Robert Edelman

Robert Edelman M.D.

Academic Title: Clinical Professor

Primary Appointment: Medicine

Secondary Appointments: Pediatrics

redelman@medicine.umaryland.edu

Location: HSF 1, Room 480

Phone: (410) 706-5328

Fax: (410) 706-6205

Personal History

Dr. Edelman is Professor of Medicine in the Division of Geographic Medicine, Professor of Pediatrics in the Division of Infectious Diseases and Tropical Pediatrics, and Associate Director for Clinical Research at the Center for Vaccine Development, University of Maryland School of Medicine. He received his A.B. degree (Phi Beta Kappa) and M.D. degree, cum laude and AOA, from Washington University, St. Louis, in 1962. He trained in Pathology and Medicine at The Johns Hopkins Hospital (1962-64) and in Medicine at Barnes Hospital, St. Louis (1964-65) and was a USPHS Fellow in Preventive Medicine and Viral Immunology at Case Western Reserve University (1965 to 1968).

Dr. Edelman served several assignments in the U.S. Army from 1968 to 1976. These assignment included: Chief, Communicable Diseases and Immunology Research Branch, U.S. Army Medical Research and Development Command, Office of the Surgeon General, Washington, D.C. (1968 1970); Acting Chief and Clinical Investigator, Department of Virology, Walter Reed Overseas Research Team at SEATO Medical Research Laboratory, Bangkok, Thailand (1970-1973); Chief, Medical Division, U.S. Army Medical Research Institute of Infectious Diseases; Director of Medical Activities, Fort Detrick, MD (1973 1974), Principal Investigator, Virology Division, US Army Medical Research Institute of Infectious Diseases (1974 1976). During this time he investigated the pathogenesis and epidemiology of arbovirus infections, the relationship between malnutrition and immunity, and he performed Phase 1 clinical trials of several viral vaccines, including vaccines against the bioterror agents, Tularemia and Venezuelan Equine Encephalomyelitis (VEE) virus.

Dr. Edelman moved to the NIAID in 1976, and until 1988, when he retired from the U.S. Public Health Service, he held many positions in administration, clinical research and teaching. He served as Deputy Director of the Microbiology and Infectious Disease Program at NIAID (a 180 million dollar extramural research program) and as Chief of the Clinical and Epidemiological Studies Branch. Despite his heavy administrative load, he continued to conduct clinical research, especially on Lyme disease, on the role of maternal vaginal infections as a cause of low infant birth weight, and clinical trials of new antifungal drugs. Dr. Edelman earned three service medals for his achievements during his tenure in the Army and USPHS.

At the University of Maryland since 1988, Dr. Edelman has served as a senior consultant on vaccine development to the biotechnology industry, major pharmaceutical houses, the World Health Organization, the NIH, the Department of Defense, the U.S. Agency for International Development, and the Gates Foundation's Malaria Vaccine Initiative and the Pediatric Dengue Vaccine Initiative. As the Associate Director for Clinical Research at the CVD, Dr. Edelman serves to stimulate, coordinate and conduct clinical research. Dr. Edelman has served as lead investigator on clinical trials of experimental or licensed vaccines or biologicals in healthy young or elderly volunteers against a wide variety of infectious diseases. Such diseases include dengue, malaria, Lyme disease, Botulinum toxin, Chikungunya virus, diarrheal diseases, whooping cough, pneumococcal disease, hepatitis B virus, smallpox and most recently, seasonal and avian influenza. These studies were/are supported by the NIH, the U.S. Army, private foundations and industry.

He was the P.I. of the University of Maryland Immunosenescence/Immunosupression Research Group funded by the NIAID. He has a recognized expertise in clinical trials of vaccine adjuvants. He has been interviewed widely and quoted in the public Media regarding vaccines against bioterror agents, avian influenza and other emerging infections. He is currently serving as a Member, Advisory Committee on Dengue and Other Flavivirus Vaccines, Initiative for Vaccine Research, World Health Organization, Geneva. Dr. Edelman has directed the Travelersâ?T Health Clinic at the University of Maryland Medical Center since 1992, and has served as Chairman of the Institutional Review Board, University of Maryland, Baltimore since 2002. Dr. Edelman lists 172 peer-reviewed papers, 71 abstracts and 26 book chapters in his bibliography.

