Embedded Files
Within Strategy 2, a total of 6 filters were incorporated to screen the proteins of
Within Strategy 2, a total of 6 filters were incorporated to screen the proteins of
T. cruzi CL Brener.
T. cruzi CL Brener.
It includes protein filtered through the same 5 filters without subcellular localization and subcellular localization score filters. An extra filter IC50 was also added at last to take this strategy at next level.
It includes protein filtered through the same 5 filters without subcellular localization and subcellular localization score filters. An extra filter IC50 was also added at last to take this strategy at next level.
Flowchart representing the filters in a sequential order with number of proteins filtered mentioned in brackets.
The files in sequence of data obtained ,after each filter was run on the 19,602 proteins.
The files in sequence of data obtained ,after each filter was run on the 19,602 proteins.
Following file contains python script which filters the data, and their successive output at each level of filtering. filter 1 denotes"Non Homology Analysis", filter 2 denotes "Stability Analysis". Additionally, the last excel file, filter 6 comprises of the final file which is the output of the filtering process.
Top 100 proteins retrieved by Strategy-2
Top 100 proteins retrieved by Strategy-2
Top-100_Strategy-2.xlsxTop 8 unique proteins:-
Top 8 unique proteins:-
XP_809166.1 mucin-associated surface protein (MASP) [Trypanosoma cruzi strain CL Brener]
XP_811700.1 mucin TcMUCII [Trypanosoma cruzi strain CL Brener]
XP_822020.1 90 kDa surface protein [Trypanosoma cruzi strain CL Brener]
XP_804447.1 ubiquitin-conjugating enzyme E2 [Trypanosoma cruzi strain CL Brener]
XP_807999.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_806523.1 IgE-dependent histamine-releasing factor [Trypanosoma cruzi strain CL Brener]
XP_808372.1 small nuclear ribonucleoprotein Sm-E [Trypanosoma cruzi strain CL Brener]
XP_818708.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
Strategy-2 vs Strategy-1
Strategy-2 vs Strategy-1
Intersection of proteins in Strategy-2 and Strategy-1:-
Intersection of proteins in Strategy-2 and Strategy-1:-
XP_809166.1 mucin-associated surface protein (MASP) [Trypanosoma cruzi strain CL Brener]
XP_818708.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
Union of proteins in Strategy-2 and Strategy-1:-
Union of proteins in Strategy-2 and Strategy-1:-
Strategy-2:-
XP_809166.1 mucin-associated surface protein (MASP) [Trypanosoma cruzi strain CL Brener]
XP_811700.1 mucin TcMUCII [Trypanosoma cruzi strain CL Brener]
XP_822020.1 90 kDa surface protein [Trypanosoma cruzi strain CL Brener]
XP_804447.1 ubiquitin-conjugating enzyme E2 [Trypanosoma cruzi strain CL Brener]
XP_807999.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_806523.1 IgE-dependent histamine-releasing factor [Trypanosoma cruzi strain CL Brener]
XP_808372.1 small nuclear ribonucleoprotein Sm-E [Trypanosoma cruzi strain CL Brener]
XP_818708.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
Strategy-1:-
XP_809166.1 mucin-associated surface protein (MASP) [Trypanosoma cruzi strain CL Brener]
XP_816522.1 mucin TcMUCII [Trypanosoma cruzi strain CL Brener]
XP_815016.1 90 kDa surface protein [Trypanosoma cruzi strain CL Brener]
XP_818708.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
XP_821916.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_804513.1 dispersed gene family protein 1 (DGF-1), partial [Trypanosoma cruzi strain CL Brener]
XP_816111.1 subtilisin-like serine peptidase [Trypanosoma cruzi strain CL Brener]
XP_806816.1 DnaJ chaperone protein [Trypanosoma cruzi strain CL Brener]
Strategy-2 vs Strategy-3
Strategy-2 vs Strategy-3
No intersection of proteins were found upon filtering of proteins via Strategy-2 and Strategy-3.
