Durland Fish- Grant
2011
http://projectreporter.nih.gov/project_info_details.cfm?aid=8048445&icde=0
Project Number:
1R21AI088079-01A1
Contact Principal Investigator:
Title:
THE HEALTH BURDEN OF A RECENTLY DISCOVERED BORRELIA SPIROCHETE
Awardee Organization:
YALE UNIVERSITY
Contact PI Information:
Program Official Information:
Name: KRAUSE, PETER JAMES
Email: Click to view contact PI email address
Title:
Name: BREEN, JOSEPH J.
Email: Click to view PO email address
Other PI Information: Profile Exists No Profile
Organization:
Name: YALE UNIVERSITY
City: NEW HAVEN Country: UNITED STATES (US)
Department/ Educational Institution Type:
Congressional District:
PUBLIC HEALTH & PREV MEDICINE
SCHOOLS OF MEDICINE
State Code: CT
District: 03
Other Information:
RFA/PA:
DUNS Number:
043207562
CFDA Code:
855
Study Section:
Clinical Research and Field Studies of Infectious Diseases Study Section (CRFS)
Project Start Date:
1-SEP-2011
Project End Date:
31-AUG-2013
Fiscal Year: 2011
Award Notice Date: 19-AUG-2011
Budget Start Date:
1-SEP-2011
Budget End Date:
31-AUG-2012
Administering Institutes or Centers:
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Project Funding Information for 2011:
Total Funding: $309,310
Year
Funding IC
FY Total Cost by IC
2011
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
$309,310
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Similar Projects
THE HEALTH BURDEN OF A RECENTLY DISCOVERED BORRELIA SPIROCHETE
KRAUSE, PETER JAMES et al.
YALE UNIVERSITY
2011
NIAID
NIAID
$309,310
Page 1 of 1
Project Number:
1R21AI088079-01A1
Contact Principal Investigator:
Title:
THE HEALTH BURDEN OF A RECENTLY DISCOVERED BORRELIA SPIROCHETE
Awardee Organization:
YALE UNIVERSITY
Project Number:
1R21AI088079-01A1
Contact Principal Investigator:
Title:
THE HEALTH BURDEN OF A RECENTLY DISCOVERED BORRELIA SPIROCHETE
Awardee Organization:
YALE UNIVERSITY
Abstract Text:
DESCRIPTION (provided by applicant): We have found a new Borrelia spirochete that causes persistent infection in laboratory mice and is widely distributed in field populations of Ixodes tick vectors of Lyme disease throughout the United States. Preliminary genetic and antigen analysis indicates that this organism is a member of a closely related group of relapsing fever spirochetes and was originally described as Borrelia miyamotoi in Japan.
Recent investigations provide convincing evidence that this spirochete causes human disease in Russia where the percentages of B. miyamotoi-infected Ixodes ticks are similar to those in the northeastern United States. Some of these patients experienced prolonged, relapsing illness. Basic information is lacking regarding genetic and antigenic characteristics of this novel spirochete and diagnostic tools are not yet developed for clinical use.
Although only a few human cases of infection with B. miyamotoi are currently recognized, we suspect that cases may exist elsewhere within its broad geographic distribution and particularly in the northeastern United States where Lyme disease is hyperendemic. Accordingly, we propose to investigate the antigenic relationship between B. miyamotoi and other Borrelia species in order to develop improved diagnostic methods and to compare the frequency and clinical manifestations of B. miyamotoi infection with those of Borrelia burgdorferi in the Northeast.
Such information is urgently needed because of the high level of human exposure to bites from ticks potentially infected with B. miyamotoi in Lyme endemic regions and because infection cannot be detected with the same laboratory procedures used to diagnose Lyme disease.
Because B. miyamotoi belongs to the relapsing fever group of spirochetes and causes persistent illness with relapsing fever symptoms, it is possible that some prolonged episodes of illness attributed to Lyme disease and designated as "chronic Lyme disease" are due to B. miyamotoi infection.
PUBLIC HEALTH RELEVANCE: A new form of I scapularis-borne Borrelia spirochete (B. miyamotoi) is widely distributed in field populations of ticks in the United States but basic information is lacking regarding its antigenic characteristics, diagnostic tools are not yet well developed, and it is unclear whether cases exist beyond Russia where the first few human cases have been described. We propose to investigate the antigenic relationship between this spirochete and other Borrelia species in order to develop improved diagnostic methods, and to compare the seroprevalence and clinical manifestations of B. miyamotoi infection with those of Borrelia burgdorferi.
Such information is urgently needed because the organism is found in the same vector tick and mouse reservoir of Borrelia burgdorferi in Lyme endemic regions of the United States and because it is possible that some prolonged episodes of illness attributed to Lyme disease may actually be due to infection with this B. miyamotoi organism.
Public Health Relevance Statement:
A new form of I scapularis-borne Borrelia spirochete (B. miyamotoi) is widely distributed in field populations of ticks in the United States but basic information is lacking regarding its antigenic characteristics, diagnostic tools are not yet well developed, and it is unclear whether cases exist beyond Russia where the first few human cases have been described. We propose to investigate the antigenic relationship between this spirochete and other Borrelia species in order to develop improved diagnostic methods, and to compare the seroprevalence and clinical manifestations of B. miyamotoi infection with those of Borrelia burgdorferi. Such information is urgently needed because the organism is found in the same vector tick and mouse reservoir of Borrelia burgdorferi in Lyme endemic regions of the United States and because it is possible that some prolonged episodes of illness attributed to Lyme disease may actually be due to infection with this B. miyamotoi organism.
Project Terms:
http://projectreporter.nih.gov/project_info_description.cfm?aid=8048445&icde=0