Research Interests

Clinical trials of experimental or licensed vaccines or biologicals in healthy young or elderly volunteers against many infectious diseases. These include emerging vector-borne infections (dengue, malaria, Lyme, Chikungunya), bioterror agents (Botulinum toxin and smallpox), diarrheal diseases, hepatitis B, and seasonal and pandemic influenza. He has conducted research in immunosenescence and vaccines for the elderly (pneumococcus and influenza), and in clinical trials of vaccine adjuvants. He has clinical expertise in travelers' health and travel vaccines, and in bioethics of clinical research and Good Clinical Practices.

Clinical Speciality

Travel Medicine, infectious diseases and public health

Publications

Selected peer-reviewed publications (Research and Reviews), 2004-present

Le T, J Cherry, SJ Chang, MD Knoll, ML Lee, S Barenkamp, D Bernstein, R Edelman, KM Edwards, D Greenberg, W Keitel, J Treanor, JI Ward. "Immune Responses and Antibody Decay after Immunization of Adolescents and Adults with an Acellular Pertussis Vaccine: The APERT Study." Aug 1, 2004, J. Infect. Dis., 190:535-544.

Cherry JD, SJ Chang, D Klein, M Lee, S Barenkamp, D Bernstein, R Edelman, MD Decker, DP Greenberg, W Keitel, J Treanor, JI Ward. "Prevalence of Antibody to Bordetella pertussis Antigens in Serum specimens obtained from 1,793 Adolescents and Adults." Clin Infect Dis 2004 (December 1); 39:1715-18.

KA Kumar, GA Oliveira, R Edelman, E Nardin, V Nussenzweig. "Quantitative Plasmodium Sporozoite neutralization assay (TN-SNA)." J Immunol Methods 2004, Sept. 292 (1-2): 157-164.

Roghmann M, Taylor KL, Gupte A, Zhan M, Johnson JA, Cross A, Edelman R and Fattom A. "Epidemiology of Capsular and Surface Polysaccharide in Staphylococcus aureus Infections Complicated by Bacteraemia." J Hosp Infect. January 2005: 59:27-32.

Tacket CO, Pasetti MF, Edelman R, Howard JA, Streatfield S. "Immunogenicity of recombinant LT delivered orally to humans in transgenic corn." Vaccine, 2004, 22, 4385-4389.

Dowling TC, PA Chavaillaz, DG Young, A Melton-Celss, A O'Brien, C Thuning-Roberson, R Edelman, CO Tacket. "Phase 1 safety and pharmacokinetic study of a chimeric murine-human monoclonal antibody cαStx2 administered intravenously to healthy adult volunteers." Antimicrobial Agents and Chemotherapy. May 2005, 49, No.5, 1808-12.

JI Ward, JD Cherry, S-J Chang, S Partridge, H Lee, J Treanor, D Greenberg, W Keitel, S Barenkamp, DBernstein, R Edelman, K Edwards, D Klein and the APERT Study Group. "Efficacy of an Acellular Pertussis Vaccine AmongAdolescents and Adults." New Engl J Med, October 13, 2005, 353, No. 15, 1555-63.

AP Rapoport, EA Stadtmauer, N Aqui, A Badros, J Cotte, L Chrisley, E Veloso, Z Zheng, S Westphal, R Mair, N Chi, B Ratterree, MF Pochran, S Natt, J Hinkle, C Sickles, D Porter, S Luger, A Sohal, K Ruehle, C Lynch, L Zhang, C Guo, H Fang, W Blackwelder, K Hankey, D Mann, R Edelman, C Frasch, BL Levine, A Cross, and CH June. "Restoration of Immunity in Lymphopenic Individuals with Cancer by Vaccination and Adoptive T Cell Transfer." Nature Medicine, November, 2005, Volume 11, No. 11, 1230-1237.

