Institute of Medicine

COMMITTEE ON LYME DISEASE AND OTHER TICK-BORNE DISEASES: THE STATE OF THE SCIENCE 1

CRITICAL NEEDS AND GAPS IN UNDERSTANDING PREVENTION, AMELIORATION,AND RESOLUTION OF LYME AND OTHER TICK-BORNE DISEASES: THE SHORT-TERM AND LONG-TERM OUTCOMES

October 11-12, 2010

Adams & Franklin Room

Washington Plaza Hotel

10 Thomas Circle, NW

Washington, DC

AGENDA

DAY ONE: OCTOBER 11, 2010

8:00 am Introduction

Lonnie King, D.V.M., M.S., M.A.

Chair, Committee on Lyme Disease and Other Tick-Borne Diseases

Dean, College of Veterinary Medicine

The Ohio State University

8:15 am A Systems Approach in Understanding Tick-Borne Diseases: People, Animals, and the

Ecosystem

Richard Ostfeld, Ph.D. (confirmed)

Disease Ecologist

Cary Institute of Ecosystem Studies

8:40 am Discussion

SURVEILLANCE, SPECTRUM, AND BURDEN OF TICK-BORNE DISEASES

9:00 am Moderator: Gordon Schutze, M.D.

Committee Member, Committee on Lyme Disease and Other Tick-Borne

Diseases

Professor and Vice-Chairman for Educational Affairs

Department of Pediatrics

Vice President, Baylor International Pediatric AIDS Initiative

Baylor College of Medicine

Texas Children's Hospital

9:05 am Landscape of Lyme Disease: Current Knowledge, Gaps, and

Research Needs

Gary P. Wormser, M. D. (confirmed)

Professor of Medicine

Chief, Division of Infectious Diseases

Vice-Chairman, Department of Medicine

New York Medical College

2

9:30 am Recent Understanding of Babesiosis: Clinical Manifestation, Co-infection, and Research

Needs

Peter Krause, M.D. (confirmed)

Senior Research Scientist

Lecturer in Epidemiology, Microbial Diseases

Yale School of Public Health

9:45 am Discussion

10:05 am Break

10:20 am Insights into Ehrlichia & Anaplasma: Surveillance, Co-infection, and Research Needs

J. Stephen Dumler, M.D. (confirmed)

Professor, Department of Pathology

Division of Medical Microbiology

Johns Hopkins University School of Medicine

10:40 am Rickettsia Diseases: Spectrum of Disease, Spatial Clustering, At-Risk Populations, and

Research Needs

Jennifer McQuiston, D.V.M, M.S. (confirmed)

National Center for Preparedness, Detection, and Control of Infectious Diseases

Centers for Disease Control and Prevention

11:00 am Research Needs and Gaps for Tick-Borne Diseases

Carl Brenner (confirmed)

National Research Fund for Tick-Borne Diseases, Inc.

11:20 am Discussion

11:40 am Panel: Disease Surveillance & Co-infection

Carl Brenner, Stephen Dumler, Peter Krause, Jennifer McQuiston,

and Gary Wormser

12:25 pm Summation: Unifying Knowledge Gaps and Needs

Gordon Schutze

12:35 pm LUNCH (45 minutes)

AT-RISK POPULATIONS AND

HUMAN FACE OF TICK-BORNE DISEASES

1:20 pm Moderator: Lonnie King

1:25 pm Panel: Genetic and Acquired Determinants of Host Susceptibility and Vulnerable

Populations

David Weber, M.D. (invited)

Professor of Medicine and Pediatrics, School of Medicine

Professor of Epidemiology, School of Public Health

University of North Carolina

3

TBA

Peter Krause, M.D. (confirmed)

Senior Research Scientist

Lecturer in Epidemiology Microbial Diseases

Yale School of Public Health

1:50 pm Discussion

2:05 pm The Human Face of Tick-Borne Disease Infections

Pamela Weintraub (confirmed)

Author, Cure Unknown

Editor, Discover Magazine

2:25 pm Discussion

2:55 pm Break

DIAGNOSTICS AND DIAGNOSIS

3:05 pm Moderators: Lynn Gerber, M.D.

Committee Member, Committee on Lyme Disease and Other Tick-Borne

Diseases

Director, Center for the Study of Chronic Illness and Disability

College of Health and Human Services

George Mason University

David H. Walker, M.D.

