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Section 1 : T. cruzi epitopes and receptors docking
We used HPEPDOCK (Zhou et al., 2018) to carry out protein-peptide docking. Here, the protein is one of the receptors listed in Table 1 and the peptides are the epitopes shortlisted through Vax-ELAN.
References
1. Zhou P, Jin B, Li H, Huang S-Y.* HPEPDOCK: a web server for blind peptide-protein docking based on a hierarchical algorithm. Nucleic Acids Research, doi: 10.1093/nar/gky357, 2018.
2. Herrera, E. M., Ming, M., Ortega-Barria, E., & Pereira, M. E. (1994). Mediation of Trypanosoma cruzi invasion by heparan sulfate receptors on host cells and penetrin counter-receptors on the trypanosomes. Molecular and biochemical parasitology, 65(1), 73-83.
3. Cremaschi, G., Fernández, M. M., Gorelik, G., Goin, J. C., Fossati, C. A., Zwirner, N. W., & Malchiodi, E. L. (2004). Modulatory effects on myocardial physiology induced by an anti-Trypanosoma cruzi monoclonal antibody involve recognition of major antigenic epitopes from β1-adrenergic and M2-muscarinic cholinergic receptors without requiring receptor cross-linking. Journal of neuroimmunology, 153(1-2), 99-107.
4. Ferrari, I., Levin, M. J., Wallukat, G., Elies, R., Lebesgue, D., Chiale, P., ... & Hoebeke, J. (1995). Molecular mimicry between the immunodominant ribosomal protein P0 of Trypanosoma cruzi and a functional epitope on the human beta 1-adrenergic receptor. The Journal of experimental medicine, 182(1), 59-65.
Section 2: Epitope and Innate Immunity Receptor
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