Capecitabine

Capecitabine

500mg/tab

Dosage - Range: 4 to 6 tabs /day

MONOTHERAPY:

-RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period

Female average - 1.6 m2

Female

2500 mg x 1.6 = 4000 mg / day = 2000 mg 2xday = 4 tabs (500mg/tab) 2x day = 8 tabs a day

Tablets should be swallowed whole with water within 30 minutes after a meal.

Brands:

Xeloda

Caxeta

Capvex - P120/tab (Mercury)

Xelocel - P85/tab (Medical Infinity; Estela; 09992244639)

Capecitabine is an antineoplastic (anti-cancer) medication used to treat breast cancer and colon or rectum cancer that has spread to other parts of the body. Common side effects of Xeloda include:

• • severe nausea or vomiting (may be severe),

  • stomach pain or upset,

  • loss of appetite,

  • constipation,

  • tiredness,

  • weakness,

  • back/joint/muscle pain,

  • headache,

  • dizziness,

  • trouble sleeping,

  • skin darkening,

  • skin rash,

  • dry/itchy skin, or

  • numbness or tingling in your hands or feet.

https://www.rxlist.com/xeloda-side-effects-drug-center.htm

Capecitabine

•Adverse Drug Reactions: overall, oral capecitabine is less toxic than the IV form, 5-FU

• Hand-and-foot syndrome

• GI events

• Hepatotoxicity

• Cardiotoxicity

• Box warning: increased risk of bleeding and death when taken with coumarin-derived anticoagulants

https://www.slideshare.net/SandeepkumarBalabbig/oral-chemotherapy

ROJ@20may7