Committee Member, Committee on Lyme Disease and Other Tick-Borne

Diseases

Professor and Chair

Department of Pathology

University of Texas Medical Branch at Galveston

3:10 pm Diagnostics for Lyme Disease: Knowledge Gaps and

Needs

Maria Aguero-Rosenfeld, M.D. (confirmed)

Professor of Pathology

Director of Clinical Pathology and Microbiology Laboratory

Bellevue Hospital Center

3:30 pm Improved Diagnostics & Novel Approaches to Tick-Borne Disease Infections

Juan Olano, M.D. (confirmed)

Associate Professor, Department of Pathology

Director, Residency Training Program

University of Texas Medical Branch Center

4

3:50 pm Potential Bio-Marker Applications for Lyme Disease: Aligning Multiple Symptoms with

Biological Measures

Afton Hassett, Psy.D. (confirmed)

Associate Research Scientist, Department of Anesthesiology

Chronic Pain & Fatigue Research Center

University of Michigan Medical School

4:10 pm Discussion

4:40 pm Panel: Challenges for Clinicians in Diagnosis and Management of Chronic Illness

Manifestations: Knowledge Gaps

Sam T. Donta, M.D. (confirmed)

Infectious Disease Specialist

Falmouth Hospital, Massachusetts

Brian Fallon, M.D., M.P.H. (confirmed)

Director of the Center for Neuroinflammatory Disorders and Biobehavioral

Medicine

Director of the Lyme and Tick-Borne Diseases Research Center

Columbia University Medical Center

Matthew Liang, M.D., M.P.H. (confirmed)

Professor, Department of Health Policy and Management

Harvard School of Public Health

Richard F. Jacobs, M.D., F.A.A.P.

(confirmed)

Robert H. Fiser, Jr., M.D. Endowed Chair in Pediatrics

Chairman, Department of Pediatrics

University of Arkansas for Medical Sciences

President, Arkansas Children’s Hospital Research Institute

5:20 pm Discussion

5:45 pm Summation

Lynn Gerber and David Walker

6:00 pm Adjourn

5

CRITICAL NEEDS AND GAPS IN UNDERSTANDING PREVENTION, AMELIORATION,AND RESOLUTION

OF LYME AND OTHER TICK-BORNE DISEASES: THE SHORT-TERM AND LONG-TERM OUTCOMES

AGENDA

DAY TWO: OCTOBER 12, 2010

8:00 am Introduction

Lonnie King

EMERGING INFECTIONS, TICK BIOLOGY, AND HOST-VECTOR INTERACTIONS

Moderator: Lonnie King

8:05 am Emerging and Re-Emerging Tick-Borne Infections

Ulrike Munderloh, S.M. (confirmed)

Associate Professor, Department of Entomology

University of Minnesota

8:25 am Natural History of Ticks: Evolution, Adaptation and Biology

Thomas G. Schwan, Ph.D. (confirmed)

Chief, Laboratory of Zoonotic Pathogens

Chief, Medical Entomology Section

National Institute of Allergy and Infectious Diseases

8:45 am Wildlife and Domestic Hosts: Their Important Roles in Maintaining, Amplifying,

Carrying Agents and their Changing Dynamics

Howard Ginsberg, Ph.D. (confirmed)

Research Ecologist

United States Geological Survey

Professor in Residence, Department of Plant Science

University of Rhode Island

9:05 am Discussion

9:20 am Emerging Tick-Borne Diseases: Geographic Distribution and Host Reservoirs

Edward Breitschwerdt, D.V.M. (confirmed)

Professor of Internal Medicine, College of Veterinary Medicine

North Carolina State University

Adjunct Associate Professor of Medicine

Duke University Medical Center

9:40 am Variation of Borrelia Subspecies: Implications for Human Disease

James H. Oliver, Jr., Ph.D.

Director, Institute of Arthropodology and Parasitology

Callaway Professor of Biology

Georgia Southern University

10:00 am Discussion

6

10:20 am Break

PATHOGENESIS

10:30 am Moderator: Guy Palmer, D.V.M., Ph.D.

