:3062-9
20. ..These data suggest that the upregulation of MMP-9 by B. burgdorferi involves the CD14 pathway in infiltrating inflammatory cells. Fibroblasts could be recruited to amplify local production of MMP-9 by acquiring CD14 from macrophages...
21. Borrelia burgdorferi-induced monocyte chemoattractant protein-1 production in vivo and in vitro
22. Zhihui Zhao
23. Section of Infectious Diseases, Boston University Medical Center, Boston, MA 02118, USA
24. Biochem Biophys Res Commun 358:528-33
25. ..The secreted MCP-1 may affect the production of MMP-9 in fibroblasts and/or macrophages...
26. Analysis of differences in the functional properties of the substrate binding proteins of the Borrelia burgdorferi oligopeptide permease (Opp) operon
27. Xing-Guo Wang
28. Tupper Research Institute, Division of Geographic Medicine and Infectious Diseases, New England Medical Center, Boston, Massachusetts 02111, USA
29. J Bacteriol 186:51-60
30. ..OppA-3 showed the greatest tolerance for changes in stereochemistry. Substantial differences in the substrate specificities of the OppA proteins of B. burgdorferi suggest that they may have distinct functions in the organism...
31. The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America
32. Gary P Wormser
33. Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
34. Clin Infect Dis 43:1089-134
35. ..Tables list the doses and durations of antimicrobial therapy recommended for treatment and prevention of Lyme disease and provide a partial list of therapies to be avoided. A definition of post-Lyme disease syndrome is proposed...
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