Ophthalmic drugs
Ophthalmic drugs
Learning objectives: Learn about the drugs that are instilled or applied on eyes, their classification and mechanism of action
Anatomy of the eye
Anatomy of the eye
Part Function/Description
Iris Colorful part that controls light entry
Cornea Clear outer part directing images into the eye
Lens Focuses images onto the retina
Pupil Dark center of the eye
Retina Lining at the back of the eye
Fovea Part of the retina containing only cones
Cones are sensitive to color and detail, while rods are sensitive to low light.
Mnemonic for cones: 'You see these when you pass an accident on the road.'
Mnemonic for rods: 'What you use when you go fishing.'
Ganglion cells receive signals from bipolar cells, crucial for transmitting visual information to the brain.
Bipolar cells first receive messages from rods and cones, acting as intermediaries.
Mnemonic for ganglion cells: 'A pride of lions' and for bipolar cells: 'A bear in cold climates.'
This theory states that color perception is controlled by opposing pairs: red-green, blue-yellow.
Mnemonic: 'Cones in a boxing ring with one knocked out.'
Only one color from each pair can be perceived at a time.
This theory posits that color vision is based on three types of cones sensitive to red, green, and blue.
Mnemonic: 'Tricycles and a blender' to remember the blending of colors.
The combination of signals from these cones allows for the perception of a wide range of colors.
[Reference: https://quizlet.com/study-guides/mnemonic-devices-for-eye-and-ear-anatomy-17886793-886d-406e-9988-7e9daf17f7db]
Practice questions
Which drug is used in psoriatic arthritis?
a) Methotrexate
b) Metronidazole
c) Ciprofloxacin
d) Fligrastim
Answer: a) Methotrexate
Wilson & Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry.
Edited by Charles Owens Wilson, Ole Gisvold, John H. Block, John M. Beale; Lippincott Williams & Wilkins, 2003
An Introduction to Medicinal Chemistry,
Graham L. Patrick
4th Edition, 2009, Oxford University Press
FOYE’S PRINCIPLES OF MEDICINAL CHEMISTRY 6TH EDITION
Medicinal Chemistry and Drug Design