Antidotes and drug-drug interactions

Objective:

This page enlists antidotes and some drug-drug interactions and provide the the reader an idea on co-administration of which drugs to be cautious.

Key words:

Antidote, drug-drug interactions, inducer, inhibitor

Antidotes of drugs

Opioids (Morphine, Heroin, Oxycodone, Fentanyl) : Naloxone

Benzodiazepines (Diazepam, Lorazepam, Alprazolam): Flumazenil

Acetaminophen (Paracetamol): N-Acetylcysteine (NAC)

Anticholinergics (Atropine, TCAs, Diphenhydramine): Physostigmine

Beta Blockers (Metoprolol, Atenolol, Propranolol): Glucagon

Calcium Channel Blockers (Amlodipine, Verapamil, Diltiazem): Calcium Gluconate

Iron: Deferoxamine

Carbon Monoxide (CO): 100% Oxygen

Organophosphates (Pesticides, Nerve Agents): Atropine + Pralidoxime (2-PAM)

Cyanide (CN): Hydroxocobalamin or Sodium Thiosulfate

Drug drug interaction

Drug interaction with antacid, H2 blocker and proton pump inhibitors.

Helpful video [Clear concept]

Drug induced conditions

References

1. Antwi, C. A., Amisigo, C. M., Adjimani, J. P., & Gwira, T. M. (2019). In vitro activity and mode of action of phenolic compounds on Leishmania donovani. PLoS neglected tropical diseases, 13(2), e0007206.

2. Yang, D., Huang, Z., Xing, B., Jin, W., Yan, X., Guo, Z., & Liang, Z. (2016). Regulation of folic acid on phenolic acids production in Salvia miltiorrhiza hairy roots. Plant Cell, Tissue and Organ Culture (PCTOC), 127, 175-185.

3. Mykhailenko, O., Kovalyov, V., Kovalyov, S., & Krechun, A. (2017). Isoflavonoids from the rhizomes of Iris hungarica and antibacterial activity of the dry rhizomes extract. Ars Pharmaceutica (Internet), 58(1), 39-45.

Disclaimer

Most of the information in this page are collected from Google AI Overview. These are for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes. Learn more