COMMITTEE ON LYME DISEASE AND OTHER TICK-BORNE DISEASES: THE STATE OF THE SCIENCE 1
CRITICAL NEEDS AND GAPS IN UNDERSTANDING PREVENTION, AMELIORATION,AND RESOLUTION OF LYME AND OTHER TICK-BORNE DISEASES: THE SHORT-TERM AND LONG-TERM OUTCOMES
October 11-12, 2010
Adams & Franklin Room
Washington Plaza Hotel
10 Thomas Circle, NW
Washington, DC
AGENDA
DAY ONE: OCTOBER 11, 2010
8:00 am Introduction
Lonnie King, D.V.M., M.S., M.A.
Chair, Committee on Lyme Disease and Other Tick-Borne Diseases
Dean, College of Veterinary Medicine
The Ohio State University
8:15 am A Systems Approach in Understanding Tick-Borne Diseases: People, Animals, and the
Ecosystem
Richard Ostfeld, Ph.D. (confirmed)
Disease Ecologist
Cary Institute of Ecosystem Studies
8:40 am Discussion
SURVEILLANCE, SPECTRUM, AND BURDEN OF TICK-BORNE DISEASES
9:00 am Moderator: Gordon Schutze, M.D.
Committee Member, Committee on Lyme Disease and Other Tick-Borne
Diseases
Professor and Vice-Chairman for Educational Affairs
Department of Pediatrics
Vice President, Baylor International Pediatric AIDS Initiative
Baylor College of Medicine
Texas Children's Hospital
9:05 am Landscape of Lyme Disease: Current Knowledge, Gaps, and
Research Needs
Gary P. Wormser, M. D. (confirmed)
Professor of Medicine
Chief, Division of Infectious Diseases
Vice-Chairman, Department of Medicine
New York Medical College
2
9:30 am Recent Understanding of Babesiosis: Clinical Manifestation, Co-infection, and Research
Needs
Peter Krause, M.D. (confirmed)
Senior Research Scientist
Lecturer in Epidemiology, Microbial Diseases
Yale School of Public Health
9:45 am Discussion
10:05 am Break
10:20 am Insights into Ehrlichia & Anaplasma: Surveillance, Co-infection, and Research Needs
J. Stephen Dumler, M.D. (confirmed)
Professor, Department of Pathology
Division of Medical Microbiology
Johns Hopkins University School of Medicine
10:40 am Rickettsia Diseases: Spectrum of Disease, Spatial Clustering, At-Risk Populations, and
Research Needs
Jennifer McQuiston, D.V.M, M.S. (confirmed)
National Center for Preparedness, Detection, and Control of Infectious Diseases
Centers for Disease Control and Prevention
11:00 am Research Needs and Gaps for Tick-Borne Diseases
Carl Brenner (confirmed)
National Research Fund for Tick-Borne Diseases, Inc.
11:20 am Discussion
11:40 am Panel: Disease Surveillance & Co-infection
Carl Brenner, Stephen Dumler, Peter Krause, Jennifer McQuiston,
and Gary Wormser
12:25 pm Summation: Unifying Knowledge Gaps and Needs
Gordon Schutze
12:35 pm LUNCH (45 minutes)
AT-RISK POPULATIONS AND
HUMAN FACE OF TICK-BORNE DISEASES
1:20 pm Moderator: Lonnie King
1:25 pm Panel: Genetic and Acquired Determinants of Host Susceptibility and Vulnerable
Populations
David Weber, M.D. (invited)
Professor of Medicine and Pediatrics, School of Medicine
Professor of Epidemiology, School of Public Health
University of North Carolina
3
TBA
Peter Krause, M.D. (confirmed)
Senior Research Scientist
Lecturer in Epidemiology Microbial Diseases
Yale School of Public Health
1:50 pm Discussion
2:05 pm The Human Face of Tick-Borne Disease Infections
Pamela Weintraub (confirmed)
Author, Cure Unknown
Editor, Discover Magazine
2:25 pm Discussion
2:55 pm Break
DIAGNOSTICS AND DIAGNOSIS
3:05 pm Moderators: Lynn Gerber, M.D.
Committee Member, Committee on Lyme Disease and Other Tick-Borne
Diseases
Director, Center for the Study of Chronic Illness and Disability
College of Health and Human Services
George Mason University
David H. Walker, M.D.
