楊啓伸 老師

　　研究專長：結構生物學、生理學、生物物理學

A novel six-rhodopsin system in a single archaeon

　　After four years of intensive study, our lab unveiled a six-rhodopsin photosensory system, the most in microbes, in Haloarcula maris mortui. The system includes three ion translocating rhodopsins, two sensory rhodopsins and one sensory-like rhodopsin.

• HmBRI: Light-driven proton outward translocator; Bacteriorhodopsin-like.

• HmBRII: Light-driven proton outward translocator; Bacteriorhodopsin-like.

• HmHR: Light-driven chloride inward translocator; Halorhodopsin-like.

• HmSRI: Phototaxis sensory rhodopsin with a congnate transducer, HmHtrI.  Like those known as SRI.

• HmSRII: Photo-repellent sensory rhodopsin with a cognate transducer, HmHtrII. Like those known as SRII.

• HmSRM: Sensory-like rhodopsin working with a cognate transducer, HmHtrM. Instead of containing Histidine kinase binding domain found in any transducer associated with sensory rhodopsin, HmHtrM lacks such domain.

GPCR, RGS and G-protein signaling: basic scientific facts and biotechnological studies

　　Our lab is also working on G-protein related pathways in plant and higer systems. A GPCR drug screening system is under developments. 

Biomimicry based on Photoreceptors and their associated proteins

　　Bacteriorhodopsins are light-driven proton translocators. Biomimicry based on photoreceptors potentially can take advantage of sun light to drive the direct production of bioenergy or indirectly. Bacteriorhodopsin, Halorhodopsin, Sensory rhodopsins, transducers and F1/Fo ATPase are the candidates.