Methodology

Features and Thresholds

The features used in Vax-ELAN include cellular localization, secretory/non-secretory protein, stability, cleavage sites, adhesion property, CTL epitope prediction, MHC class-I binding, transmembrane helix prediction, essentiality, virulence, molecular weight, non-homology with host proteins, etc.

Methodology - Features and Thresholds.xlsx

List of tools used for extraction of features along with their cut-off values and justification

Strategies Used to Shortlist Vaccine Targets

Vax-ELAN has provision to scan protein sequences (or proteomes) using multiple strategies

Schematic representation of different strategies with relevant characteristics (features) used in Vax-Elan