Embedded Files
Within Strategy 3, a total of 6 filters were incorporated to screen the proteins of
Within Strategy 3, a total of 6 filters were incorporated to screen the proteins of
T.cruzi CL Brener.
T.cruzi CL Brener.
It included the random filtering of proteins (not in a sequential manner) to find out eligible protein candidates then selecting them to construct a vaccine.
It included the random filtering of proteins (not in a sequential manner) to find out eligible protein candidates then selecting them to construct a vaccine.
Flowchart representing the input of 19602 proteins into random filter and final retrieval of 100 proteins.
Flowchart representing the input of 19602 proteins into random filter and final retrieval of 100 proteins.
Following files contains python notebook which was used to filter the data, and their successive output at each level of filtering. It includes random order of filters applied via strategy 1, It resulted into same output.
Top 100 proteins retrieved by Strategy-3
Top 100 proteins retrieved by Strategy-3
Top-100_Strategy-3.xlsxTop 8 unique proteins:-
Top 8 unique proteins:-
XP_809166.1 mucin-associated surface protein (MASP) [Trypanosoma cruzi strain CL Brener]
XP_816522.1 mucin TcMUCII [Trypanosoma cruzi strain CL Brener]
XP_815016.1 90 kDa surface protein [Trypanosoma cruzi strain CL Brener]
XP_818708.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
XP_821916.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_804513.1 dispersed gene family protein 1 (DGF-1), partial [Trypanosoma cruzi strain CL Brener]
XP_816111.1 subtilisin-like serine peptidase [Trypanosoma cruzi strain CL Brener]
XP_806816.1 DnaJ chaperone protein [Trypanosoma cruzi strain CL Brener]
Strategy-3 vs Strategy-1
Strategy-3 vs Strategy-1
Intersection of proteins in Strategy-1 and Strategy-3
Intersection of proteins in Strategy-1 and Strategy-3
XP_809166.1 mucin-associated surface protein (MASP) [Trypanosoma cruzi strain CL Brener]
XP_816522.1 mucin TcMUCII [Trypanosoma cruzi strain CL Brener]
XP_815016.1 90 kDa surface protein [Trypanosoma cruzi strain CL Brener]
XP_818708.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
XP_821916.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_804513.1 dispersed gene family protein 1 (DGF-1), partial [Trypanosoma cruzi strain CL Brener]
XP_816111.1 subtilisin-like serine peptidase [Trypanosoma cruzi strain CL Brener]
XP_806816.1 DnaJ chaperone protein [Trypanosoma cruzi strain CL Brener]
Union of proteins in Strategy-3 and Strategy-1:-
Union of proteins in Strategy-3 and Strategy-1:-
Strategy-3:-
XP_809166.1 mucin-associated surface protein (MASP) [Trypanosoma cruzi strain CL Brener]
XP_816522.1 mucin TcMUCII [Trypanosoma cruzi strain CL Brener]
XP_815016.1 90 kDa surface protein [Trypanosoma cruzi strain CL Brener]
XP_818708.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
XP_821916.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_804513.1 dispersed gene family protein 1 (DGF-1), partial [Trypanosoma cruzi strain CL Brener]
XP_816111.1 subtilisin-like serine peptidase [Trypanosoma cruzi strain CL Brener]
XP_806816.1 DnaJ chaperone protein [Trypanosoma cruzi strain CL Brener]
Strategy-1:-
XP_809166.1 mucin-associated surface protein (MASP) [Trypanosoma cruzi strain CL Brener]
XP_816522.1 mucin TcMUCII [Trypanosoma cruzi strain CL Brener]
XP_815016.1 90 kDa surface protein [Trypanosoma cruzi strain CL Brener]
XP_818708.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
XP_821916.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_804513.1 dispersed gene family protein 1 (DGF-1), partial [Trypanosoma cruzi strain CL Brener]
XP_816111.1 subtilisin-like serine peptidase [Trypanosoma cruzi strain CL Brener]
XP_806816.1 DnaJ chaperone protein [Trypanosoma cruzi strain CL Brener]
Strategy-3 vs Strategy-2
Strategy-3 vs Strategy-2
No intersection of proteins were found upon filtering of proteins via Strategy-3 and Strategy-2.
