Modulation of TRP activity by estrogens

The Transient Receptor Potential (TRP) family of ionic channels is activated by a wide variety of environmental physico-chemical stimuli acting as molecular transducers and integrators. Among them, some steroid molecules are involved in the modulation of TRP channel activity. Furthermore, TRPV1 is estrogen modulated by a rapid and non genomic pathway and plays a crucial role in the defense of against heat-induced oxidative stress.  In this context, thermoTRP channels are widely expressed in several tissues of brain and gonads and poorly studied with respect to their functions in neuroendocrine excitability and reproductive phenomena.  We study TRPV1 related estrogen’s mechanism of action. This will be addressed   by registering the biophysical modification of TRPV1 activity as TRP channels in ROS induced cell death processes. This wills demonstrate the locally produced estrogen modulation of TRPV1 activity as a protective tissue mechanism in response to oxidative stress. 

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