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617-636-8498
Linden T. Hu, MD
Titles
Associate Professor of Medicine
Education Background
Undergraduate: Brown University 1983-1987
Medical School: Brown University School of Medicine 1986-1990
Residency: St. Elizabeth's Medical Center, Boston, MA 1990-1993
Fellowship: Infectious Disease, Tufts Medical Center, Boston, MA 1993-1997
Research Interests
Host-pathogen interactions in the development of Lyme arthritis. Mechanisms of environmental adaptations by Borrelia burgdorferi
Clinical Interests
Vector-borne infections
Selected Publications
Hu. L.T., Update on Lyme arthritis, Infect. Dis. Clin. N.A., 2005, 19(4):947-61.
Scheckelhoff, M.R., Telford, S.R., and L.T. Hu, Protective efficacy of an oral vaccine to reduce carriage of Borrelia burgdorferi (strain N40) in mouse and tick reservoirs, 2006, Vaccine, 24:1949-1957
Behera, A.K., Hildebrand, E., Bronson, R., Perides, G. and L.T. Hu, MyD88 deficiency results in tissue specific changes in cytokine induction and inflammation in Borrelia burgdorferi infected mice that are IL-18 independent, 2006, Infect Immun, 74:1462-70.
Behera, A.K., Hildebrand, E., Coburn, J., Uematsu, S, Akira, S, and L.T. Hu, Identification of a TLR independent pathway for Borrelia burgdorferi induced expression of matrix metalloproteinases and inflammatory mediators through binding to integrin a3b1, J Immunol, 2006, 177:657-64.
Behera, A.K., Hildebrand, E., Szafranski, J., Hung, H.H., Grodzinsky,A.J., Lafyatis, R., Koch, A.E., Kalish, R., Perides, G., Steere, A.C. and L.T. Hu, Role of aggrecanase-1 in Lyme arthritis, Arthr Rheum, 2006, 54:3319-29.
Medrano, M., Ding, YP, Wang, XG, Lu, P, Coburn, JL, and LT Hu, Regulators of expression of the oligopeptide permease A proteins of Borrelia burgdorferi, J. Bacteriol, 2007, 189:2653-9.
Shin, O.S., Behera, A.K., Bronson, R., and L.T. Hu, Role of Novel Protein Kinase C (PKC) isoforms in Lyme Arthritis, Cell. Microbiol, 2007, 9(8):1987-96.
Klempner, M.S., Unnasch, T.R., and L.T. Hu, Taking a bite out of vector-borne diseases, New Engl. J. Med., 356:2567-9.
Scheckelhoff, M.R., Telford, S.R., Wesley, M. and L.T. Hu, Borrelia burgdorferi intercepts host hormonal signals to regulate expression of outer surface protein A, Proc. Natl. Acad. Sci, 2007, 104(17):7247-52
Behera, A., Durand, E., Cugini, C., Hildebrand, E., Hu, L.T. and J.L. Coburn, Borrelia burgdorferi BBB07 interaction with integrin a3b1 stimulates production of pro-inflammatory mediators in primary human chondrocytes, Cell Microbiol., 2007, in press
http://www.tuftsmedicalcenter.org/ourservices/infectiousdiseases/IDFacultyLindenTHu