Committee Member, Committee on Lyme Disease and Other Tick-Borne

Diseases

Regents Professor of Pathology and Infectious Diseases

The Creighton Chair and Director, School for Global Animal Health

Washington State University

10:35 am Pathogenesis of Borrelia burgdorferi Infection and Disease

Janis Weis, Ph.D. (confirmed)

Professor of Pathology, Department of Pathology

University of Utah

10:55 am Duration of Spirochete Infection Following Antibiotic Treatment in Animals

Linda Bockenstedt, M.D. (confirmed)

Harold W. Jockers Professor of Medicine

Department of Rheumatology

Yale School of Medicine

11:15 am Discussion

11:30 am Antigenic Variation as a Mechanism for Persistent

Borrelia Infection

Stephen Norris, Ph.D. (confirmed)

Greer Professor

Vice Chair for Research

Pathology & Laboratory Medicine, University of Texas, Houston

11:50 am Sequestration as a Mechanism for Persistent Borrelia Infection

Steven Barthold, DVM, Ph.D.

Distinguished Professor

Department of Pathology, Microbiology and Immunology

Center of Comparative Medicine

School of Veterinary Medicine

University of California, Davis (confirmed)

12:10 pm Discussion

12:30 pm LUNCH (45 minutes)

1:15 pm Pathogenesis of Ehrlichia and Anaplasma Infection and Disease

Nahed Ismail, M.D., M.Sc., Ph.D., S.M. (ASCP), D. (ABMM) (confirmed)

Associate Professor, Department of Pathology

Meharry Medical College

7

1:35 pm Pathogenesis of Rickettsia Infection and Disease

Gustavo Valbuena, M.D.

Instructor, Department of Pathology

University of Texas Medical Branch (confirmed)

1:55 pm Discussion

2:15 pm Summation

Guy Palmer

SCIENCE, SOCIETY, AND DISEASE

2:20 pm Moderator: Lynn Gerber

2:25 pm The Social Construction of Lyme Disease

Robert Aronowitz, M.D. (confirmed)

Professor, Department of History and Sociology of Science

University of Pennsylvania

2:45 pm Discussion

2:55 pm Break

PREVENTION

3:05 pm Moderator: Stephen M. Ostroff, M.D.

Committee Member, Committee on Lyme Disease and Other Tick-Borne

Diseases

Director, Bureau of Epidemiology

Pennsylvania Department of Health

3:10 pm Current Vaccines for Tick-Borne Disease Infections and Vaccine Development

Jere McBride, Ph.D., M.S. (confirmed)

Associate Professor, Department of Pathology

University of Texas Medical Branch

3:30 pm Developing Opportunities for Future Vaccines

Wendy Brown, Ph.D., M.P.H. (confirmed)

Regents Professor, Department of Veterinary Microbiology and Pathology

Washington State University

3:50 pm Discussion

4:10 pm Education, Behavior Change, and Other Non-Pharmaceutical Measures Against Lyme

and Other Tick-Borne Diseases

Paul Mead, M.D., M.P.H.

Medical Epidemiologist, Division of Vector-Borne Infectious Diseases

National Center for Infectious Diseases

Center for Disease Control and Prevention

8

4:30 pm Vector- and Host-Targeted Strategies for Prevention of Tick-Borne Diseases

José M.C. Ribeiro, M.D., Ph.D. (confirmed)

Chief, Vector Biology Section

Laboratory of Malaria and Vector Research

National Institute of Allergy and Infectious Diseases

4:50 pm Discussion

5:10 pm Summation

Steve Ostroff

CLOSING

5:20 pm Moderator: Lonnie King

5:25 pm Panel: State of Science, General Research Gaps and Opportunities in Tick-Borne

Diseases

John Aucott, M.D. (confirmed)

Founder, Lyme Disease Research Foundation of Maryland

Physician, Park Medical Associates

Diane Blanchard (confirmed)

Co-President, Time for Lyme, Inc.

Linda Bockenstedt, M.D. (confirmed)

Harold W. Jockers Professor of Medicine

Department of Rheumatology

Yale School of Medicine

J. Stephen Dumler, M.D. (confirmed)

Professor, Department of Pathology

Division of Medical Microbiology

Johns Hopkins University School of Medicine

Susan O’Connell, M.D. (confirmed)

Consultant Microbiologist

Head of the Lyme Borreliosis Unit

Southampton General Hospital

5:55 pm Discussion

6:25 pm Final Summation and Closing Remarks

Lonnie King

6:35 pm Adjourn