Advanced drug discovery technologies

Objective:

This page enlists some advanced drug discovery technologies  and provide the the reader an idea on how new drug discoveries are carried out.

Key words:

Advanced drug discovery technologies, drug-receptor interactions, drug-drug interactions

Advanced drug discovery technologies

Pharmacological profiling is central to translating promising targets and compounds into credible drug candidates. Within this role the Research Officer will design and execute in vitro and cellular pharmacology assays to characterise compound potency, selectivity, and mechanism of action, generating decision-quality data necessary to progress drug discovery candidates through the THerapeutic INnovation for Kids (THINK) pipeline to commercialization and clinical trials. 

Advanced drug discovery is carried out employing technologies such as HTRF, AlphaScreen, SPR and other biophysical techniques to measure receptor binding. Cell based models to measure target engagement such as CETSA, in cell phosphorylation etc. 

In the RNA Therapeutics in Cancer, molecular cloning techniques (restriction cloning, Gibson assembly, Golden Gate, or similar);  mammalian cell culture (passage, transfection, and maintenance); RNA handling, extraction, and quality control (Bioanalyzer/TapeStation, Qubit, gel electrophoresis); analysing single-cell genomic datasets such as scRNA-seq, scATAC-seq or multiome data  are employed.

References

1. Jayasinghe, R., Kovoor, P. (2002). Drugs and the QTc interval. Australian Prescriber-an independent review. 25(3): 63-65. DOI: 10.18773/austprescr.2002.058.

Disclaimer

Most of the information in this page are collected from Google AI Overview. These are for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes. Learn more