J.I. Ward, JD Cherry, S-J Chang, S Partridge, W Keitel, K Edwards, M Lee, J Treanor, DP Greenberg, S Barenkamp, D Bernstein, R Edelman, and the APERT study group. "Bordetella Pertussis Infections in Vaccinated and Unvaccinated Adolescents and Adults, as Assessed in a National Prospective Randomized Acellular Pertussis Vaccine Trial (APERT)." Clin Infect Dis, 15 July 2006; 43:151-7.

R Edelman. "Dengue vaccines approach the finish line." Tribute to Ted Woodward, Clin Infect Dis. July, 2007; 45:S56-S60.

Cross AS, Calia FM, Edelman R. "From Rabbits to Humans: The contributions of Dr. Theodore E. Woodward to Tularemia Research." Tribute to Ted Woodward, Clin Infect Dis. July, 2007; 45:S61-S67.

RB Couch, P Winokur, R Brady, R Belshe, WH Chen, TR Cate, B Sigurdardottir, A hoeper, IL Graham, R Edelman, F He, D Nino, J Capellan, FL Ruben. "Safety and Immunogenicity of a New High Dosage Trivalent Influenza Vaccine among Elderly Subjects." Vaccine, October 2007; 25: 7656-7663.

AL Gregson, G Oliveira, CO Watta, JM Calvo-Calle, GB Thorton, E Nardin, R Edelman. "Phase I Trial of an Alhydrogel Adjuvanted Hepatitis B Core virus like Particle Containing Epitopes of Plasmodium falciparum Circumsporozoite Protein." Feb 6, 2008. PLoS ONE. Available online at:http://www.plosone.org/doi/pone.0001556.

R Edelman, J Hombach, "Guidelines for the Clinical Evaluation of Dengue Vaccines in Endemic Areas: Summary of a World Health Organization Steering Committee Report." Vaccine 26 (2008) 4113-4119.

AR Falsey, EE Walsh, M Zambon, J Capellan, S Gravenstein, M Zambon, E Yau, GJ Gorse, R Edelman, FG Hayden, JE McElhaney, KM Neuzil, KL Nichol, AF Simoes, PF Wright, VMP Sales. Comparison of the Safety and Immunogenicity of 2 Respiratory Syncytial Virus (RSV) Vaccines - Non-Adjuvanted Vaccine or Vaccine Adjuvanted with Alum - Given Concomitantly with Influenza Vaccine to High-Risk Elderly Individuals. J Infect Dis., 2008; 198:1317-1326.

Sun W, Cunningham D, Wasserman SS, Perry J, Putnak JR, Eckels KH, Vaughn DW,Thomas SJ, Kanesa-Thasan N, Innis BL, Edelman R. "Phase 2 Clinical Trial of Three Formulations of Tetravalent Live-attenuated Dengue Vaccine in Flavivirus-Naive Adults," Human Vaccines, 2008 May 27: 4 (6) [Epub ahead of print]; 5:1, 33-40; January 2009.

WH Chen, BF Kozlovsky, RB Effros, B Grubeck-Loebenstein, R Edelman, MB Sztein. "Vaccination in the elderly: an immunological perspective." Trends in Immunology (In press)

Recent Book Chapters:

Simon J, Edelman R. "Clinical Evaluation of Adjuvants." In: Immunopotentiators in Modern Vaccines. Schijns EJC and O'Hagan DT (Eds.). Elsevier Academic Press, Amsterdam, pages 319-342, 2006.

R Edelman. "Guidelines for the Clinical Evaluation of Dengue Vaccines in Endemic areas." In: Who Initiative for Vaccine Research (IVR). World Health Organization, Geneva, Switzerland, September 2008. www.who.int/vaccines-documents/ ordering code: WHO/IVB/08.12.

Edelman R, Whitehead SS, Vaughn DW. "Vaccine Strategies to Prevent Dengue." In: New Generation Vaccines, 4th Edition, MM Levine, G Dougan, MF Good, MA Liu, GJ Nable, JP Nataro, and R Rappuoli. (Eds.) Informa healthcare, New York, 2009 (in press).

http://medschool.umaryland.edu/facultyresearchprofile/viewprofile.aspx?id=2688