Committee Member, Committee on Lyme Disease and Other Tick-Borne
Diseases
Professor and Chair
Department of Pathology
University of Texas Medical Branch at Galveston
3:10 pm Diagnostics for Lyme Disease: Knowledge Gaps and
Needs
Maria Aguero-Rosenfeld, M.D. (confirmed)
Professor of Pathology
Director of Clinical Pathology and Microbiology Laboratory
Bellevue Hospital Center
3:30 pm Improved Diagnostics & Novel Approaches to Tick-Borne Disease Infections
Juan Olano, M.D. (confirmed)
Associate Professor, Department of Pathology
Director, Residency Training Program
University of Texas Medical Branch Center
4
3:50 pm Potential Bio-Marker Applications for Lyme Disease: Aligning Multiple Symptoms with
Biological Measures
Afton Hassett, Psy.D. (confirmed)
Associate Research Scientist, Department of Anesthesiology
Chronic Pain & Fatigue Research Center
University of Michigan Medical School
4:10 pm Discussion
4:40 pm Panel: Challenges for Clinicians in Diagnosis and Management of Chronic Illness
Manifestations: Knowledge Gaps
Sam T. Donta, M.D. (confirmed)
Infectious Disease Specialist
Falmouth Hospital, Massachusetts
Brian Fallon, M.D., M.P.H. (confirmed)
Director of the Center for Neuroinflammatory Disorders and Biobehavioral
Medicine
Director of the Lyme and Tick-Borne Diseases Research Center
Columbia University Medical Center
Matthew Liang, M.D., M.P.H. (confirmed)
Professor, Department of Health Policy and Management
Harvard School of Public Health
Richard F. Jacobs, M.D., F.A.A.P.
(confirmed)
Robert H. Fiser, Jr., M.D. Endowed Chair in Pediatrics
Chairman, Department of Pediatrics
University of Arkansas for Medical Sciences
President, Arkansas Children’s Hospital Research Institute
5:20 pm Discussion
5:45 pm Summation
Lynn Gerber and David Walker
6:00 pm Adjourn
5
CRITICAL NEEDS AND GAPS IN UNDERSTANDING PREVENTION, AMELIORATION,AND RESOLUTION
OF LYME AND OTHER TICK-BORNE DISEASES: THE SHORT-TERM AND LONG-TERM OUTCOMES
AGENDA
DAY TWO: OCTOBER 12, 2010
8:00 am Introduction
Lonnie King
EMERGING INFECTIONS, TICK BIOLOGY, AND HOST-VECTOR INTERACTIONS
Moderator: Lonnie King
8:05 am Emerging and Re-Emerging Tick-Borne Infections
Ulrike Munderloh, S.M. (confirmed)
Associate Professor, Department of Entomology
University of Minnesota
8:25 am Natural History of Ticks: Evolution, Adaptation and Biology
Thomas G. Schwan, Ph.D. (confirmed)
Chief, Laboratory of Zoonotic Pathogens
Chief, Medical Entomology Section
National Institute of Allergy and Infectious Diseases
8:45 am Wildlife and Domestic Hosts: Their Important Roles in Maintaining, Amplifying,
Carrying Agents and their Changing Dynamics
Howard Ginsberg, Ph.D. (confirmed)
Research Ecologist
United States Geological Survey
Professor in Residence, Department of Plant Science
University of Rhode Island
9:05 am Discussion
9:20 am Emerging Tick-Borne Diseases: Geographic Distribution and Host Reservoirs
Edward Breitschwerdt, D.V.M. (confirmed)
Professor of Internal Medicine, College of Veterinary Medicine
North Carolina State University
Adjunct Associate Professor of Medicine
Duke University Medical Center
9:40 am Variation of Borrelia Subspecies: Implications for Human Disease
James H. Oliver, Jr., Ph.D.
Director, Institute of Arthropodology and Parasitology
Callaway Professor of Biology
Georgia Southern University
10:00 am Discussion
6
10:20 am Break
PATHOGENESIS
10:30 am Moderator: Guy Palmer, D.V.M., Ph.D.