Union of proteins in Strategy-3 and Strategy-2:-
Union of proteins in Strategy-3 and Strategy-2:-
Strategy-3:-
XP_809166.1 mucin-associated surface protein (MASP) [Trypanosoma cruzi strain CL Brener]
XP_816522.1 mucin TcMUCII [Trypanosoma cruzi strain CL Brener]
XP_815016.1 90 kDa surface protein [Trypanosoma cruzi strain CL Brener]
XP_818708.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
XP_821916.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_804513.1 dispersed gene family protein 1 (DGF-1), partial [Trypanosoma cruzi strain CL Brener]
XP_816111.1 subtilisin-like serine peptidase [Trypanosoma cruzi strain CL Brener]
XP_806816.1 DnaJ chaperone protein [Trypanosoma cruzi strain CL Brener]
Strategy-2:-
XP_809166.1 mucin-associated surface protein (MASP) [Trypanosoma cruzi strain CL Brener]
XP_811700.1 mucin TcMUCII [Trypanosoma cruzi strain CL Brener]
XP_822020.1 90 kDa surface protein [Trypanosoma cruzi strain CL Brener]
XP_804447.1 ubiquitin-conjugating enzyme E2 [Trypanosoma cruzi strain CL Brener]
XP_807999.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_806523.1 IgE-dependent histamine-releasing factor [Trypanosoma cruzi strain CL Brener]
XP_808372.1 small nuclear ribonucleoprotein Sm-E [Trypanosoma cruzi strain CL Brener]
XP_818708.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
Strategy-3 vs Strategy-4
Strategy-3 vs Strategy-4
No intersection of proteins were found upon filtering of proteins via Strategy-3 and Strategy-4.
Union of proteins in Strategy-3 and Strategy-4:-
Union of proteins in Strategy-3 and Strategy-4:-
Strategy-3:-
XP_809166.1 mucin-associated surface protein (MASP) [Trypanosoma cruzi strain CL Brener]
XP_816522.1 mucin TcMUCII [Trypanosoma cruzi strain CL Brener]
XP_815016.1 90 kDa surface protein [Trypanosoma cruzi strain CL Brener]
XP_818708.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
XP_821916.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_804513.1 dispersed gene family protein 1 (DGF-1), partial [Trypanosoma cruzi strain CL Brener]
XP_816111.1 subtilisin-like serine peptidase [Trypanosoma cruzi strain CL Brener]
XP_806816.1 DnaJ chaperone protein [Trypanosoma cruzi strain CL Brener]
Strategy-4:-
XP_816052.1 phosphate-repressible phosphate permease [Trypanosoma cruzi strain CL Brener]
XP_807493.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_803296.1 dispersed gene family protein 1 (DGF-1), partial [Trypanosoma cruzi strain CL Brener]
XP_822017.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
XP_819804.1 nucleoside transporter-like [Trypanosoma cruzi strain CL Brener]
XP_820852.1 serine/threonine protein kinase [Trypanosoma cruzi strain CL Brener]
XP_815460.1 receptor-type adenylate cyclase, partial [Trypanosoma cruzi strain CL Brener]
XP_812509.1 UDP-N-acetylglucosamine--dolichyl-phosphate n- acetylglucosaminephosphotransferase [Trypanosoma cruzi CL Brener]
Strategy-3 vs Strategy-5
Strategy-3 vs Strategy-5
No intersection of proteins were found upon filtering of proteins via Strategy-3 and Strategy-5.
Union of proteins in Strategy-3 and Strategy-5:-
Union of proteins in Strategy-3 and Strategy-5:-
Strategy-3:-
XP_809166.1 mucin-associated surface protein (MASP) [Trypanosoma cruzi strain CL Brener]
XP_816522.1 mucin TcMUCII [Trypanosoma cruzi strain CL Brener]
XP_815016.1 90 kDa surface protein [Trypanosoma cruzi strain CL Brener]
XP_818708.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
XP_821916.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_804513.1 dispersed gene family protein 1 (DGF-1), partial [Trypanosoma cruzi strain CL Brener]
XP_816111.1 subtilisin-like serine peptidase [Trypanosoma cruzi strain CL Brener]
XP_806816.1 DnaJ chaperone protein [Trypanosoma cruzi strain CL Brener]
Strategy-5:-
XP_809117.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_821990.1 mucin-associated surface protein (MASP [Trypanosoma cruzi strain CL Brener]
RNC42421.1 mucin TcMUCII [Trypanosoma cruzi]
XP_803883.1 GP85-like protein, partial [Trypanosoma cruzi strain CL Brener]
AAL90889.1 Tcc1j12.3 [Trypanosoma cruzi]
XP_809960.1 trans-sialidase [Trypanosoma cruzi strain CL brener]
XP_808931.1 mucin TcMUCIII {Trypanosoma cruzi strain CL Brener]
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