Ear, nose and throat drugs
Ear, nose and throat drugs
Learning objectives: Learn about the drugs that are instilled or applied on Ear, nose and throat drugs, their classification and mechanism of action.
Parts of the ear
Parts of the ear
Pinna and Auditory Canal
The pinna is the visible part of the ear; mnemonic: visualize pins sticking into it.
The auditory canal channels sound waves to the eardrum; imagine empty cans connected together.
Eardrum and Ossicles
The eardrum (tympanic membrane) vibrates in response to sound; mnemonic: think of a drum causing panic.
The ossicles (hammer, anvil, stapes) amplify sound vibrations before they reach the cochlea.
Cochlea and Basilar Membrane
The cochlea converts sound vibrations into neural signals; it is filled with fluid.
The basilar membrane contains hair cells (cilia) that respond to sound frequencies.
Inner ear: https://my.clevelandclinic.org/health/body/24340-inner-ear]
Anatomy of the ear
Anatomy of the Ear
Auditory Canal
The auditory canal is the passage through which sound waves travel after entering the ear.
Visualize the auditory canal as a series of empty cans connected together, symbolizing the pathway of sound.
The canal plays a crucial role in directing sound waves towards the eardrum.
Eardrum (Tympanic Membrane)
The eardrum, also known as the tympanic membrane, vibrates in response to sound waves.
The mnemonic 'drum' helps to remember its function, as drums produce loud sounds that can cause panic.
It serves as a barrier between the outer ear and the middle ear, crucial for sound transmission.
Ossicles: Hammer, Anvil, and Stirrup
The ossicles consist of three tiny bones: Hammer (Malleus), Anvil (Incus), and Stirrup (Stapes).
The order of sound transmission is Hammer → Anvil → Stirrup (H-A-S).
These bones amplify sound vibrations from the eardrum to the inner ear.
Cochlea and Oval Window
The cochlea is a spiral-shaped organ filled with fluid, essential for converting sound vibrations into neural signals.
The oval window is the membrane-covered opening that the stirrup connects to, transmitting vibrations into the cochlea.
Visualize the cochlea as a 'coke' container, where fluid movement is akin to pouring soda.
Basilar Membrane and Cilia
The basilar membrane runs through the cochlea and contains hair cells (cilia) that respond to fluid vibrations.
The mnemonic 'bass swimming' helps to remember the function of the basilar membrane.
Cilia move in response to sound vibrations, playing a critical role in hearing by converting mechanical energy into electrical signals.
Inner ear: https://my.clevelandclinic.org/health/body/24340-inner-ear]
Practice questions
Which drug is used in psoriatic arthritis?
a) Methotrexate
b) Metronidazole
c) Ciprofloxacin
d) Fligrastim
Answer: a) Methotrexate
References
Lippincott Illustrated Reviews: Pharmacology
Edition: 8
Karen Whalen; Lippincott Williams & Wilkins, 2022
Wilson & Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry.
Edited by Charles Owens Wilson, Ole Gisvold, John H. Block, John M. Beale; Lippincott Williams & Wilkins, 2003
An Introduction to Medicinal Chemistry,
Graham L. Patrick
4th Edition, 2009, Oxford University Press
FOYE’S PRINCIPLES OF MEDICINAL CHEMISTRY 6TH EDITION
Medicinal Chemistry and Drug Design