Drugs act on central nervous system
Drugs act on central nervous system
Learning objectives: Learn about the drugs that act on central nervous system, their classification and mechanism of action
Antibacterial agents
Antibacterial Substances or antimicrobial chemotherapeutic agents are chemical substances used in the treatment of infectious diseases caused by pathogenic microorganisms. Their mode of action is to interfere with microbial metabolism; thereby producing a bacteriostatic or bacteriocidal effect on the microorganisms, without producing a like effect on the host cells.
Example:
Bacterial 30 s Ribosomal subunit inhibitors: Tetracyclines
Bacterial 50 s Ribosomal subunit inhibitors: Macrolides, Chloramphenicol, Erythromycins,
Bacterial cell wall inhibitors: Penicillins, Carbapenems, Cephalosporines
Folic Acid synthesis inhibitors: Sulfonilamides
Antibiotics are synthesized and secreted by some true bacteria, actinomycetes (Soil bacteria), and fungi. These molecules are designed in nature to inhibit or prevent the growth of other microorganisms in the environment. Today, antibiotics have been designed or modified based on this basic principle. There are other synthetic drugs produced through drug research that are capable of inhibiting bacterial growth.
Pathologic microorganism-Microorganisms in a certain amount that can produce diseases are called pathologic microorganism or pathogenic microorganism.
Anti-organism- Substances that are active against pathogenic microorganism are called anti-organism.
Causative microorganism- A specific microorganism which can causes a specific disease is called causative microorganism for that disease. For example-Salmonela typhi is the causative microorganism for typhoid, Mycobacterium Leprae for leprosy, Mycobacterium tubercoli for tuberculosis.
Wilson & Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry.
Edited by Charles Owens Wilson, Ole Gisvold, John H. Block, John M. Beale; Lippincott Williams & Wilkins, 2003
An Introduction to Medicinal Chemistry,
Graham L. Patrick
4th Edition, 2009, Oxford University Press
FOYE’S PRINCIPLES OF MEDICINAL CHEMISTRY 6TH EDITION
Medicinal Chemistry and Drug Design