Dermatological drugs and drugs applied on skin
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Objective:
This page enlists some dermatological drugs and drugs applied on skin and provide the the reader an idea on the physiology of skin, drugs that are applied on skin and how these drugs and absorbed and exert their action.
Key words:
Dermatology, skin, topical application, drug-drug interactions
Advanced drug discovery technologies
Pharmacological profiling is central to translating promising targets and compounds into credible drug candidates. Within this role the Research Officer will design and execute in vitro and cellular pharmacology assays to characterise compound potency, selectivity, and mechanism of action, generating decision-quality data necessary to progress drug discovery candidates through the THerapeutic INnovation for Kids (THINK) pipeline to commercialization and clinical trials.
Advanced drug discovery is carried out employing technologies such as HTRF, AlphaScreen, SPR and other biophysical techniques to measure receptor binding. Cell based models to measure target engagement such as CETSA, in cell phosphorylation etc.
In the RNA Therapeutics in Cancer, molecular cloning techniques (restriction cloning, Gibson assembly, Golden Gate, or similar); mammalian cell culture (passage, transfection, and maintenance); RNA handling, extraction, and quality control (Bioanalyzer/TapeStation, Qubit, gel electrophoresis); analysing single-cell genomic datasets such as scRNA-seq, scATAC-seq or multiome data are employed.
For the drug development related to proteins, molecular biology experiments, including cloning, PCR, and plasmid construction, protein production/expression, protein expression in heterologous expression systems such as yeast cells, purification, affinity evaluation and functional assays , recombinant protein expression and purification, experiments with microfluidics, such as microfluidic chip fabrication, protein engineering with microfluidics for translational applications
References
1. Jayasinghe, R., Kovoor, P. (2002). Drugs and the QTc interval. Australian Prescriber-an independent review. 25(3): 63-65. DOI: 10.18773/austprescr.2002.058.
Disclaimer
Most of the information in this page are collected from Google AI Overview. These are for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes. Learn more
Practice questions
Treatment for seborrheic dermatitis [OPRA recall Nov 2025]
a. Selenium
b. Ketoconazole
c. Coal tar
d. all
Answer The correct answer is d. all
Seborrheic dermatitis is a common, chronic inflammatory skin condition that causes scaly, itchy patches and stubborn dandruff on oily areas of the body, such as the scalp, face, and chest.
Selenium sulfide, ketoconazole, and coal tar are all recognized medical treatments for seborrheic dermatitis.
Treatment Breakdown
Selenium sulfide: Reduces yeast growth, scaling, and cell turnover.
Ketoconazole: Targets the underlying fungal (Malassezia) overgrowth and reduces inflammation.
Coal tar: Slows rapid skin cell growth and helps clear heavy scaling and crusts.
Treatment for Vaginal thrush [OPRA recall Nov 2025]
a. Clotrimazole 500 mg once topical
b.Fluconazole oral
c. both a and b
d. none
Answer The correct answer is d. all
Vaginal thrush is easily treated using over-the-counter antifungal medications like oral capsules, vaginal pessaries, or creams.Common Treatment OptionsOral Capsules: A single dose of fluconazole (such as a 150 mg tablet) taken by mouth treats the infection from the inside.Vaginal Pessaries: A small tablet or soft capsule inserted into the vagina using an applicator, which dissolves over one to six nights.Internal and External Creams: Inserted with an applicator for internal treatment, often paired with an external cream to soothe itching and redness on the vulva. Combination packs like the TerryWhite Chemmart Duo Thrush Treatment provide both internal and external relief.
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