Publications

Research CV Publications

Selected papers

- Bertolotti M, Farinelli G, Galli M, Aiuti A, Sitia R (2016) AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells. J Leukoc Biol. 2016 Nov;100(5):1071-1079.

- Yang K, Li DF, Wang X, Liang J, Sitia R, Wang CC, Wang X (2016) Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention. Structure. 2016 Oct 4;24(10):1755-1765.

- Medraño-Fernandez I, Bestetti S, Bertolotti M, Bienert GP, Bottino C, Laforenza U, Rubartelli A, Sitia R. (2016) Stress Regulates Aquaporin-8 Permeability to Impact Cell Growth and Survival. Antioxid Redox Signal 2016 Jun 20;24(18):1031-44.

- Ronzoni R, Berardelli R, Medicina D, Sitia R, Gooptu B, Fra AM. (2016) Aberrant disulphide bonding contributes to the ER retention of alpha1-antitrypsin deficiency variants. Hum Mol Genet. 2016 Feb 15;25(4):642-50.

- Mossuto MF, Ami D, Anelli T, Fagioli C, Doglia SM, Sitia R. (2015) Biochemical nature of Russell Bodies. Sci Rep. 2015 Jul 30;5:12585. doi: 10.1038/srep12585.

- Sannino S, Anelli T, Cortini M, Masui S, Degano M, Fagioli C, Inaba K and Sitia R (2014) Progressive quality control in the early secretory compartment by ERp44. J Cell Sci, 2014 Aug 5 2014

- Vavassori S, Cortini M. Masui S, Sannino S. Anelli T. Caserta I, Fagioli C, Mossuto MF, Fornili A. van Anken Degano M, Inaba K and Sitia R (2013) A pH-regulated quality control cycle for surveillance of secretory protein assembly. Molecular Cell 50:783-92 See commentary in same issue

- Pengo N, Scolari M, Oliva L, Milan E, Mainoldi F, Raimondi A, Fagioli C, Merlini A, Mariani E, Pasqualetto E, Orfanelli U, Ponzoni M, Sitia R, Casola S, Cenci S (2013) Plasma cells require autophagy for sustainable immunoglobulin production. Nature Immunol. 14:298-305.

- Anelli T, Bergamelli L, Rimessi A, Fagioli C, Malgaroli A, Pinton P, Ripamonti M, Rizzuto R and Sitia R (2012) Ero1a regulates Ca²⁺ fluxes at the endoplasmic reticulum-mitochondria interface (MAM). Antioxid Redox Signal 16, 1007-87 (2012)

- Cortini M and Sitia R. (2010) ERp44 andERGIC-53 synergize in coupling efficiency and fidelity of IgM polymerization and secretion. Traffic, 11,651-659

- Bianchi G, Oliva L, Cascio P, Pengo N, Fontana F, Cerruti F, Orsi A, Pasqualetto E, Mezghrani A, Calbi V, Palladini G, Giuliani N, Anderson KC, Sitia R*, Cenci S*. (2009) The proteasome load vs.capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition. Blood. 113, 3040-9. * joint last authors

- Wang L, Wang L, Vavassori S, Li S, Ke H, Anelli T, Degano M, Ronzoni R, Sitia R*, Sun F* & Wang CC* (2008). Crystal structure of human ERp44 reveals a dynamic functional modulation by its C-terminal tail. EMBO Rep. 9, 642-7 *, joint last authors

- Anelli T, Ceppi S, Bergamelli L, Cortini M, Masciarelli S, Valetti C and Sitia R. (2007) Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis. EMBO J. 26, 4177-88

- Cenci S, Mezghrani A, Cascio P, Bianchi G, Cerruti F, Fra A, Lelouard H, Masciarelli S, Mattioli L, Oliva L, Orsi A, Pasqualetto E, Pierre P, Ruffato E, Tagliavacca L, and Sitia R. (2006) Progressively impaired proteasomal capacity during terminal plasma cell differentiation. EMBO J, 25, 1104-1113.

