細胞動態實驗室致力於揭示生命中隱藏的律動，並解構其背後的調控原理。我們所研究的動態系統包括振盪器、多穩態開關以及觸發波。那些控制細胞生存、死亡與分化的動態系統特別引起我們的興趣。我們採用量化研究方法，整合生物、數學、工程和資料科學的理論和方法，來探究動態系統的生物功能。我們的最終目標是揭示細胞動態的普遍原則，並推動生物系統的設計與控制。

　The Lab for Cell Dynamics aims to uncover hidden biological rhythms and their regulatory principles. We study dynamic systems such as oscillators, toggle switches, and trigger waves, particularly those governing cell survival, death, and differentiation. Employing quantitative approaches, we integrate concepts from biology, mathematics, engineering, and informatics to explore the functions of these dynamics. Our ultimate goal is to reveal universal principles of biological dynamics for application in the design and control of living systems.

近年研究主題

大規模細胞死亡如何雕塑胚胎？

胚胎發育中的大規模細胞死亡：

　　我們發現，鐵死亡（ferroptosis）這種依賴鐵的細胞死亡形式，會在胚胎發育過程中以觸發波的方式傳播，引發大規模細胞死亡。我們專注於研究不同生物體如何利用大規模死亡來雕塑組織結構。

　Large-Scale Cell Death in Embryogenesis: During embryogenesis, we found that large-scale cell death can occur through propagation of ferroptosis, an iron-dependent form of cell death.  We study how ferroptosis propagation can be utilized as a tissue-sculpting strategy to eliminate temporary tissues in developing embryos.

如何控制像野火一樣傳播的細胞死亡？

活性氧多穩態和觸發波的形成：

　　在代謝壓力下，細胞內的活性氧（ROS: Reactive Oxygen Species）水平可表現出多穩態，並形成觸發波，導致大規模細胞死亡。我們致力於找出控制ROS多穩態和觸發波的調節因子，進而探索其在疾病治療上的潛力。

　Emergence of ROS Multistability and Trigger Waves: We explore how multistable redox states and ROS feedback loops lead to the emergence of trigger waves, causing widespread oxidative cell death. We are interested in identifying the molecular regulators underlying the emergence of ROS waves and we aim to modulate the wave for potential therapeutic strategies. 

每一顆細胞在想什麼？

單細胞動態研究：

　　我們透過單細胞縮時攝影和CRISPR基因標靶技術，偵測單細胞在決策過程中的訊號動態，並結合數學模型和時間序列分析，研究細胞動態如何決定細胞命運。

　Single-Cell Decision-Making Dynamics: We utilize time-lapse imaging and CRISPR-based gene targeting to observe and detect signaling dynamics in single cells. Integrating with mathematical modeling and time-series analysis, we study how signaling dynamics encode information for cell fate decisions.

設計控制細胞行為的生物電路

系統和合成生物：

　　我們透過了解訊號網路的系統，設計新穎的訊號分子和生物電路，以改變細胞狀態和決策過程。我們的目標是促進生理穩態，預防老化相關的細胞死亡，進而往疾病治療發展。

　Designing Synthetic Circuits for Cell Fate Control: We develop novel signaling molecules and bio-circuits to modulate cellular states and decisions. We aim to prevent cell death in aging-related conditions and eliminate cancer cells amidst genetic and non-genetic heterogeneities.