Union of proteins in Strategy-2 and Strategy-3:-
Union of proteins in Strategy-2 and Strategy-3:-
Strategy-2:-
XP_809166.1 mucin-associated surface protein (MASP) [Trypanosoma cruzi strain CL Brener]
XP_811700.1 mucin TcMUCII [Trypanosoma cruzi strain CL Brener]
XP_822020.1 90 kDa surface protein [Trypanosoma cruzi strain CL Brener]
XP_804447.1 ubiquitin-conjugating enzyme E2 [Trypanosoma cruzi strain CL Brener]
XP_807999.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_806523.1 IgE-dependent histamine-releasing factor [Trypanosoma cruzi strain CL Brener]
XP_808372.1 small nuclear ribonucleoprotein Sm-E [Trypanosoma cruzi strain CL Brener]
XP_818708.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
Strategy-3:-
XP_805056.1 mucin-associated surface protein (MASP) [Trypanosoma cruzi strain CL Brener]
XP_802955.1 mucin TcMUCII [Trypanosoma cruzi strain CL Brener]
XP_815016.1 90 kDa surface protein [Trypanosoma cruzi strain CL Brener]
XP_807308.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
XP_821176.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_804140.1 dispersed gene family protein 1 (DGF-1), partial [Trypanosoma cruzi strain CL Brener]
XP_816111.1 subtilisin-like serine peptidase [Trypanosoma cruzi strain CL Brener]
XP_806816.1 DnaJ chaperone protein [Trypanosoma cruzi strain CL Brener]
Strategy-2 vs Strategy-4
Strategy-2 vs Strategy-4
No intersection of proteins were found upon filtering of proteins via Strategy-2 and Strategy-4.
Union of proteins in Strategy-2 and Strategy-4:-
Union of proteins in Strategy-2 and Strategy-4:-
Strategy-2:-
XP_809166.1 mucin-associated surface protein (MASP) [Trypanosoma cruzi strain CL Brener]
XP_811700.1 mucin TcMUCII [Trypanosoma cruzi strain CL Brener]
XP_822020.1 90 kDa surface protein [Trypanosoma cruzi strain CL Brener]
XP_804447.1 ubiquitin-conjugating enzyme E2 [Trypanosoma cruzi strain CL Brener]
XP_807999.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_806523.1 IgE-dependent histamine-releasing factor [Trypanosoma cruzi strain CL Brener]
XP_808372.1 small nuclear ribonucleoprotein Sm-E [Trypanosoma cruzi strain CL Brener]
XP_818708.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
Strategy-4:-
XP_816052.1 phosphate-repressible phosphate permease [Trypanosoma cruzi strain CL Brener]
XP_807493.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_803296.1 dispersed gene family protein 1 (DGF-1), partial [Trypanosoma cruzi strain CL Brener]
XP_822017.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
XP_819804.1 nucleoside transporter-like [Trypanosoma cruzi strain CL Brener]
XP_820852.1 serine/threonine protein kinase [Trypanosoma cruzi strain CL Brener]
XP_815460.1 receptor-type adenylate cyclase, partial [Trypanosoma cruzi strain CL Brener]
XP_812509.1 UDP-N-acetylglucosamine--dolichyl-phosphate n- acetylglucosaminephosphotransferase [Trypanosoma cruzi CL Brener]
Strategy-2 vs Strategy-5
Strategy-2 vs Strategy-5
No intersection of proteins were found upon filtering of proteins via Strategy-2 and Strategy-5.
Union of proteins in Strategy-2 and Strategy-5:-
Union of proteins in Strategy-2 and Strategy-5:-
Strategy-2:-
XP_809166.1 mucin-associated surface protein (MASP) [Trypanosoma cruzi strain CL Brener]
XP_811700.1 mucin TcMUCII [Trypanosoma cruzi strain CL Brener]
XP_822020.1 90 kDa surface protein [Trypanosoma cruzi strain CL Brener]
XP_804447.1 ubiquitin-conjugating enzyme E2 [Trypanosoma cruzi strain CL Brener]
XP_807999.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_806523.1 IgE-dependent histamine-releasing factor [Trypanosoma cruzi strain CL Brener]
XP_808372.1 small nuclear ribonucleoprotein Sm-E [Trypanosoma cruzi strain CL Brener]
XP_818708.1 trans-sialidase [Trypanosoma cruzi strain CL Brener]
Strategy-5:-
XP_809117.1 hypothetical protein [Trypanosoma cruzi strain CL Brener]
XP_821990.1 mucin-associated surface protein (MASP [Trypanosoma cruzi strain CL Brener]
RNC42421.1 mucin TcMUCII [Trypanosoma cruzi]
XP_803883.1 GP85-like protein, partial [Trypanosoma cruzi strain CL Brener]
AAL90889.1 Tcc1j12.3 [Trypanosoma cruzi]
XP_809960.1 trans-sialidase [Trypanosoma cruzi strain CL brener]
XP_808931.1 mucin TcMUCIII {Trypanosoma cruzi strain CL Brener]
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