Committee Member, Committee on Lyme Disease and Other Tick-Borne
Diseases
Regents Professor of Pathology and Infectious Diseases
The Creighton Chair and Director, School for Global Animal Health
Washington State University
10:35 am Pathogenesis of Borrelia burgdorferi Infection and Disease
Janis Weis, Ph.D. (confirmed)
Professor of Pathology, Department of Pathology
University of Utah
10:55 am Duration of Spirochete Infection Following Antibiotic Treatment in Animals
Linda Bockenstedt, M.D. (confirmed)
Harold W. Jockers Professor of Medicine
Department of Rheumatology
Yale School of Medicine
11:15 am Discussion
11:30 am Antigenic Variation as a Mechanism for Persistent
Borrelia Infection
Stephen Norris, Ph.D. (confirmed)
Greer Professor
Vice Chair for Research
Pathology & Laboratory Medicine, University of Texas, Houston
11:50 am Sequestration as a Mechanism for Persistent Borrelia Infection
Steven Barthold, DVM, Ph.D.
Distinguished Professor
Department of Pathology, Microbiology and Immunology
Center of Comparative Medicine
School of Veterinary Medicine
University of California, Davis (confirmed)
12:10 pm Discussion
12:30 pm LUNCH (45 minutes)
1:15 pm Pathogenesis of Ehrlichia and Anaplasma Infection and Disease
Nahed Ismail, M.D., M.Sc., Ph.D., S.M. (ASCP), D. (ABMM) (confirmed)
Associate Professor, Department of Pathology
Meharry Medical College
7
1:35 pm Pathogenesis of Rickettsia Infection and Disease
Gustavo Valbuena, M.D.
Instructor, Department of Pathology
University of Texas Medical Branch (confirmed)
1:55 pm Discussion
2:15 pm Summation
Guy Palmer
SCIENCE, SOCIETY, AND DISEASE
2:20 pm Moderator: Lynn Gerber
2:25 pm The Social Construction of Lyme Disease
Robert Aronowitz, M.D. (confirmed)
Professor, Department of History and Sociology of Science
University of Pennsylvania
2:45 pm Discussion
2:55 pm Break
PREVENTION
3:05 pm Moderator: Stephen M. Ostroff, M.D.
Committee Member, Committee on Lyme Disease and Other Tick-Borne
Diseases
Director, Bureau of Epidemiology
Pennsylvania Department of Health
3:10 pm Current Vaccines for Tick-Borne Disease Infections and Vaccine Development
Jere McBride, Ph.D., M.S. (confirmed)
Associate Professor, Department of Pathology
University of Texas Medical Branch
3:30 pm Developing Opportunities for Future Vaccines
Wendy Brown, Ph.D., M.P.H. (confirmed)
Regents Professor, Department of Veterinary Microbiology and Pathology
Washington State University
3:50 pm Discussion
4:10 pm Education, Behavior Change, and Other Non-Pharmaceutical Measures Against Lyme
and Other Tick-Borne Diseases
Paul Mead, M.D., M.P.H.
Medical Epidemiologist, Division of Vector-Borne Infectious Diseases
National Center for Infectious Diseases
Center for Disease Control and Prevention
8
4:30 pm Vector- and Host-Targeted Strategies for Prevention of Tick-Borne Diseases
José M.C. Ribeiro, M.D., Ph.D. (confirmed)
Chief, Vector Biology Section
Laboratory of Malaria and Vector Research
National Institute of Allergy and Infectious Diseases
4:50 pm Discussion
5:10 pm Summation
Steve Ostroff
CLOSING
5:20 pm Moderator: Lonnie King
5:25 pm Panel: State of Science, General Research Gaps and Opportunities in Tick-Borne
Diseases
John Aucott, M.D. (confirmed)
Founder, Lyme Disease Research Foundation of Maryland
Physician, Park Medical Associates
Diane Blanchard (confirmed)
Co-President, Time for Lyme, Inc.
Linda Bockenstedt, M.D. (confirmed)
Harold W. Jockers Professor of Medicine
Department of Rheumatology
Yale School of Medicine
J. Stephen Dumler, M.D. (confirmed)
Professor, Department of Pathology
Division of Medical Microbiology
Johns Hopkins University School of Medicine
Susan O’Connell, M.D. (confirmed)
Consultant Microbiologist
Head of the Lyme Borreliosis Unit
Southampton General Hospital
5:55 pm Discussion
6:25 pm Final Summation and Closing Remarks
Lonnie King
6:35 pm Adjourn