- Orsi A, Fioriti L, Chiesa R, Sitia R (2006) Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein. J Biol Chem 281, 30431-8

- Nerini-Molteni SN, Fassio A, Ciriolo MR, Filomeni G, Pasqualetto E, Fagioli C, Sitia R. (2004) Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum. J Biol Chem 279, 32667-73

- van Anken E, Romijn EP, Maggioni C, Mezghrani A, Sitia R*, Braakman I*, and Heck AJR* (2003) Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion. Immunity 18, 243-53. * joint last authors

- Anelli T, Alessio M, Mezghrani A, Simmen T, Talamo F, Bachi A, Sitia R. (2002) ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family. EMBO J. 21, 835

- Mezghrani A., Fassio A., Benham A., Simmen T., Braakman I., Sitia R. (2001). Manipulation of Oxidative Protein Folding and PDI Redox State in Mammalian Cells. EMBO J. 20, 6288.

- Reddy P., Sparvoli A., Fagioli C., Fassina G. and Sitia R. (1996). Formation of reversible disulfide bonds with the protein matrix of the endoplasmic reticulum correlates with the retention of unassembled Ig-light chains. EMBO J. 15, 2077-2085

- Rubartelli A., Bajetto A., Allavena G., Wollman E. and Sitia R. (1992). Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway. J. Biol. Chem. 267, 24161-24164.

- Valetti C., Grossi C.E., Milstein C. and Sitia R. (1991). Russell bodies: a general response of secretory cells to synthesis of a mutant immunoglobulin which can neither exit from, nor be degraded in, the endoplasmic reticulum. J. Cell Biol. 115, 983-994.

- Sitia R, Neuberger MS, Alberini C, Bet P, Fra AM, Valetti C, Williams G and Milstein C. (1990). Developmental regulation of IgM secretion: the role of the carboxy-terminal cysteine. Cell 60, 781-790.

- Alberini CM, Bet P, Milstein C, Sitia R. (1990) Secretion of immunoglobulin M assembly intermediates in the presence of reducing agents. Nature. 347:485-7.

- Klausner R.D., and Sitia R. (1990). Protein degradation in the endoplasmic reticulum. Cell 62, 611-614

- Stavnezer J, Radcliffe G, Lin YC, Nietupski J, Berggren L, Sitia R, and Severinson E. (1988). Ig heavy chain switching may be directed by prior induction of transcripts from constant region genes. Proc. Natl. Acad. Sci. USA. 85, 7704-7708.

- Sitia R, Neuberger MS, and Milstein C. (1987). Regulation of membrane IgM expression in secretory B cells: translational and posttranslational events. EMBO J. 6, 3969-3977

- Sitia R, Corte G, Ferrarini M, and Bargellesi A. (1977). Lymphocyte membrane immunoglobulins: similarities between human IgD and mouse IgD-like molecules. Eur.J. Immunol. 7, 503-507

Monographs and review articles

- Anelli T, Sannino S, Sitia R. (2015) Proteostasis and "redoxtasis" in the secretory pathway: Tales of tails from ERp44 and immunoglobulins. Free Radic Biol Med. 2015 Jun;83:323-30.

- Bertolotti M, Sitia R, Rubartelli A. (2012) On the redox control of B lymphocyte differentiation and function. Antioxid Redox Signal. 2012 May 15;16(10):1139-49.

- Kakihana T, Nagata K, Sitia R (2012) Peroxides and peroxidases in the endoplasmic reticulum: integrating redox homeostasis and oxidative folding. Antioxid Redox Signal 15:763-71

- Cenci S, Van Anken E and Sitia R (2011) Proteostenosis and plasma cell pathophysiology. Curr. Opin. Cell Biol. 23, 216-222

- Anelli T and Sitia R (2010) Physiology and pathology of proteostasis in the early secretory compartment. Semin Cell Dev Biol. 21:520-5. .

- Rubartelli A and Sitia R (2009) Stress as an intercellular signal: the emergence os stress associated molecular patterns (SAMP) Antioxid Redox Signal 11:2621-9.

- Anelli T and Sitia R (2008) Protein quality control in the early secretory pathway EMBO J. 27,315-27.

- Cenci S and Sitia R (2007) Managing andexploiting stress in the antibody factory. FEBS Lett. 581,3652-7.

- Sitia R, Nerini-Molteni SN. (2004) Stress, protein (mis)folding, and signaling: the redox connection. Science STKE. 239, 27

- Sitia R and Braakman I. (2003). Quality control in the endoplasmic reticulum protein factory. Nature 426, 891-4. .