Various measures have been taken to remove some of the “metagaming” strategies people employ. If you don’t really find yourself doing that, you’ll probably never notice the changes!
For example, Shor's stone guard patrol location was moved to prevent forcing the guard to follow you through the mine and killing the spiders for you.
When on horseback, you deal much less damage (without high-level perks) and take more damage. Stick to using your horse for travel or storage.